International Review of Connective Tissue Research

International Review of Connective Tissue Research

Volume 1

1st Edition - January 1, 1963

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  • Editor: M. A. Epstein
  • eBook ISBN: 9781483195032

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International Review of Connective Tissue Research, Volume 1 is a collection of papers that deals with fibroblast, the hormonal control of connective tissues, and calcification of skeletal tissues. One paper reports on the origin, morphology, structure, and the effect of drugs on fibroblasts such as the toxic substance found in sweet pea meal that causes human lathryrism. Another paper discuses hormonal control of connective tissue related to aging, arteriosclerosis, tumors, infection, fertility, and endocrine diseases. The author also describes the repair process of an injured connective tissue; it is characterized by edema, mucinous, and fibrous organization of the extracellular water—a process similar to regeneration and growth. One author describes the structure and general distribution of susceptible blood vessels, as well as, vascular degeneration in diabetes. Another author describes the calcification and formation of bones. He reviews Robison's theory of calcification, the seeding or nucleation concept of calcification, and the role of alkaline phosphatase in calcification. This volume will prove valuable for pathologists, endocrinologists, physiologists, molecular or cellular biologists, gerontologists, and researchers in gene therapy, pharmacology or micro-chemistry.

Table of Contents

  • Contributors


    The Fibroblast

    I. Origin, Morphology, and Structure

    II. Interrelationship of Fibroblasts with Other Connective Tissue Cells

    III. Function of Fibroblasts

    IV. Enzymes and Fibroblasts

    V. Fibroblasts and Hormones

    VI. The Effect of Drugs on Fibroblasts

    VII. Disorders of Function

    VIII. Response of Fibroblasts to Injury

    IX. Fibroblasts and Malignant Disease

    X. Tissue Culture in Fibroblast Research


    The Hormonal Control of Connective Tissue

    I. Connective Tissue

    II. Hormones and Their Tissue Targets

    III. Aging of Connective Tissue

    IV. Arteriosclerosis

    V. Regeneration, Repair, and Growth

    VI. Tumors

    VII. Infection

    VIII. Inflammation

    IX. Fertility and Reproduction

    X. Endocrine Diseases

    XI. Hormone Therapy


    Chemical Aspects of Collagen Fibrillogenesis

    I. Introduction

    II. The Nature and Distribution of Collagen Fibers

    III. Chemical Composition of Collagen Fibers

    IV. The Structure of Collagen Fibers

    V. Properties of Tropocollagen

    VI. Aggregation of Tropocollagen In Vitro

    VII. The Biosynthesis of Collagen

    VIII. The Induction of Collagen Fiber Formation In Vivo

    IX. Tropocollagen as a Precursor of Collagen Fiber in Biological Systems

    X. Collagen Formation as a Problem in Protein Synthesis

    XI. Summary


    Molecular Structure of Collagen

    I. General Survey

    II. Main Properties of Collagen

    III. Structure at the Molecular Level in the Fiber

    IV. Structure at the Electron Microscope Level

    V. Structure in Solution

    VI. Related Proteins and Crystallization on Collagen


    The Enzymes of The Elastase Complex

    I. Introduction

    II. Elastoproteinase (E2, Real Elastase, Proteolytic Elastase Component)

    III. Elastomucase (Elf Elastomucoproteinase, Mucolytic Elastase Component)

    IV. The Elastase Inhibition

    V. The Mechanism of Elastolysis

    VI. The Structure of Elastic Fibers and Elastic Tissue as Revealed by the Enzymes of the Elastase Complex

    VII. The Possible Implications of the Enzymes of the Elastase Complex in Aging and Selected Diseases, Especially the Process of Atherosclerosis


    Connective Tissue changes in Atherosclerosis

    I. Delineation of Atherosclerosis

    II. Nutrition of the Arterial Walls

    III. Arterial Endothelium in Atherosclerosis

    IV. The Primary Lesion of Atherosclerosis

    V. Elastic Tissue in Atherosclerosis

    VI. Elastase and Atherosclerosis

    VII. Further Development of Atherosclerosis from the Primary Lesions

    VIII. Collagen Fibers in Atherosclerosis

    IX. Mucopolysaccharides in Atherosclerosis

    X. Changes in the Muscular Layer of Arteries in Atherosclerosis

    XI. Calcification

    XII. Concluding Remarks


    Diabetes and Vascular Degeneration

    I. Introduction

    II. Vascular Degeneration in Diabetes

    III. Discussion


    Calcification of Skeletal Tissues

    I. Introduction

    II. Calcification and Formation of Bones

    III. Mechanism of Calcification


    Author Index

    Subject Index

Product details

  • No. of pages: 416
  • Language: English
  • Copyright: © Academic Press 1963
  • Published: January 1, 1963
  • Imprint: Academic Press
  • eBook ISBN: 9781483195032

About the Editor

M. A. Epstein

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