International Review of Connective Tissue Research

International Review of Connective Tissue Research

Volume 4

1st Edition - January 1, 1968

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  • Editor: David A. Hall
  • eBook ISBN: 9781483195025

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International Review of Connective Tissue Research covers a broad range of aspects of connective tissue metabolism and structure, and other relevant material in the field of connective tissue research. The book discusses topics on the immunological reactions of collagen macromolecules and their degradation products; the factors involved in the specific control of collagen protein synthesis; effect of ionizing radiation on connective tissue components; and the physical properties of connective tissue. Physiologists, pathologists and researchers in the field of medicine will find the book invaluable.

Table of Contents

  • Contributors Preface

    Contents of Previous Volumes

    Tentative Contents of Subsequent Volumes

    Immunology of Collagen

    I. Introduction

    II. Collagen Purity and Immunological Specificity

    III. Amino Acid Composition and Structure of Collagen

    IV. Antigenicity of Collagen and Collagen Derivatives

    V. Antigenicity of Synthetic Polypeptides Related to Collagen

    VI. Antigenicity of Gelatin and Gelatin Derivatives

    VII. Immunological Relationships of Collagen and Other Components of Connective Tissue

    VIII. Auto- and Isoantibodies to Collagen in Diseases of Connective Tissue

    IX. Pathogenicity of Anticollagen Antibodies

    X. Summary and Conclusions


    Collagen Biosynthesis at the Ribosomal Level

    I. Collagen-Nucleic Acid Complexes

    II. Ribonucleic Acid and Collagen Synthesis

    III. Collagen Formation on Polyribosomes

    IV. Messenger Ribonucleic Acid

    V. The Substrate for Hydroxylation


    Control of Collagen Biosynthesis


    I. Conditions for the Specific Control of Biosynthesis of Collagenous Proteins

    II. Relation of Intermediary Metabolism to Collagen Synthesis

    III. Effect of Proline, Its Analogs, and Other Amino Acids on Collagen Protein Synthesis

    IV. Antibiotics and Collagen Synthesis

    V. Metals and Collagen Synthesis

    VI. Effect of Chelating Agents

    VII. Hydroxyproline- and Hydroxylysine-Deficient Collagen

    VIII. Collagen Hydroxylase

    IX. Ascorbic Acid as the Factor Controlling Protein Synthesis

    X. Influence of the Partial Tension of Oxygen

    XI. Further Reagents Controlling Collagen Formation

    XII. Conclusion

    XIII. Appendix: Formulas of Substances Discussed


    Copper and Connective Tissue Metabolism

    I. Introduction

    II. The Metabolic Role of Copper

    III. The Connective Tissues in Copper Deficiency

    IV. Biogenesis of Connective Tissues

    V. Relation of Copper to Connective Tissue Metabolism


    Effect of Ionizing Radiation on Connective Tissue Components

    I. Introduction

    II. Interaction of Ionizing Radiation with Matter

    III. Irradiation of Fibrous Connective Tissue

    IV. Irradiation of Ground Substance

    V. Irradiation of Cellular Components

    VI. Aging and Radiation

    VII. Chemical Protection of Tissues against Radiation

    VIII. Concluding Remarks


    Physical Properties of Collagen Fibers

    I. Introduction

    II. Crystalline Collagen

    III. Hydration

    IV. Mechanical Properties

    V. Noncrystalline Collagen

    VI. Summary


    Author Index

    Subject Index

Product details

  • No. of pages: 392
  • Language: English
  • Copyright: © Academic Press 1968
  • Published: January 1, 1968
  • Imprint: Academic Press
  • eBook ISBN: 9781483195025

About the Editor

David A. Hall

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