Contents. List of Contributors. Preface (A.J. Rivett). Biochemical Properties and Biological Functions of ATP-Dependent Proteases in Bacterial Cells (M.R. Maurizi). From Proteasome to Lysosome: Studies on Yeast Demonstrate the Principles of Protein Degradation in the Eukaryote Cell (M. Thumm and D.H. Wolf). Cellular Regulation by Ubiquitin-Dependent Processes (K.D. Wilkinson). The 20s Proteasome: Subunits and Functions (K. Tanaka and N. Tanahashi). The 19s Regulatory Complex of the 26s Proteasome (W. Dubiel and M. Rechsteiner). Endoplasmic Reticulum0Associated Protein Degradation: an Unconventional Route to a Familiar Fate (A.A. McCracke, E.D. Werner, and J.L. Brodsky). Pathways for the Degradation of Intracellular Proteins within Lysosomes in Higher Eukaryotes (E. Knecht, J.J.M. de Llano, E.J. Andreu, and I.M. Miralles). The Critical Role of the Ubiquitin-proteasome Pathway in Muscle Wasting in Comparison to Lysosomal and Ca2+-dependent Systems (D. Attaix and D. Taillandier). Proteolysis in Apoptosis: Enzymes and Substrates (G.G.F. Mason, and J. Beyette). Index.