International Review of Neurobiology - 1st Edition - ISBN: 9780123668516, 9781483144467

International Review of Neurobiology

1st Edition

Supplement 1

Editors: Carl C. Pfeiffer
eBook ISBN: 9781483144467
Imprint: Academic Press
Published Date: 28th December 1972
Page Count: 190
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International Review of Neurobiology, Supplement 1: Neurobiology of the Trace Metals Zinc and Copper represents a first report in the study of the neurobiology of zinc and copper. Topics covered by this supplementary volume include the effects of zinc deficiency; the link between acute stress and trace element metabolism; the effects of trace elements on behavior; the pathophysiology of zinc; and the role of copper in schizophrenia. This book consists of seven chapters and begins with a historical overview of zinc deficiency syndrome in humans, followed by a discussion on the metabolism of zinc, effects of its deficiency, and its biochemical functions. Gross congenital malformations in zinc-deficient rats are highlighted. The reader is then introduced to the effect of acute stress on the metabolism of a trace element; the importance of trace elements to development and behavior; and the biological effect(s) of zinc. The next chapter is devoted to idiopathic hypogeusia with dysgeusia, hyposmia, and dysosmia, its symptoms, clinical pathology, and treatment. This monograph will be of value to neurobiologists, biochemists, and nutritionists.

Table of Contents



Zinc Deficiency Syndrome in Man: A Historical Review



Congenital Malformations of the Nervous System in Zinc-Deficient Rats

I. Introduction

II. Gross Congenital Malformations in Zinc-Deficient Rats

III. Histopathology of Nervous System Malformations in Zinc Deficiency

IV. Concluding Remarks


Acute Stress and Trace Element Metabolism

I. Introduction

II. Magnesium

III. Iron

IV. Copper

V. Zinc

VI. Manganese

VII. Cobalt

VIII. Other Trace Elements

IX. General Conclusions


Trace Elements and Behavior

I. Introduction

II. Iron

III. Copper

IV. Manganese

V. Magnesium

VI. Zinc

VII. Discussion and Summary


Pathophysiology of Zinc

I. Introduction

II. Chemical Structure and Reactivity

III. Competition with Other Metals

IV. Zinc and the Stability of Macromolecules

V. Evidence for the Interaction of Zinc with Cell Plasma Membrane

VI. Zinc and Stability of Lysosomes

VII. Zinc and Mitochondria

VIII. Zinc and Lipid Peroxidation

IX. Relevance of the Findings on Zinc to the Problem of Carcinogenesis

X. Zinc and the Wound

XI. Zinc and Collagen Metabolism

XII. Concluding Remarks


Idiopathic Hypogeusia: A Description of the Syndrome and a Single-Blind Study with Zinc Sulfate

I. Introduction

II. Clinical History and Methods of Study

III. Discussion


A Study of Zinc Deficiency and Copper Excess in the Schizophrenias

I. Introduction

II. Historical

III. Copper Studies in Schizophrenia

IV. Use of D-Penicillamine in Schizophrenia

V. Methods

VI. Results

VII. Discussion


Author Index

Subject Index


No. of pages:
© Academic Press 1972
Academic Press
eBook ISBN:

About the Editor

Carl C. Pfeiffer

Affiliations and Expertise

Emory University, Atlanta, Georgia

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