International Review of Experimental Pathology

Kidney Disease

1st Edition - December 28, 1988
Editor: G. W. Richter
Language: English
eBook ISBN:
9 7 8 - 1 - 4 8 3 2 - 8 1 7 0 - 4

International Review of Experimental Pathology, Volume 30, is organized around the theme of renal disease. The choice of renal disease reflects both the author’s personal interest… Read more

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International Review of Experimental Pathology, Volume 30, is organized around the theme of renal disease. The choice of renal disease reflects both the author’s personal interest and the realization that there is a need for such a collection of reviews in this area. There are many new books on renal pathology, but almost all have a clinical rather than experimental orientation. The book opens with a chapter on the pathogenesis of experimentally induced renal papillary necrosis and upper urothelial carcinoma. Subsequent chapters deal with the use of cell cultures in the study of renal diseases; mechanisms of cyclosporine nephrotoxicity in humans and animal systems; spontaneously occurring renal diseases in laboratory animals; and the use of video microscopy to define the reactivity of the renal microvasculature and the hydraulic permeability of the glomerular capillaries. This book will be of interest to a diverse group of readers interested in renal disease. This broad spectrum of potential readership is reflected in the list of contributors which includes, in addition to pathologists, nephrologists, anatomists, veterinarians, and experimental chemists. This volume will also be of interest to transplant surgeons and to pediatricians specializing in renal disease.

Preface

Experimentally Induced Renal Papillary Necrosis and Upper Urothelial Carcinoma

I. Introduction

II. Renal Papillary Necrosis and Upper Urothelial Carcinoma in Humans

III. Experimentally Induced Renal Papillary Necrosis

IV. Use of Model Papillotoxic Probes to Study the Pathogenesis and Secondary Development of Renal Papillary Necrosis

V. Biochemical Interpretation of the Pathogenesis and Secondary Consequences of Renal Papillary Necrosis

VI. Renal Papillary Necrosis and Upper Urothelial Carcinoma

VII. Summary of the Pathogenesis of Experimentally Induced Renal Papillary Necrosis and Upper Urothelial Carcinoma

VIII. Remaining Questions

References

The Contribution of Cell Culture to the Study of Renal Diseases

I. Introduction

II. Glomerular Cell Culture

III. Tubular Cell Culture

References

Cyclosporine Nephrotoxicity

I. Introduction

II. Experimental Models of Cyclosporine Nephrotoxicity

III. Clinical Cyclosporine Nephrotoxicity

IV. Future Directions and Unanswered Questions

References

Glomerular Antigens in Experimental Glomerulonephritis

I. Models of Glomerulonephritis

II. Structure and Function of the Glomerulus

III. Immune Mechanisms in the Pathogenesis of Glomerulonephritis

IV Antigens in Experimental Glomerulonephritis

V Genetic Influences

VI. Conclusion

References

Spontaneous Renal Disease in Laboratory Animals

I. Introduction

II. Rat

III. Mouse

IV. Hamster

V Rabbit

VI. Guinea Pig

VII. Dog

VIII. Monkey

References

The Use of Video Imaging Techniques to Study Ultrafiltration and Blood Flow in the Normal and Diseased Kidney

I. Background

II. Documentation of Filtration by Isolated Glomeruli

III. Studies of Isolated Renal Microvessels

IV Observations of Glomeruli during In Situ Perfusion

V Studies of Blood-Perfused Juxtamedullary Nephrons

VI. Documentation of Medullary Blood Flow

VII. Prospects for the Future

References

Chemically Induced Renal Epithelial Neoplasia in Experimental Animals

I. Introduction

II. Renal Tubule Epithelial Cell Neoplasia

References

Index