Introduction to Biomedical Engineering - 2nd Edition - ISBN: 9780122386626, 9780080473147

Introduction to Biomedical Engineering

2nd Edition

Authors: John Enderle Joseph Bronzino Susan Blanchard
eBook ISBN: 9780080473147
Hardcover ISBN: 9780122386626
Imprint: Academic Press
Published Date: 6th April 2005
Page Count: 1144
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Table of Contents

Dedication

PREFACE

ACKNOWLEDGEMENTS

CONTRIBUTORS TO THE FIRST EDITION

CONTRIBUTORS TO THE SECOND EDITION

1. BIOMEDICAL ENGINEERING: A HISTORICAL PERSPECTIVE

1.1 EVOLUTION OF THE MODERN HEALTH CARE SYSTEM

1.2 THE MODERN HEALTH CARE SYSTEM

1.3 WHAT IS BIOMEDICAL ENGINEERING

1.4 ROLES PLAYED BY BIOMEDICAL ENGINEERS

1.5 PROFESSIONAL STATUS OF BIOMEDICAL ENGINEERING

1.6 PROFESSIONAL SOCIETIES

EXERCISES

REFERENCES AND SUGGESTED READING

2. MORAL AND ETHICAL ISSUES

2.1 MORALITY AND ETHICS: A DEFINITION OF TERMS

2.2 TWO MORAL NORMS: BENEFICENCE AND NONMALEFICENCE

2.3 REDEFINING DEATH

2.4 THE TERMINALLY ILL PATIENT AND EUTHANASIA

2.5 TAKING CONTROL

2.6 HUMAN EXPERIMENTATION

2.7 DEFINITION AND PURPOSE OF EXPERIMENTATION

2.8 INFORMED CONSENT

2.9 REGULATION OF MEDICAL DEVICE INNOVATION

2.10 MARKETING MEDICAL DEVICES

2.11 ETHICAL ISSUES IN FEASIBILITY STUDIES

2.12 ETHICAL ISSUES IN EMERGENCY USE

2.13 ETHICAL ISSUES IN TREATMENT USE

2.14 THE ROLE OF THE BIOMEDICAL ENGINEER IN THE FDA PROCESS

EXERCISES

SUGGESTED READING

3. ANATOMY AND PHYSIOLOGY

3.1 INTRODUCTION

3.2 CELLULAR ORGANIZATION

3.3 Tissues

3.4 MAJOR ORGAN SYSTEMS

3.5 HOMEOSTASIS

EXERCISES

SUGGESTED READING

4. BIOMECHANICS

4.1 INTRODUCTION

4.2 BASIC MECHANICS

4.3 MECHANICS OF MATERIALS

4.4 VISCOELASTIC PROPERTIES

4.5 CARTILAGE, LIGAMENT, TENDON, AND MUSCLE

4.6 CLINICAL GAIT ANALYSIS

4.7 CARDIOVASCULAR DYNAMICS

Exercises

SUGGESTED READING

5. REHABILITATION ENGINEERING AND ASSISTIVE TECHNOLOGY

5.1 INTRODUCTION

5.2 THE HUMAN COMPONENT

5.3 PRINCIPLES OF ASSISTIVE TECHNOLOGY ASSESSMENT

5.4 PRINCIPLES OF REHABILITATION ENGINEERING

5.5 PRACTICE OF REHABILITATION ENGINEERING AND ASSISTIVE TECHNOLOGY

EXERCISES

SUGGESTED READING

6. BIOMATERIALS

6.1 MATERIALS IN MEDICINE: FROM PROSTHETICS TO REGENERATION

6.2 BIOMATERIALS: PROPERTIES, TYPES, AND APPLICATIONS

6.3 LESSONS FROM NATURE ON BIOMATERIAL DESIGN AND SELECTION

6.4 TISSUE–BIOMATERIAL INTERACTIONS

6.5 GUIDING TISSUE REPAIR WITH BIO-INSPIRED BIOMATERIALS

6.6 SAFETY TESTING AND REGULATION OF BIOMATERIALS

6.7 APPLICATION-SPECIFIC STRATEGIES FOR THE DESIGN AND SELECTION OF BIOMATERIALS

EXERCISES

SUGGESTED READING

7. TISSUE ENGINEERING

7.1 WHAT IS TISSUE ENGINEERING?

7.2 BIOLOGICAL CONSIDERATIONS

7.3 PHYSICAL CONSIDERATIONS

7.4 SCALING UP

7.5 IMPLEMENTATION OF TISSUE ENGINEERED PRODUCTS

7.6 FUTURE DIRECTIONS: FUNCTIONAL TISSUE ENGINEERING AND THE “-OMICS” SCIENCES

7.7 CONCLUSIONS

7.8 Glossary

EXERCISES

SUGGESTED READING

8. BIOINSTRUMENTATION

8.1 INTRODUCTION

8.2 BASIC BIOINSTRUMENTATION SYSTEM

8.3 CHARGE, CURRENT, VOLTAGE, POWER, AND ENERGY

8.4 RESISTANCE

8.5 LINEAR NETWORK ANALYSIS

8.6 LINEARITY AND SUPERPOSITION

8.7 THÉVENIN’S THEOREM

8.8 INDUCTORS

8.9 CAPACITORS

8.10 A GENERAL APPROACH TO SOLVING CIRCUITS INVOLVING RESISTORS, CAPACITORS, AND INDUCTORS

8.11 OPERATIONAL AMPLIFIERS

8.12 TIME-VARYING SIGNALS

8.13 ACTIVE ANALOG FILTERS

8.14 BIOINSTRUMENTATION DESIGN

Exercises

SUGGESTED READING

9. BIOMEDICAL SENSORS

9.1 INTRODUCTION

9.2 BIOPOTENTIAL MEASUREMENTS

9.3 PHYSICAL MEASUREMENTS

9.4 BLOOD GASES AND PH SENSORS

9.5 BIOANALYTICAL SENSORS

9.6 OPTICAL BIOSENSORS

EXERCISES

SUGGESTED READING

10. BIOSIGNAL PROCESSING

10.1 INTRODUCTION

10.2 PHYSIOLOGICAL ORIGINS OF BIOSIGNALS

10.3 CHARACTERISTICS OF BIOSIGNALS

10.4 SIGNAL ACQUISITION

10.5 FREQUENCY DOMAIN REPRESENTATION OF BIOLOGICAL SIGNALS

10.5.5 Properties of the Fourier Transform

10.6 LINEAR SYSTEMS

10.7 SIGNAL AVERAGING

10.8 WAVELET TRANSFORM AND SHORT-TIME FOURIER TRANSFORM

10.9 ARTIFICIAL INTELLIGENCE TECHNIQUES

EXERCISES

SUGGESTED READING

11. BIOELECTRIC PHENOMENA

11.1 INTRODUCTION

11.2 HISTORY

11.3 NEURONS

11.4 BASIC BIOPHYSICS TOOLS AND RELATIONSHIPS

11.5 EQUIVALENT CIRCUIT MODEL FOR THE CELL MEMBRANE

11.6 HODGKIN–HUXLEY MODEL OF THE ACTION POTENTIAL

11.7 MODEL OF THE WHOLE NEURON

EXERCISES

SUGGESTED READING

12. PHYSIOLOGICAL MODELING

12.1 INTRODUCTION

12.2 COMPARTMENTAL MODELING

12.3 AN OVERVIEW OF THE FAST EYE MOVEMENT SYSTEM

12.4 WESTHEIMER SACCADIC EYE MOVEMENT MODEL

12.5 THE SACCADE CONTROLLER

12.6 DEVELOPMENT OF AN OCULOMOTOR MUSCLE MODEL

12.7 A LINEAR MUSCLE MODEL

12.8 A LINEAR HOMEOMORPHIC SACCADIC EYE MOVEMENT MODEL

12.9 A TRUER LINEAR HOMEOMORPHIC SACCADIC EYE MOVEMENT MODEL

12.10 SYSTEM IDENTIFICATION

EXERCISES

SUGGESTED READING

13. GENOMICS AND BIOINFORMATICS

13.1 INTRODUCTION

13.2 CORE LABORATORY TECHNOLOGIES

13.3 CORE BIOINFORMATICS TECHNOLOGIES

13.4 CONCLUSION

EXERCISES

SUGGESTED READING

14. COMPUTATIONAL CELL BIOLOGY AND COMPLEXITY

14.1 COMPUTATIONAL BIOLOGY

14.2 THE MODELING PROCESS

14.3 BIONETWORKS

14.4 INTRODUCTION TO COMPLEXITY THEORY

EXERCISES

SUGGESTED READING

15. RADIATION IMAGING

15.1 INTRODUCTION

15.2 EMISSION IMAGING SYSTEMS

15.3 INSTRUMENTATION AND IMAGING DEVICES

15.4 RADIOGRAPHIC IMAGING SYSTEMS

EXERCISES

SUGGESTED READING

16. MEDICAL IMAGING

16.1 INTRODUCTION

16.2 DIAGNOSTIC ULTRASOUND IMAGING

16.3 MAGNETIC RESONANCE IMAGING (MRI)

16.4 COMPARISON OF IMAGING MODES

EXERCISES

SUGGESTED READING

17. BIOMEDICAL OPTICS AND LASERS

17.1 INTRODUCTION TO ESSENTIAL OPTICAL PRINCIPLES

17.2 FUNDAMENTALS OF LIGHT PROPAGATION IN BIOLOGICAL TISSUE

17.3 Physical Interaction of Light and Physical Sensing

17.4 BIOCHEMICAL MEASUREMENT TECHNIQUES USING LIGHT

17.5 Fundamentals of Photothermal Therapeutic Effects of Lasers

17.6 FIBER OPTICS AND WAVEGUIDES IN MEDICINE

17.7 BIOMEDICAL OPTICAL IMAGING

EXERCISES

SUGGESTED READING

APPENDIX

A.1 MATLAB

A.2 Solving Differential Equations Using MATLAB

A.3 BLOCK DIAGRAMS AND SIMULINK

A.4 SIMULINK

INDEX


Description

Under the direction of John Enderle, Susan Blanchard and Joe Bronzino, leaders in the field have contributed chapters on the most relevant subjects for biomedical engineering students. These chapters coincide with courses offered in all biomedical engineering programs so that it can be used at different levels for a variety of courses of this evolving field.

Introduction to Biomedical Engineering, Second Edition provides a historical perspective of the major developments in the biomedical field. Also contained within are the fundamental principles underlying biomedical engineering design, analysis, and modeling procedures. The numerous examples, drill problems and exercises are used to reinforce concepts and develop problem-solving skills making this book an invaluable tool for all biomedical students and engineers.

New to this edition: Computational Biology, Medical Imaging, Genomics and Bioinformatics.

Key Features

  • 60% update from first edition to reflect the developing field of biomedical engineering
  • New chapters on Computational Biology, Medical Imaging, Genomics, and Bioinformatics
  • Companion site: http://intro-bme-book.bme.uconn.edu/
  • MATLAB and SIMULINK software used throughout to model and simulate dynamic systems
  • Numerous self-study homework problems and thorough cross-referencing for easy use

Readership

Biomedical Engineering Students; as a reference for bioengineers


Details

No. of pages:
1144
Language:
English
Copyright:
© Academic Press 2005
Published:
Imprint:
Academic Press
eBook ISBN:
9780080473147
Hardcover ISBN:
9780122386626

Reviews

"...this is certainly the most comprehensive textbook of its kind, and is recommended not only for undergraduate BME students but also for BME engineers in the industry or at the graduate level in academia, as a reference book for a quick dive into new topics, or for an up-to-date survey of recent developments in this field." Amit Gefen, BioMedical Engineering "Provides the most thorough review of concepts from biomaterials and tissue engineering to bioinstrumentation and medical imaging." Armando Perraioli, Italy, in the IEEE Engineering in Medicine and Biology Magazine


About the Authors

John Enderle Author

John Enderle is among the best known biomedical engineers in the world. He is Editor-in-Chief of the IEEE EMB Magazine (Engineering in Medicine and Biology Society, the key electrical systems-oriented BME society). An electrical engineer by training, he is a Fellow of the Institute of Electrical and Electronics Engineers (IEEE), a past-president of the IEEE Engineering in Medicine and Biology Society, and a Fellow of the American Institute for Medical and Biological Engineering (AIMBE). He is also an ABET program evaluator for bioengineering programs and a member of the American Society for Engineering Education.

Affiliations and Expertise

School of Engineering, University of Connecticut, Storrs, CT, USA

Joseph Bronzino Author

Joseph Bronzino is one of the most renowned biomedical engineers in the world. He is a former president of the IEEE Engineering in Medicine and Biology, and well-known educator. He is editor-in-chief of the Biomedical Engineering Handbook from CRC Press, and is currently editor of the Academic Press Series in Biomedical Engineering. He is the Vernon Roosa Professor of Applied Science at Trinity College in Hartford, Connecticut.

Affiliations and Expertise

Trinity College, Hartford, CT, USA

Susan Blanchard Author

Susan Blanchard is among the best known biomedical engineers in the world. She is the outgoing president of the IEEE Engineering in Medicine and Biology society.

Affiliations and Expertise

Founding Director, School of Engineering Florida Gulf Coast University Fort Myers, FL