Introduction to Biomedical Engineering

Introduction to Biomedical Engineering

2nd Edition - April 6, 2005

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  • Authors: John Enderle, Joseph Bronzino, Susan Blanchard
  • eBook ISBN: 9780080473147

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Description

Under the direction of John Enderle, Susan Blanchard and Joe Bronzino, leaders in the field have contributed chapters on the most relevant subjects for biomedical engineering students. These chapters coincide with courses offered in all biomedical engineering programs so that it can be used at different levels for a variety of courses of this evolving field. Introduction to Biomedical Engineering, Second Edition provides a historical perspective of the major developments in the biomedical field. Also contained within are the fundamental principles underlying biomedical engineering design, analysis, and modeling procedures. The numerous examples, drill problems and exercises are used to reinforce concepts and develop problem-solving skills making this book an invaluable tool for all biomedical students and engineers. New to this edition: Computational Biology, Medical Imaging, Genomics and Bioinformatics.

Key Features

* 60% update from first edition to reflect the developing field of biomedical engineering
* New chapters on Computational Biology, Medical Imaging, Genomics, and Bioinformatics
* Companion site: http://intro-bme-book.bme.uconn.edu/
* MATLAB and SIMULINK software used throughout to model and simulate dynamic systems
* Numerous self-study homework problems and thorough cross-referencing for easy use

Readership

Biomedical Engineering Students; as a reference for bioengineers

Table of Contents

  • Dedication

    PREFACE

    ACKNOWLEDGEMENTS

    CONTRIBUTORS TO THE FIRST EDITION

    CONTRIBUTORS TO THE SECOND EDITION

    1. BIOMEDICAL ENGINEERING: A HISTORICAL PERSPECTIVE

    1.1 EVOLUTION OF THE MODERN HEALTH CARE SYSTEM

    1.2 THE MODERN HEALTH CARE SYSTEM

    1.3 WHAT IS BIOMEDICAL ENGINEERING

    1.4 ROLES PLAYED BY BIOMEDICAL ENGINEERS

    1.5 PROFESSIONAL STATUS OF BIOMEDICAL ENGINEERING

    1.6 PROFESSIONAL SOCIETIES

    EXERCISES

    REFERENCES AND SUGGESTED READING

    2. MORAL AND ETHICAL ISSUES

    2.1 MORALITY AND ETHICS: A DEFINITION OF TERMS

    2.2 TWO MORAL NORMS: BENEFICENCE AND NONMALEFICENCE

    2.3 REDEFINING DEATH

    2.4 THE TERMINALLY ILL PATIENT AND EUTHANASIA

    2.5 TAKING CONTROL

    2.6 HUMAN EXPERIMENTATION

    2.7 DEFINITION AND PURPOSE OF EXPERIMENTATION

    2.8 INFORMED CONSENT

    2.9 REGULATION OF MEDICAL DEVICE INNOVATION

    2.10 MARKETING MEDICAL DEVICES

    2.11 ETHICAL ISSUES IN FEASIBILITY STUDIES

    2.12 ETHICAL ISSUES IN EMERGENCY USE

    2.13 ETHICAL ISSUES IN TREATMENT USE

    2.14 THE ROLE OF THE BIOMEDICAL ENGINEER IN THE FDA PROCESS

    EXERCISES

    SUGGESTED READING

    3. ANATOMY AND PHYSIOLOGY

    3.1 INTRODUCTION

    3.2 CELLULAR ORGANIZATION

    3.3 Tissues

    3.4 MAJOR ORGAN SYSTEMS

    3.5 HOMEOSTASIS

    EXERCISES

    SUGGESTED READING

    4. BIOMECHANICS

    4.1 INTRODUCTION

    4.2 BASIC MECHANICS

    4.3 MECHANICS OF MATERIALS

    4.4 VISCOELASTIC PROPERTIES

    4.5 CARTILAGE, LIGAMENT, TENDON, AND MUSCLE

    4.6 CLINICAL GAIT ANALYSIS

    4.7 CARDIOVASCULAR DYNAMICS

    Exercises

    SUGGESTED READING

    5. REHABILITATION ENGINEERING AND ASSISTIVE TECHNOLOGY

    5.1 INTRODUCTION

    5.2 THE HUMAN COMPONENT

    5.3 PRINCIPLES OF ASSISTIVE TECHNOLOGY ASSESSMENT

    5.4 PRINCIPLES OF REHABILITATION ENGINEERING

    5.5 PRACTICE OF REHABILITATION ENGINEERING AND ASSISTIVE TECHNOLOGY

    EXERCISES

    SUGGESTED READING

    6. BIOMATERIALS

    6.1 MATERIALS IN MEDICINE: FROM PROSTHETICS TO REGENERATION

    6.2 BIOMATERIALS: PROPERTIES, TYPES, AND APPLICATIONS

    6.3 LESSONS FROM NATURE ON BIOMATERIAL DESIGN AND SELECTION

    6.4 TISSUE–BIOMATERIAL INTERACTIONS

    6.5 GUIDING TISSUE REPAIR WITH BIO-INSPIRED BIOMATERIALS

    6.6 SAFETY TESTING AND REGULATION OF BIOMATERIALS

    6.7 APPLICATION-SPECIFIC STRATEGIES FOR THE DESIGN AND SELECTION OF BIOMATERIALS

    EXERCISES

    SUGGESTED READING

    7. TISSUE ENGINEERING

    7.1 WHAT IS TISSUE ENGINEERING?

    7.2 BIOLOGICAL CONSIDERATIONS

    7.3 PHYSICAL CONSIDERATIONS

    7.4 SCALING UP

    7.5 IMPLEMENTATION OF TISSUE ENGINEERED PRODUCTS

    7.6 FUTURE DIRECTIONS: FUNCTIONAL TISSUE ENGINEERING AND THE “-OMICS” SCIENCES

    7.7 CONCLUSIONS

    7.8 Glossary

    EXERCISES

    SUGGESTED READING

    8. BIOINSTRUMENTATION

    8.1 INTRODUCTION

    8.2 BASIC BIOINSTRUMENTATION SYSTEM

    8.3 CHARGE, CURRENT, VOLTAGE, POWER, AND ENERGY

    8.4 RESISTANCE

    8.5 LINEAR NETWORK ANALYSIS

    8.6 LINEARITY AND SUPERPOSITION

    8.7 THÉVENIN’S THEOREM

    8.8 INDUCTORS

    8.9 CAPACITORS

    8.10 A GENERAL APPROACH TO SOLVING CIRCUITS INVOLVING RESISTORS, CAPACITORS, AND INDUCTORS

    8.11 OPERATIONAL AMPLIFIERS

    8.12 TIME-VARYING SIGNALS

    8.13 ACTIVE ANALOG FILTERS

    8.14 BIOINSTRUMENTATION DESIGN

    Exercises

    SUGGESTED READING

    9. BIOMEDICAL SENSORS

    9.1 INTRODUCTION

    9.2 BIOPOTENTIAL MEASUREMENTS

    9.3 PHYSICAL MEASUREMENTS

    9.4 BLOOD GASES AND PH SENSORS

    9.5 BIOANALYTICAL SENSORS

    9.6 OPTICAL BIOSENSORS

    EXERCISES

    SUGGESTED READING

    10. BIOSIGNAL PROCESSING

    10.1 INTRODUCTION

    10.2 PHYSIOLOGICAL ORIGINS OF BIOSIGNALS

    10.3 CHARACTERISTICS OF BIOSIGNALS

    10.4 SIGNAL ACQUISITION

    10.5 FREQUENCY DOMAIN REPRESENTATION OF BIOLOGICAL SIGNALS

    10.5.5 Properties of the Fourier Transform

    10.6 LINEAR SYSTEMS

    10.7 SIGNAL AVERAGING

    10.8 WAVELET TRANSFORM AND SHORT-TIME FOURIER TRANSFORM

    10.9 ARTIFICIAL INTELLIGENCE TECHNIQUES

    EXERCISES

    SUGGESTED READING

    11. BIOELECTRIC PHENOMENA

    11.1 INTRODUCTION

    11.2 HISTORY

    11.3 NEURONS

    11.4 BASIC BIOPHYSICS TOOLS AND RELATIONSHIPS

    11.5 EQUIVALENT CIRCUIT MODEL FOR THE CELL MEMBRANE

    11.6 HODGKIN–HUXLEY MODEL OF THE ACTION POTENTIAL

    11.7 MODEL OF THE WHOLE NEURON

    EXERCISES

    SUGGESTED READING

    12. PHYSIOLOGICAL MODELING

    12.1 INTRODUCTION

    12.2 COMPARTMENTAL MODELING

    12.3 AN OVERVIEW OF THE FAST EYE MOVEMENT SYSTEM

    12.4 WESTHEIMER SACCADIC EYE MOVEMENT MODEL

    12.5 THE SACCADE CONTROLLER

    12.6 DEVELOPMENT OF AN OCULOMOTOR MUSCLE MODEL

    12.7 A LINEAR MUSCLE MODEL

    12.8 A LINEAR HOMEOMORPHIC SACCADIC EYE MOVEMENT MODEL

    12.9 A TRUER LINEAR HOMEOMORPHIC SACCADIC EYE MOVEMENT MODEL

    12.10 SYSTEM IDENTIFICATION

    EXERCISES

    SUGGESTED READING

    13. GENOMICS AND BIOINFORMATICS

    13.1 INTRODUCTION

    13.2 CORE LABORATORY TECHNOLOGIES

    13.3 CORE BIOINFORMATICS TECHNOLOGIES

    13.4 CONCLUSION

    EXERCISES

    SUGGESTED READING

    14. COMPUTATIONAL CELL BIOLOGY AND COMPLEXITY

    14.1 COMPUTATIONAL BIOLOGY

    14.2 THE MODELING PROCESS

    14.3 BIONETWORKS

    14.4 INTRODUCTION TO COMPLEXITY THEORY

    EXERCISES

    SUGGESTED READING

    15. RADIATION IMAGING

    15.1 INTRODUCTION

    15.2 EMISSION IMAGING SYSTEMS

    15.3 INSTRUMENTATION AND IMAGING DEVICES

    15.4 RADIOGRAPHIC IMAGING SYSTEMS

    EXERCISES

    SUGGESTED READING

    16. MEDICAL IMAGING

    16.1 INTRODUCTION

    16.2 DIAGNOSTIC ULTRASOUND IMAGING

    16.3 MAGNETIC RESONANCE IMAGING (MRI)

    16.4 COMPARISON OF IMAGING MODES

    EXERCISES

    SUGGESTED READING

    17. BIOMEDICAL OPTICS AND LASERS

    17.1 INTRODUCTION TO ESSENTIAL OPTICAL PRINCIPLES

    17.2 FUNDAMENTALS OF LIGHT PROPAGATION IN BIOLOGICAL TISSUE

    17.3 Physical Interaction of Light and Physical Sensing

    17.4 BIOCHEMICAL MEASUREMENT TECHNIQUES USING LIGHT

    17.5 Fundamentals of Photothermal Therapeutic Effects of Lasers

    17.6 FIBER OPTICS AND WAVEGUIDES IN MEDICINE

    17.7 BIOMEDICAL OPTICAL IMAGING

    EXERCISES

    SUGGESTED READING

    APPENDIX

    A.1 MATLAB

    A.2 Solving Differential Equations Using MATLAB

    A.3 BLOCK DIAGRAMS AND SIMULINK

    A.4 SIMULINK

    INDEX

Product details

  • No. of pages: 1144
  • Language: English
  • Copyright: © Academic Press 2005
  • Published: April 6, 2005
  • Imprint: Academic Press
  • eBook ISBN: 9780080473147

About the Authors

John Enderle

John Enderle is among the best known biomedical engineers in the world. He is Editor-in-Chief of the IEEE EMB Magazine (Engineering in Medicine and Biology Society, the key electrical systems-oriented BME society). An electrical engineer by training, he is a Fellow of the Institute of Electrical and Electronics Engineers (IEEE), a past-president of the IEEE Engineering in Medicine and Biology Society, and a Fellow of the American Institute for Medical and Biological Engineering (AIMBE). He is also an ABET program evaluator for bioengineering programs and a member of the American Society for Engineering Education.

Affiliations and Expertise

School of Engineering, University of Connecticut, Storrs, CT, USA

Joseph Bronzino

Joseph Bronzino is one of the most renowned biomedical engineers in the world. He is a former president of the IEEE Engineering in Medicine and Biology, and well-known educator. He is editor-in-chief of the Biomedical Engineering Handbook from CRC Press, and is currently editor of the Academic Press Series in Biomedical Engineering. He is the Vernon Roosa Professor of Applied Science at Trinity College in Hartford, Connecticut.

Affiliations and Expertise

Trinity College, Hartford, CT, USA

Susan Blanchard

Susan Blanchard is among the best known biomedical engineers in the world. She is the outgoing president of the IEEE Engineering in Medicine and Biology society.

Affiliations and Expertise

Founding Director, School of Engineering Florida Gulf Coast University Fort Myers, FL

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