Introduction to Psychoneuroimmunology

Introduction to Psychoneuroimmunology

2nd Edition - February 24, 2012

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  • Author: Jorge Daruna
  • Hardcover ISBN: 9780123820495
  • eBook ISBN: 9780123820808

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Health is maintained by the coordinated operation of all the biological systems that make up the individual. The Introduction to Psychoneuroimmunology, Second Edition, presents an overview of what has been discovered by scientists regarding how bodily systems respond to environmental challenges and intercommunicate to sustain health. The book touches on the main findings from the current literature without being overly technical and complex. The result is a comprehensive overview of psychoneuroimmunology, which avoids oversimplification, but does not overwhelm the reader.

Key Features

  • Single authored for consistency of breadth and depth, with no redundancy of coverage between chapters
  • Covers endocrine-immune modulation, neuro-immune modulation, and the enhancing or inhibiting processes of one or more systems on the others
  • Expanded use of figures, tables, and text boxes


Psychologists, neuroscientists, endocrinologists, immunologists, psychiatrists, physicians and pre- and postdoctoral students in psychology, the neurosciences, microbiology and immunology, endocrinology, physiology, and pharmacology

Table of Contents

  • Dedication



    Chapter 1. Introduction

    I Aim and Organization

    II Historical Roots

    III Immune System

    IV Life-Sustaining Systems Intercommunicate

    V Stress and its Impact on the Body

    VI Psychosocial Stress and Disease

    VII Sustaining Health

    VIII Implications for Research and Healthcare

    IX. Source

    Chapter 2. Historical Antecedents

    I Introduction

    II Health

    III Social Organization, Health, and Healing

    IV Early Ideas about Health and Disease

    V Empirical Approaches to Health

    VI Science and Health

    VII Concluding Comments

    VIII. Sources

    Chapter 3. Immune System Basics

    I Introduction

    II Molecular Self/Non-Self Discrimination

    III Cell Types, Proteins, and Genes

    IV Complement System

    V Immune Cell Types and Functions

    VI Inflammation

    VII Human Leukocyte Antigen System

    VIII Antigen Presentation

    IX Natural Killer Cells

    X B Lymphocytes, Antibody Structure, and Diversity

    XI T Lymphocytes

    XII Cytokines, Chemokines, and Cell Adhesion Molecules

    XIII Lymphoid Organs and Leukocyte Traffic

    XIV Immune Activation/Deactivation and Memory

    XV Development of Immune Functions

    XVI Measures of Immune Function

    XVII Concluding Comments

    XVIII. Sources

    Chapter 4. Endocrine-Immune Modulation

    I Introduction

    II Endocrine System

    III Cytokines, Hormones, and their Receptors

    IV Anterior Pituitary Hormones and Immune Function

    V Posterior Pituitary Hormones and Immune Function

    VI Other Hormones and Immune Function

    VII Thymus–Pituitary Axis and Immune Function

    VIII Other Organs/Tissues and Immune Function

    IX Endocrine Signaling and Energy Allocation

    X Concluding Comments

    XI. Sources

    Chapter 5. Neuroimmune Modulation

    I Introduction

    II Peripheral Nervous System

    III Peripheral Nervous System Innervation of Lymphoid Organs

    IV Chemical Signaling in the Periphery

    V Functional Effects of Peripheral Neuroimmune Interactions

    VI Central Nervous System

    VII Bidirectional Central Nervous System–Immune System Interactions

    VIII Learning and Immune Responses

    IX Personality and Immune Function

    X Concluding Comments

    XI. Sources

    Chapter 6. Stress, Contextual Change, and Disease

    I Introduction

    II Selye’s Concept of Stress

    III Critiques and Debates

    IV Ranking Life Events as Stressful

    V Stress as Contextual Change

    VI Disease as Contextual Change

    VII Health State Space

    VIII Concluding Comments

    IX. Sources

    Chapter 7. Psychosocial Stress

    I Introduction

    II Psychosocial Stress

    III Effects on Endocrine Activity

    IV Effects on Autonomic and Peripheral Neural Activity

    V Effects on the Central Nervous System

    VI Effects on the Immune System

    VII Early Life Adversity and Later Trauma

    VIII Neuroendocrine–Immune Pathways

    IX Concluding Comments

    X. Sources

    Chapter 8. Infection, Allergy, and Psychosocial Stress

    I Introduction

    II Infectious Diseases

    III Allergic Diseases

    IV Concluding Comments

    V. Sources

    Chapter 9. Cancer, Autoimmunity, and Psychosocial Stress

    I Introduction

    II Cancer

    III Autoimmune Diseases

    IV Concluding Comments

    V. Sources

    Chapter 10. Immune Activity and Psychopathology

    I Introduction

    II Access to Brain by Pathogens

    III Immune Activity within the Brain

    IV Sensing Peripheral Immune Activity

    V Sickness Behavior

    VI Behavioral Disorders that Resemble Sickness Behavior

    VII Nervous System Infections and Behavior

    VIII Autoimmunity, Malignancy, and Behavior

    IX Psychiatric Disorders Alter Immune Activity

    X Psychiatric Disorders with a Link to Infection

    XI Concluding Comments

    XII. Sources

    Chapter 11. Immune Function Enhancement

    I Introduction

    II Cognitive Processes: Beliefs and Expectations

    III Expression of Emotion

    IV Humor and Laughter

    V Social Interaction and Physical Contact

    VI Sleep, Relaxation, and Meditative States

    VII Exercise and Physical Activity

    VIII Diet

    IX Concluding Comments

    X. Sources

    Chapter 12. Integration and Implications

    I Introduction

    II Synopsis

    III Microenvironments and Complexity

    IV Unnecessary and Insufficient

    V Implications for Research

    VI Implications for Healthcare

    VII Economic Considerations

    VIII Concluding Comments

    IX. Sources




Product details

  • No. of pages: 336
  • Language: English
  • Copyright: © Academic Press 2012
  • Published: February 24, 2012
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123820495
  • eBook ISBN: 9780123820808

About the Author

Jorge Daruna

Affiliations and Expertise

Ochsner Clinic Foundation, New Orleans, Louisiana, U.S.A.

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