Intracellular Signalling Proteins - 1st Edition - ISBN: 9780128155615

Intracellular Signalling Proteins, Volume 116

1st Edition

Serial Volume Editors: Rossen Donev
Hardcover ISBN: 9780128155615
Imprint: Academic Press
Published Date: 1st May 2019
Page Count: 488
Sales tax will be calculated at check-out Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Table of Contents

1. Voices from the Dead: The Complex Language of Dead Cells
Jerrold S Levine
2. Nucleobindins and Encoded Peptides: From Cell Signalling to Physiology
Suraj Unniappan
3. Estrogen receptor signaling mechanisms
Patricia Silveyra
4. Intracellular signaling of the AMP-activating protein kinase
Mentor Sopjani
5. Relationship between mitofusin 2 and cancer
Alessandro Allegra
6. Molecular signaling in bone cells: regulation cell differentiation and survival
Lilian Irene Plotkin
7. Activating mutations of the gp130/JAK/STAT pathway in human diseases
Christoph Garbers
8. The role of aquaporins in inflammation
Margherita Sisto
9. Intracellular signal transduction cascades in presynaptic neurons
Jaewon Ko
10. Dopamine signaling in the striatum
Emmanuel Valjent
11. Recent advances in computational studies of GPCR-G protein interactions
Yinglong Miao
12. Cell signaling by fragile X family proteins
Jean Martin Beaulieu


Intracellular Signalling Proteins, Volume 116, presents an overview of the current developments in mechanisms of intracellular signaling and involvement of these mechanisms in the development of a number of disorders and diseases. Opportunities for targeting the intracellular signaling cascades for benefiting patients are also discussed, along with chapters that focus on Voices from the Dead: The Complex Language of Dead Cells, Nucleobindins and Encoded Peptides: From Cell Signalling to Physiology, Estrogen Receptor Signaling Mechanisms, Intracellular Signaling of the AMP-Activating Protein Kinase, the Relationship between Mitofusin 2 and Cancer, Molecular Signaling in Bone Cells: Regulation Cell Differentiation and Survival, and more.

Key Features

  • Describes advances in the discovery and application of therapeutics that target intracellular signaling mechanisms
  • Targeted to a very wide audience of specialists, researchers and students
  • Contains timely chapters written by well-renowned authorities in their field
  • Includes a number of high quality illustrations, figures and tables


Protein chemists, molecular cell biologists, immunologists, structural biologists, medical doctors, pharmacologists, computational biochemists and other researchers working in this field. Articles published here would also be of great benefit to medical, biology and pharmacology students specializing in this field


No. of pages:
© Academic Press 2019
Academic Press
Hardcover ISBN:

Ratings and Reviews

About the Serial Volume Editors

Rossen Donev

Rossen Donev Serial Volume Editor

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2010 Dr. Donev was appointed Senior Lecturer in Swansea University. Currently he is Head of Research at MicroPharm Ltd, UK and Director of Biomed Consult, UK. He has published more than 60 research papers, has chaired scientific meetings in Molecular Medicine and given plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on design of antibody-based oral treatment of pathological conditions of the colon and small intestines.

Affiliations and Expertise

Swansea University, UK