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International Review of Connective Tissue Research - 1st Edition - ISBN: 9781483167558, 9781483195032

International Review of Connective Tissue Research

1st Edition

Volume 1

Editor: M. A. Epstein
eBook ISBN: 9781483195032
Imprint: Academic Press
Published Date: 1st January 1963
Page Count: 416
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International Review of Connective Tissue Research, Volume 1 is a collection of papers that deals with fibroblast, the hormonal control of connective tissues, and calcification of skeletal tissues. One paper reports on the origin, morphology, structure, and the effect of drugs on fibroblasts such as the toxic substance found in sweet pea meal that causes human lathryrism. Another paper discuses hormonal control of connective tissue related to aging, arteriosclerosis, tumors, infection, fertility, and endocrine diseases. The author also describes the repair process of an injured connective tissue; it is characterized by edema, mucinous, and fibrous organization of the extracellular water—a process similar to regeneration and growth. One author describes the structure and general distribution of susceptible blood vessels, as well as, vascular degeneration in diabetes. Another author describes the calcification and formation of bones. He reviews Robison's theory of calcification, the seeding or nucleation concept of calcification, and the role of alkaline phosphatase in calcification. This volume will prove valuable for pathologists, endocrinologists, physiologists, molecular or cellular biologists, gerontologists, and researchers in gene therapy, pharmacology or micro-chemistry.

Table of Contents



The Fibroblast

I. Origin, Morphology, and Structure

II. Interrelationship of Fibroblasts with Other Connective Tissue Cells

III. Function of Fibroblasts

IV. Enzymes and Fibroblasts

V. Fibroblasts and Hormones

VI. The Effect of Drugs on Fibroblasts

VII. Disorders of Function

VIII. Response of Fibroblasts to Injury

IX. Fibroblasts and Malignant Disease

X. Tissue Culture in Fibroblast Research


The Hormonal Control of Connective Tissue

I. Connective Tissue

II. Hormones and Their Tissue Targets

III. Aging of Connective Tissue

IV. Arteriosclerosis

V. Regeneration, Repair, and Growth

VI. Tumors

VII. Infection

VIII. Inflammation

IX. Fertility and Reproduction

X. Endocrine Diseases

XI. Hormone Therapy


Chemical Aspects of Collagen Fibrillogenesis

I. Introduction

II. The Nature and Distribution of Collagen Fibers

III. Chemical Composition of Collagen Fibers

IV. The Structure of Collagen Fibers

V. Properties of Tropocollagen

VI. Aggregation of Tropocollagen In Vitro

VII. The Biosynthesis of Collagen

VIII. The Induction of Collagen Fiber Formation In Vivo

IX. Tropocollagen as a Precursor of Collagen Fiber in Biological Systems

X. Collagen Formation as a Problem in Protein Synthesis

XI. Summary


Molecular Structure of Collagen

I. General Survey

II. Main Properties of Collagen

III. Structure at the Molecular Level in the Fiber

IV. Structure at the Electron Microscope Level

V. Structure in Solution

VI. Related Proteins and Crystallization on Collagen


The Enzymes of The Elastase Complex

I. Introduction

II. Elastoproteinase (E2, Real Elastase, Proteolytic Elastase Component)

III. Elastomucase (Elf Elastomucoproteinase, Mucolytic Elastase Component)

IV. The Elastase Inhibition

V. The Mechanism of Elastolysis

VI. The Structure of Elastic Fibers and Elastic Tissue as Revealed by the Enzymes of the Elastase Complex

VII. The Possible Implications of the Enzymes of the Elastase Complex in Aging and Selected Diseases, Especially the Process of Atherosclerosis


Connective Tissue changes in Atherosclerosis

I. Delineation of Atherosclerosis

II. Nutrition of the Arterial Walls

III. Arterial Endothelium in Atherosclerosis

IV. The Primary Lesion of Atherosclerosis

V. Elastic Tissue in Atherosclerosis

VI. Elastase and Atherosclerosis

VII. Further Development of Atherosclerosis from the Primary Lesions

VIII. Collagen Fibers in Atherosclerosis

IX. Mucopolysaccharides in Atherosclerosis

X. Changes in the Muscular Layer of Arteries in Atherosclerosis

XI. Calcification

XII. Concluding Remarks


Diabetes and Vascular Degeneration

I. Introduction

II. Vascular Degeneration in Diabetes

III. Discussion


Calcification of Skeletal Tissues

I. Introduction

II. Calcification and Formation of Bones

III. Mechanism of Calcification


Author Index

Subject Index


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© Academic Press 1963
1st January 1963
Academic Press
eBook ISBN:

About the Editor

M. A. Epstein

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