Introduction to Basic Aspects of the Autonomic Nervous System

Introduction to Basic Aspects of the Autonomic Nervous System

Volume 1

6th Edition - July 15, 2022

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  • Authors: Otto Appenzeller, Guillaume Lamotte, Elizabeth Coon
  • Hardcover ISBN: 9780323955843
  • eBook ISBN: 9780323955850

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Introduction to Basic Aspects of the Autonomic Nervous System: Sixth Edition, Volume 1 is an all-encompassing reference on the autonomic nervous system's basic function, dysfunction, and pathology. This volume describes the anatomy of the autonomic nervous system and its role in the regulation of blood pressure, body temperature, respiration, micturition, digestion, and renal function. Additional chapters focus on the autonomic modulation of the neuroendocrine system, sexual function, and immunity. There is also a chapter on mummies and the autonomic nervous system. With these chapters, the readers will gain extensive knowledge of the autonomic nervous system's anatomy, functional organization, and neurochemistry, which is critical to care for patients with autonomic disorders and guide patient-oriented research.

Key Features

  • Provides an extensive reference on the autonomic nervous system and its crucial functions and dysfunction
  • Discusses all aspects of autonomic physiology and pathology
  • Outlines several physiological processes regulated by the autonomic nervous system, including thermoregulation, blood pressure, micturition, respiration, digestion, and renal function
  • Features chapters on the modulation of the neuroendocrine system, sexual function, immunity, and a new chapter on mummies and the autonomic nervous system


Neurologists, researchers, clinical practitioners, medical and graduate students in neuroscience and neurology

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Foreword
  • Acknowledgments
  • Introduction
  • Chapter 1. Autonomic anatomy, histology, and neurotransmission
  • Abstract
  • 1.1 Historical perspective
  • 1.2 Anatomy of the autonomic nervous system
  • 1.3 The intrinsic cardiac nervous system; its role in cardiac pacemaking and conduction
  • 1.4 Human sympathetic preganglionic vasomotor and sudomotor neurons
  • 1.5 The neurogenic control of the cutaneous circulation
  • 1.6 Neurotransmitters
  • 1.7 Peptides
  • 1.8 The neurogenic control of the circulation in skeletal muscles
  • 1.9 Shear stress and arterial lumen
  • 1.10 Catecholamines and neurologic disease
  • References
  • Chapter 2. Neurogenic control of the circulation, syncope, and hypertension
  • Abstract
  • 2.1 Neurogenic control of the circulation
  • 2.2 Syncope
  • 2.3 Hypertension
  • References
  • Chapter 3. Thermoregulation
  • Abstract
  • 3.1 Introduction
  • 3.2 Thermoregulatory pathway and peripheral thermoreceptors
  • 3.3 Vasomotor responses
  • 3.4 Local blood vessel changes and environmental temperature
  • 3.5 The hypothalamus
  • 3.6 The measurement of temperature
  • 3.7 Abnormalities of body temperature
  • 3.8 Temperature regulation during fever
  • 3.9 Temperature regulation and exercise
  • 3.10 Periodic fevers
  • 3.11 Peptides
  • 3.12 Sweating and thermoregulation
  • References
  • Further reading
  • Chapter 4. Autonomic modulation of the neuroendocrine system
  • Abstract
  • 4.1 The hypothalamus and neuroendocrine modulation
  • 4.2 The autonomic nervous system and the pineal gland
  • References
  • Chapter 5. Neurogenic control of respiration
  • Abstract
  • 5.1 Introduction
  • 5.2 The control of respiratory movements
  • 5.3 Pulmonary respiratory reflexes
  • 5.4 Breathlessness
  • 5.5 The nasal cycle
  • 5.6 The cerebrospinal fluid and the control of pulmonary ventilation
  • 5.7 Abnormalities in respiration related to disease of the nervous system
  • References
  • Chapter 6. The enteric nervous system
  • Abstract
  • 6.1 Introduction—anatomy and physiology
  • 6.2 Appetite, satiety, hunger, and the hypothalamus
  • 6.3 Normal swallowing and its disorders
  • 6.4 The stomach
  • 6.5 The intestine
  • 6.6 The rectum and defecation
  • 6.7 Vomiting
  • 6.8 Other reflexes
  • 6.9 Rectal biopsy in the diagnosis of neurological disease
  • 6.10 The irritable bowel syndrome
  • 6.11 Diarrhea and noninvasive secretagogues
  • 6.12 Idiopathic intestinal pseudoobstruction
  • 6.13 Enteric nervous system stem cell therapy for enteric neuropathies
  • 6.14 The gut–brain axis
  • References
  • Chapter 7. Autonomic modulation of immunity
  • Abstract
  • 7.1 Autonomic nervous system and inflammation
  • 7.2 Autonomic innervation of the main immune organs
  • 7.3 Effects of ablation experiments on the immune system
  • 7.4 Neural control of immunity in hypertension
  • 7.5 Multiple sclerosis and autonomic function
  • 7.6 Paraneoplastic syndromes and autonomic failure
  • 7.7 Experimental autonomic neuropathy
  • 7.8 Physical activity and nutritional influence on immune function
  • References
  • Chapter 8. Neurogenic control of sexual function
  • Abstract
  • 8.1 Innervation of sexual organs
  • 8.2 Central nervous system
  • 8.3 Sexual activity in females
  • 8.4 Sexual responses in males
  • 8.5 Neuroanatomical sex differences
  • 8.6 Sexual function in patients with nervous system lesions
  • References
  • Chapter 9. Neurogenic control of renal function
  • Abstract
  • 9.1 Introduction
  • 9.2 Sympathetic innervation of the kidneys
  • 9.3 Sensory renal nerves
  • 9.4 Regulation of renal sympathetic nerve activity
  • 9.5 Renal nerves in diseases
  • 9.6 Neural regulation of thirst and salt appetite
  • 9.7 The renin-angiotensin-aldosterone system
  • 9.8 Special considerations
  • References
  • Chapter 10. Neurogenic control of micturition
  • Abstract
  • 10.1 Introduction
  • 10.2 The anatomy of the bladder and urethra
  • 10.3 Muscles of the pelvic diaphragm and the perineum
  • 10.4 Peripheral innervation of the bladder and urethra
  • 10.5 Influences of the central nervous system on micturition
  • 10.6 Reflex micturition
  • 10.7 Voluntary micturition
  • 10.8 Pathology in humans
  • References
  • Chapter 11. The archeology of autonomic function
  • Abstract
  • 11.1 Diseases with autonomic nervous system involvement in mummy studies
  • 11.2 Paleoneurobiology
  • 11.3 Statistical methods in bioarchaeology
  • References
  • Index

Product details

  • No. of pages: 602
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: July 15, 2022
  • Imprint: Academic Press
  • Hardcover ISBN: 9780323955843
  • eBook ISBN: 9780323955850

About the Authors

Otto Appenzeller

Dr. Appenzeller MD, PhD is Professor Emeritus at the University of New Mexico in the Departments of Neurology and Medicine. He is also President of the New Mexico Health Enhancement and Marathon Clinics.

Affiliations and Expertise

University of New Mexico School of Medicine, and New Mexico Health Enhancement and Marathon Clinics Research Foundation, USA

Guillaume Lamotte

Dr. Lamotte is a practicing neurologist and Assistant Professor of Neurology Movement Disorders and Autonomic Disorders at the Department of Neurology at the University of Utah. He received his medical degree from the University of Caen in France in 2010 and completed a neurology residency at the University Hospital of Caen, France. He then completed a second neurology residency at Medstar Georgetown University Hospital in Washington, DC, and a fellowship in Autonomic Disorders at the Mayo Clinic in Rochester, MN. Dr. Lamotte’s research focuses on movements disorders and autonomic disorders.

Affiliations and Expertise

Assistant Professor of Neurology Movement Disorders and Autonomic Disorders, Department of Neurology, University of Utah, USA

Elizabeth Coon

Dr. Coon is an adult neurologist, with specialty interest in autonomic disorders and movement disorders. Board-certified in Neurology, she is Vice Chair of the American Academy of Neurology and also Vice Chair of the Examination Committee at the United Council for Neurological Subspecialties. She has won multiple awards, including the Don Summers Memorial Multiple System Atrophy Award from the American Autonomic Society, and the Lawrence C. McHenry Award (An Award for the History of Neurology) from the American Academy of Neurology.

Affiliations and Expertise

Mayo Clinic, USA

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