
Intrinsically Disordered Proteins
Dynamics, Binding, and Function
Description
Key Features
- Provides in-depth discussion of fundamental IDP and IDR dynamics, function, and binding, with mechanistic insight to support new drug development
- Describes the role of new computational and experimental approaches in characterizing the binding of IDPs to their functional targets
- Features chapter contributions from international experts in IDP and IDR biochemical function and methods of study
Readership
Active researchers and students in biochemistry, molecular biology, pharmaceutical science, cellular biology, applied microbiology, and biotechnology; medical chemists; clinician scientists
Table of Contents
1. Introduction to intrinsically disordered proteins and regions
PART I - Methodology
2. Ensemble descriptions of IDPs and IDRs: Integrating simulation and experiment
3. Experimental characterization of the dynamics of IDPs and IDRs by NMR
4. Single-molecule fluorescence studies of IDPs and IDRsPART II - Molecular Mechanism
5. Experimental studies of binding of intrinsically disordered proteins to their partners
6. Modeling protein-protein interactions with intrinsically disordered proteinsPART III - Biology and Medicine
7. IDPs and IDRs in biomolecular condensates
8. Molecular mechanisms of fibrillation of IDPs
9. Perspectives on drug discovery strategies based on IDPs
10. Conclusion and future directions
Product details
- No. of pages: 355
- Language: English
- Copyright: © Academic Press 2019
- Published: June 14, 2019
- Imprint: Academic Press
- Paperback ISBN: 9780128163481
- eBook ISBN: 9780128167328
About the Editor
Nicola Salvi
Affiliations and Expertise
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