International Review of Connective Tissue Research

International Review of Connective Tissue Research

Volume 2

1st Edition - January 1, 1964

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  • Editor: M. A. Epstein
  • eBook ISBN: 9781483194998

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International Review of Connective Tissue Research, Volume 2 is a collection of papers that deals with the morphological background, physiological, and pathological aspects of studies done on connective tissues. One paper discusses the precipitation of collagen fibers from solution — that fibrils form in vitro and in vivo by similar mechanisms. Another paper examines the importance of elastic tissues in the reactions of connective tissue including diseases of the vascular and pulmonary systems. As simple as elastic tissues appear to be, these can be models in studies of the basic structure and function of other more complicated tissues. One author discusses the physiology of the connective tissues of the reproductive tract; he concludes that defects in the connective tissue functions can cause failure in ovulation or the formation of cystic ovaries. Other authors discuss the diseases of collagen and related tissues (rheumatic fever, rheumatoid arthritis, systemic lupus erythematous, osteoarthritis, osteoporosis), as well as the aging process. One author analyzes the role of collagen fibers in aging: whether factors exist that causes cross-linking or ester cross-links or the dissolution of the collagen macromolecule associated with the aging of collagen. This book can prove helpful for molecular or cellular biologists, pathologists, physiologists, gerontologists, and researchers in gene therapy, pharmacology or micro-chemistry.

Table of Contents

  • Contributors


    The Precipitation Of Collagen Fibers From Solution

    I. Introduction

    II. Historical

    III. The Nature of Collagen Solutions

    IV. Modes of Aggregation of Collagen

    V. Formation of "Native-Type" Fibrils

    VI. Stability of Precipitated Collagen

    VII. Biological Implications


    Elastic tissue

    I. Introduction

    II. Definition

    III. History

    IV. Phylogeny

    V. Ontogeny

    VI. Anatomy

    VII. Physicochemical Properties

    VIII. Morphochemical Structure

    IX. Histogenesis

    X. Metabolism

    XI. Pathological Conditions Involving Elastin

    XII. Summary


    Chemistry and Metabolism of Connective Tissue Glycosam Inoglycans (Mucopolysaccharides)

    I. Introduction

    II. Hyaluronic Acid

    III. Dermatan Sulfate

    IV. Chondroitin Sulfates

    V. Keratan Sulfate

    VI. Heparin and Heparan Sulfates

    VII. Separation Methods

    VIII. Synthesis

    IX. Excretion


    The Physiology of the Connective Tissues of the Reproductive Tract

    I. General Introduction

    II. Components of Connective Tissues

    III. The Connective Tissues of the Reproductive Tract

    IV. The Uterus

    V. Connective Tissues of the Birth Canal

    VI. The Placenta and Fetal Membranes

    VII. The Connective Tissues of the Ovary

    VIII. Conclusions


    Diseases of Collagen and Related Tissues

    I. Constituents of Connective Tissue

    II. The Concept of "Collagen" or "Connective Tissue" Disease

    III. Morbid Anatomy of Connective Tissue Injury

    IV. An Etiological Classification of Diseases of Connective Tissue

    V. Connective Tissue Diseases with Evidence of Immunological Disturbance

    VI. Genetically Determined Diseases of Connective Tissue

    VII. Connective Tissue Diseases without Evidence of Immunological Disturbance or a Significant Genetic Determinant


    Aging of the Collagen Fiber

    I. The Fiber

    II. Isotonic Thermal Contraction as a Measure of Biological Age of the Fiber

    III. Isometric Method of Tension Measurement

    IV. Chemical Contraction

    V. Physical and Chemical Changes during Contraction

    VI. The Hydroxyproline Test for Aging

    VII. Influence of Different Substances on Cross-Links of the Fiber

    VIII. Changes in Cross-Links During Aging

    IX. Summary


    Mucopolysaccharides, Collagen, and Nonfibrillar Proteins in Inflammation

    I. Analytical Data

    II. Summary

    III. Conclusions


    Author Index

    Subject Index

Product details

  • No. of pages: 364
  • Language: English
  • Copyright: © Academic Press 1964
  • Published: January 1, 1964
  • Imprint: Academic Press
  • eBook ISBN: 9781483194998

About the Editor

M. A. Epstein

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