Introduction to Biomedical Engineering

Introduction to Biomedical Engineering

3rd Edition - March 7, 2011

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  • Authors: John Enderle, Joseph Bronzino
  • eBook ISBN: 9780080961217
  • Hardcover ISBN: 9780123749796

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Introduction to Biomedical Engineering is a comprehensive survey text for biomedical engineering courses. It is the most widely adopted text across the BME course spectrum, valued by instructors and students alike for its authority, clarity and encyclopedic coverage in a single volume. Biomedical engineers need to understand the wide range of topics that are covered in this text, including basic mathematical modeling; anatomy and physiology; electrical engineering, signal processing and instrumentation; biomechanics; biomaterials science and tissue engineering; and medical and engineering ethics. Enderle and Bronzino tackle these core topics at a level appropriate for senior undergraduate students and graduate students who are majoring in BME, or studying it as a combined course with a related engineering, biology or life science, or medical/pre-medical course. NEW: Each chapter in the 3rd Edition is revised and updated, with new chapters and materials on compartmental analysis, biochemical engineering, transport phenomena, physiological modeling and tissue engineering. Chapters on peripheral topics have been removed and made avaialblw online, including optics and computational cell biology NEW: many new worked examples within chapters NEW: more end of chapter exercises, homework problems NEW: image files from the text available in PowerPoint format for adopting instructors Readers benefit from the experience and expertise of two of the most internationally renowned BME educators Instructors benefit from a comprehensive teaching package including a fully worked solutions manual

Key Features

  • A complete introduction and survey of BME
  • NEW: new chapters on compartmental analysis, biochemical engineering, and biomedical transport phenomena
  • NEW: revised and updated chapters throughout the book feature current research and developments in, for example biomaterials, tissue engineering, biosensors, physiological modeling, and biosignal processing
  • NEW: more worked examples and end of chapter exercises
  • NEW: image files from the text available in PowerPoint format for adopting instructors
  • As with prior editions, this third edition provides a historical look at the major developments across biomedical domains and covers the fundamental principles underlying biomedical engineering analysis, modeling, and design
  • Bonus chapters on the web include: Rehabilitation Engineering and Assistive Technology, Genomics and Bioinformatics, and Computational Cell Biology and Complexity


Senior undergraduate and graduate level students of biomedical engineering and related courses in biological & life sciences and chemical, mechanical and electrical engineering

Table of Contents

  • Dedication


    Contributors to the Third Edition

    Contributors to the Second Edition

    Contributors to the First Edition

    Chapter 1. Biomedical Engineering

    1.1. The Evolution of the Modern Health Care System

    1.2. The Modern Health Care System

    1.3. What Is Biomedical Engineering?

    1.4. Roles Played by the Biomedical Engineers

    1.5. Recent Advances in Biomedical Engineering

    1.6. Professional Status of Biomedical Engineering

    1.7. Professional Societies

    Chapter 2. Moral and Ethical Issues

    2.1. Morality and Ethics: A Definition of Terms

    2.2. Two Moral Norms: Beneficence and Nonmaleficence

    2.3. Redefining Death

    2.4. The Terminally Ill Patient and Euthanasia

    2.5. Taking Control

    2.6. Human Experimentation

    2.7. Definition and Purpose of Experimentation

    2.8. Informed Consent

    2.9. Regulation of Medical Device Innovation

    2.10. Marketing Medical Devices

    2.11. Ethical Issues in Feasibility Studies

    2.12. Ethical Issues in Emergency Use

    2.13. Ethical Issues in Treatment Use

    2.14. The Role of the Biomedical Engineer in the FDA Process

    Chapter 3. Anatomy and Physiology

    3.1. Introduction

    3.2. Cellular Organization

    3.3. Tissues

    3.4. Major Organ Systems

    3.5. Homeostasis

    Chapter 4. Biomechanics

    4.1. Introduction

    4.2. Basic Mechanics

    4.3. Mechanics of Materials

    4.4. Viscoelastic Properties

    4.5. Cartilage, Ligament, Tendon, and Muscle

    4.6. Clinical Gait Analysis

    4.7. Cardiovascular Dynamics

    Chapter 5. Biomaterials

    5.1. Materials in Medicine: From Prosthetics to Regeneration

    5.2. Biomaterials: Types, Properties, and Their Applications

    5.3. Lessons from Nature on Biomaterial Design and Selection

    5.4. Tissue–Biomaterial Interactions

    5.5. Biomaterials Processing Techniques for Guiding Tissue Repair and Regeneration

    5.6. Safety Testing and Regulation of Biomaterials

    5.7. Application-Specific Strategies for the Design and Selection of Biomaterials

    Chapter 6. Tissue Engineering

    6.1. What Is Tissue Engineering?

    6.2. Biological considerations

    6.3. Physical considerations

    6.4. Scaling up

    6.5. Implementation of Tissue Engineered Products

    6.6. Future Directions: Functional Tissue Engineering and the “-Omics” Sciences

    6.7. Conclusions

    Chapter 7. Compartmental Modeling

    7.1. Introduction

    7.2. Solutes, Compartments, and Volumes

    7.3. Transfer of Substances between Two Compartments Separated by a Membrane

    7.4. Compartmental Modeling Basics

    7.5. One-Compartment Modeling

    7.6. Two-Compartment Modeling

    7.7. Three-Compartment Modeling

    7.8. Multicompartment Modeling

    Chapter 8. Biochemical Reactions and Enzyme Kinetics

    8.1. Chemical Reactions

    8.2. Enzyme Kinetics

    8.3. Additional Models Using the Quasi-Steady-State Approximation

    8.4. Diffusion, Biochemical Reactions, and Enzyme Kinetics

    8.5. Cellular Respiration: Glucose Metabolism and the Creation of ATP

    8.6. Enzyme Inhibition, Allosteric Modifiers, and Cooperative Reactions

    Chapter 9. Bioinstrumentation

    9.1. Introduction

    9.2. Basic Bioinstrumentation System

    9.3. Charge, Current, Voltage, Power, and Energy

    9.4. Resistance

    9.5. Linear Network Analysis

    9.6. Linearity and Superposition

    9.7. Thévenin's Theorem

    9.8. Inductors

    9.9. Capacitors

    9.10. A General Approach to Solving Circuits Involving Resistors, Capacitors, and Inductors

    9.11. Operational Amplifiers

    9.12. Time-Varying Signals

    9.13. Active Analog Filters

    9.14. Bioinstrumentation Design

    Chapter 10. Biomedical Sensors

    10.1. Introduction

    10.2. Biopotential Measurements

    10.3. Physical Measurements

    10.4. Blood Gas Sensors

    10.5. Bioanalytical Sensors

    10.6. Optical Sensors

    Chapter 11. Biosignal Processing

    11.1. Introduction

    11.2. Physiological Origins of Biosignals

    11.3. Characteristics of Biosignals

    11.4. Signal Acquisition

    11.5. Frequency Domain Representation of Biological Signals

    11.6. Linear Systems

    11.7. Signal Averaging

    11.8. The Wavelet Transform and the Short-Time Fourier Transform

    11.9. Artificial Intelligence Techniques

    Chapter 12. Bioelectric Phenomena

    12.1. Introduction

    12.2. History

    12.3. Neurons

    12.4. Basic Biophysics Tools and Relationships

    12.5. Equivalent Circuit Model for the Cell Membrane

    12.6. The Hodgkin-Huxley Model of the Action Potential

    12.7. Model of a Whole Neuron

    12.8. Chemical Synapses

    Chapter 13. Physiological Modeling

    13.1. Introduction

    13.2. An Overview of the Fast Eye Movement System

    13.3. The Westheimer Saccadic Eye Movement Model

    13.4. The Saccade Controller

    13.5. Development of an Oculomotor Muscle Model

    13.6. The 1984 Linear Reciprocal Innervation Saccadic Eye Movement Model

    13.7. The 1995 Linear Homeomorphic Saccadic Eye Movement Model

    13.8. The 2009 Linear Homeomorphic Saccadic Eye Movement Model

    13.9. Saccade Neural Pathways

    13.10. System Identification

    Chapter 14. Biomedical Transport Processes

    14.1. Biomedical Mass Transport

    14.2. Biofluid Mechanics and Momentum Transport

    14.3. Biomedical Heat Transport

    Chapter 15. Radiation Imaging

    15.1. Introduction

    15.2. Emission Imaging Systems

    15.3. Instrumentation and Imaging Devices

    15.4. Radiographic Imaging Systems

    Chapter 16. Medical Imaging

    16.1. Introduction

    16.2. Diagnostic ultrasound imaging

    16.3. Magnetic resonance imaging

    16.4. Magnetoencephalography

    16.5. Contrast agents

    16.6. Comparison of imaging modes

    16.7. Image Fusion

    16.8. Summary

    Chapter 17. Biomedical Optics and Lasers

    17.1. Introduction to Essential Optical Principles

    17.2. Fundamentals of Light Propagation in Biological Tissue

    17.3. Physical Interaction of Light and Physical Sensing

    17.4. Biochemical Measurement Techniques Using Light

    17.5. Fundamentals of the Photothermal Therapeutic Effects of Light Sources

    17.6. Fiber Optics and Waveguides in Medicine

    17.7. Biomedical Optical Imaging



Product details

  • No. of pages: 1272
  • Language: English
  • Copyright: © Academic Press 2011
  • Published: March 7, 2011
  • Imprint: Academic Press
  • eBook ISBN: 9780080961217
  • Hardcover ISBN: 9780123749796

About the Authors

John Enderle

John Enderle is among the best known biomedical engineers in the world. He is Editor-in-Chief of the IEEE EMB Magazine (Engineering in Medicine and Biology Society, the key electrical systems-oriented BME society). An electrical engineer by training, he is a Fellow of the Institute of Electrical and Electronics Engineers (IEEE), a past-president of the IEEE Engineering in Medicine and Biology Society, and a Fellow of the American Institute for Medical and Biological Engineering (AIMBE). He is also an ABET program evaluator for bioengineering programs and a member of the American Society for Engineering Education.

Affiliations and Expertise

School of Engineering, University of Connecticut, Storrs, CT, USA

Joseph Bronzino

Joseph Bronzino is one of the most renowned biomedical engineers in the world. He is a former president of the IEEE Engineering in Medicine and Biology, and well-known educator. He is editor-in-chief of the Biomedical Engineering Handbook from CRC Press, and is currently editor of the Academic Press Series in Biomedical Engineering. He is the Vernon Roosa Professor of Applied Science at Trinity College in Hartford, Connecticut.

Affiliations and Expertise

Trinity College, Hartford, CT, USA

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