Intracellular Signalling Proteins

Intracellular Signalling Proteins

1st Edition - April 8, 2019

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  • Editor: Rossen Donev
  • Hardcover ISBN: 9780128155615
  • eBook ISBN: 9780128155622

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Intracellular Signalling Proteins, Volume 116, presents an overview of the current developments in mechanisms of intracellular signaling and involvement of these mechanisms in the development of a number of disorders and diseases. Opportunities for targeting the intracellular signaling cascades for benefiting patients are also discussed, along with chapters that focus on Voices from the Dead: The Complex Language of Dead Cells, Nucleobindins and Encoded Peptides: From Cell Signalling to Physiology, Estrogen Receptor Signaling Mechanisms, Intracellular Signaling of the AMP-Activating Protein Kinase, the Relationship between Mitofusin 2 and Cancer, Molecular Signaling in Bone Cells: Regulation Cell Differentiation and Survival, and more.

Key Features

  • Describes advances in the discovery and application of therapeutics that target intracellular signaling mechanisms
  • Targeted to a very wide audience of specialists, researchers and students
  • Contains timely chapters written by well-renowned authorities in their field
  • Includes a number of high quality illustrations, figures and tables


Protein chemists, molecular cell biologists, immunologists, structural biologists, medical doctors, pharmacologists, computational biochemists and other researchers working in this field. Articles published here would also be of great benefit to medical, biology and pharmacology students specializing in this field

Table of Contents

  • 1. Voices from the dead: The complex language and intricate grammar of dead cells
    Jerrold S. Levine and David S. Ucker
    2. Nucleobindins and encoded peptides: From cell signaling to physiology
    Adelaine Leung, Naresh Ramesh, Christine Vogel and Suraj Unniappan
    3. Estrogen receptor signaling mechanisms
    Nathalie Fuentes and Patricia Silveyra
    4. Intracellular signaling of the AMP-activated protein kinase
    Miribane Dërmaku-Sopjani and Mentor Sopjani
    5. Relationship between mitofusin 2 and cancer
    Alessandro Allegra, Vanessa Innao, Andrea Gaetano Allegra and Caterina Musolino
    6. Molecular signaling in bone cells: Regulation of cell differentiation and survival
    Lilian I. Plotkin and Angela Bruzzaniti
    7. Activating mutations of the gp130/JAK/STAT pathway in human diseases
    Juliane Lokau and Christoph Garbers
    8. Aquaporin water channels: New perspectives on the potential role in inflammation
    Margherita Sisto, Domenico Ribatti and Sabrina Lisi
    9. Intracellular protein complexes involved in synapse assembly in presynaptic neurons
    Kyung Ah Han, Ji Won Um and Jaewon Ko
    10. Dopamine signaling in the striatum
    Emmanuel Valjent, Anne Biever, Giuseppe Gangarossa and Emma Puighermanal
    11. Recent advances in computational studies of GPCR-G protein interactions
    Jinan Wang and Yinglong Miao
    12. From traveler to homebody: Which signaling mechanisms sponge larvae use to become adult sponges?
    Ilya Borisenko, Olga I. Podgornaya and Alexander V. Ereskovsky

Product details

  • No. of pages: 462
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: April 8, 2019
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128155615
  • eBook ISBN: 9780128155622

About the Serial Volume Editor

Rossen Donev

Rossen Donev
Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.

Affiliations and Expertise

Head of Research, MicroPharm Limited, UK

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