Intrinsically Disordered Proteins - 1st Edition - ISBN: 9780128156490

Intrinsically Disordered Proteins, Volume 611

1st Edition

Serial Volume Editors: Elizabeth Rhoades
Hardcover ISBN: 9780128156490
Imprint: Academic Press
Published Date: 15th November 2018
Page Count: 412
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Table of Contents

1. Characterization of Structure-Function relationships in the intrinsically disordered protein complexin
David Eliezer
2. Distances, distance distributions, and ensembles of IDPs from single-molecule FRET
Ben Schuler
3. Biophysical characterization of disordered protein liquid phases
Shana Elbaum-Garfinkle
4. The Use of Mass Spectrometry to Examine IDPs – Unique Insights and Caveats
Perdita Elizabeth Barran
5. Fluorescence Depolarization Kinetics to Study Conformational Preference, Structural Plasticity and Membrane Binding of Intrinsically Disordered Proteins
Samrat Mukhopadhyay
6. Characterizing the Function of Intrinsically Disordered Proteins in the Circadian Clock
Jennifer Marie Hurley
7. Characterizing allostery in intrinsically disordered proteins
Vincent Hilser
8. The role of disorder in HP1 proteins in chromatin phase separation
Geeta Narlikar
9. Characterizing the role of residual helicity in binding of intrinsically disordered proteins
Gary Daughdrill
10. The use of carbon-detected NMR to characterize flexible and disordered proteins
Scott A. Showalter
11. How fuzzy can paramyxoviral NTAIL complexes be?
Monika Fuxreiter and Sonia Longhi
12. Structure-function characterization of large disordered proteins
Peter Tompa
13. Characterization of intrinsically disordered proteins in protein complexes
Birthe B. Krageland
14. Solvent dependent chain dynamics of disordered proteins using fluorescence correlation spectroscopy experiments in cuvettes
Kanchan Garai
15. Quanitative characterization of intrinsically disordered protein dynamics by photoinduced electron transfer (PET)
Sara Vaiana
16. Multiscale methods to uncover sequence-encoded driving forces for phase separation in proteins with intrinsically disordered regions
Rohit Pappu
17. Probing IDP conformations and dynamics with single-molecule fluorescence
Ashok Deniz
18. Characterization of IDP function in the nuclear pore
Edward A. Lemke
19. Characterizing the impact of intrinsically disordered proteins on membrane curvature
Jeanne Stochowiak
20. Novel materials from intrinsically disordered UBX
Sarah Bondos
21. Folding and binding of intrinsically disordered proteins
Sarah Shammas
22. Characterization of binding of small molecules to intrinsically disordered proteins
Steve Metallo
23. Characterizing the roles of intrinsically disordered proteins in cytoplasmic organization
Amy Gladfelter
24. Targeting dynamic amyloid states with small molecules
Andrew Miranker


Description

Intrinsically Disordered Proteins, Volume 611, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics of interest, including the Characterization of Structure-Function relationships in the intrinsically disordered protein complexin, Distances, distance distributions, and ensembles of IDPs from single-molecule FRET, Biophysical characterization of disordered protein liquid phases, The Use of Mass Spectrometry to Examine IDPs – Unique Insights and Caveats, Fluorescence Depolarization Kinetics to Study Conformational Preference, Structural Plasticity and Membrane Binding of Intrinsically Disordered Proteins, Characterizing the Function of Intrinsically Disordered Proteins in the Circadian Clock, and more.

Key Features

  • Breadth of experimental approaches and systems that will be covered
  • The expertise of the contributors writing the articles

Readership

Basic research scientists – biophysicists, biochemists, and biologists – who are studying systems where protein disorder is important to function or dysfunction.


Details

No. of pages:
412
Language:
English
Copyright:
© Academic Press 2018
Published:
Imprint:
Academic Press
Hardcover ISBN:
9780128156490

Ratings and Reviews


About the Serial Volume Editors

Elizabeth Rhoades Serial Volume Editor

Elizabeth Rhoades was born and raised in Huntsville, Alabama. As a child, she loved reading and when she left for college, she intended to major in English at Duke University. After taking a Physics course to fulfill a distribution requirement during her first year, she switched gears and decided to pursue a Physics major. In between her junior and senior years, she spent a summer at the University of Tennessee in a REU program, where she discovered biophysics. Liz earned her Ph.D. in 2001 from the Biophysics Research Division at the University of Michigan, working with Ari Gafni, a biophysical chemist, and Ducan Steel, a physicist, on understanding amyloid aggregation. It was in the Gafni-Steel lab that she became interested in understanding the physico-chemical basis of protein structure and dynamics and the power of fluorescence spectroscopy as a tool. She spent 2.5 years as a postdoctoral fellow with Gilad Haran at the Weizmann Institute, applying single molecule fluorescence to the study of protein folding, and then an additional 2.5 years as a postdoc in Watt Webb’s lab at Cornell University. In 2006, Liz joined the faculty in the Molecular Biophysics & Biochemistry Department at Yale University, where she rose through the academic ranks. She moved to the Chemistry Department at the University of Pennsylvania in 2016. In her independent career, her research focuses on understanding both functional and dysfunctional aspects of intrinsically disordered proteins, with a focus on several implicated in neurodegeneration. She has served as chair of the Intrinsically Disordered Protein Subgroup of the Biophysical Society and currently serves as Associate Editor of the Proteins section of the Biophysical Journal. Her husband is also a scientist/professor and she has two young sons who plan to be superheroes when they grow up.

Affiliations and Expertise

Associate Professor, Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA