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Interorganellar Signaling in Age-Related Disease - 1st Edition - ISBN: 9780444504951

Interorganellar Signaling in Age-Related Disease, Volume 7

1st Edition

Editor: M.P. Mattson
Hardcover ISBN: 9780444504951
Imprint: Elsevier Science
Published Date: 19th April 2001
Page Count: 284
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Table of Contents

Peroxisomal alterations in aging and age-related disease (J. Youssef, M. Badr).
Perturbed calcium homeostasis in neurodegenerative disorders (M.P. Mattson).
Mitochondrial dysfunction in diabetes mellitus (M.F. Bauer, S. Hofmann, K.-D. Gerbitz).
Mitochondrial signaling and cancer (T.J. Preston, G. Singh).
Molecular chaperones and age-related degenerative disorders (A.J.L. Macario, E. Conway de Macario).
The role of telomerase in age-related degenerative disease and cancer (M. Fossel).
Mitochondrial oxidative stress and metabolic alterations in neurodegenerative disorders (J.N. Keller, G.W. Glazner).
Importance of proteasome-mediated proteolysis and alterations of the ubiquitin/proteasome pathway in cancer cells (V.J. Spataro, C.J. Norbury).
Contributors' addresses.


Collectively, the chapters in this work will provide the reader with novel insight into the inter-relationships of the function of different organelles in the sequences of events that lead to cellular dysfunction and degeneration in the aging human population. The chapters are rich in information for cell and molecular biologists pursuing studies of the different diseases covered. In addition, the clinician will find value in understanding mechanisms underlying age-related disease as such an understanding will lead to novel therapeutic approaches for an array of age-related diseases.


No. of pages:
© Elsevier Science 2001
19th April 2001
Elsevier Science
Hardcover ISBN:


@from:S.I.S. Rattan
@qu:...There are eight well-written chapters on a variety of age-related impairments and diseases.

Ratings and Reviews

About the Editor

M.P. Mattson

Affiliations and Expertise

Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center, Baltimore, MD, USA