International Review of Cell and Molecular Biology - 1st Edition - ISBN: 9780128001776, 9780128003114

International Review of Cell and Molecular Biology, Volume 313

1st Edition

Editors: Kwang Jeon
eBook ISBN: 9780128003114
Hardcover ISBN: 9780128001776
Imprint: Academic Press
Published Date: 26th October 2014
Page Count: 276
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Table of Contents

  • International Review of Cell and Molecular Biology
    • Series Editors
    • Editorial Advisory Board
  • Chapter One. Lipidomics Applications for Discovering Biomarkers of Diseases in Clinical Chemistry
    • 1. Introduction
    • 2. Definition, Classification, and Biological Function of Lipids
    • 3. Lipidomics Methodology
    • 4. Applications of Lipidomics in Clinical Disease Biomarker Discovery
    • 5. Concluding Remarks and Perspectives
  • Chapter Two. Enzymatically Synthesized Inorganic Polymers as Morphogenetically Active Bone Scaffolds: Application in Regenerative Medicine
    • 1. Introduction
    • 2. Bone Scaffolds
    • 3. Bone Cells
    • 4. Biogenic, Morphogenetically Active Inorganic Polymers
    • 5. Enzymes Controlling the Synthesis of Morphogenetically Active Inorganic Polymers: A Paradigm Shift in Bioinorganic Chemistry
    • 6. Biocalcite as Bioseed during Mammalian HA Formation
    • 7. CA Activators as Potential Novel Drugs to Stimulate Bone Mineral Formation
    • 8. ALP Activators—Potential Novel Compounds to Stimulate Bone Mineral Formation?
    • 9. Applications for Bioprinting Organs
    • 10. Concluding Remarks
  • Chapter Three. New Insights into the Mechanism for VACM-1/cul5 Expression in Vascular Tissue in vivo
    • 1. Introduction
    • 2. Ubiquitin–Proteasome System and VACM-1/cul5
    • 3. Tissue-Specific Expression of VACM-1/cul5
    • 4. Impact of Hydration Status on VACM-1/cul5 and Aquaporins
    • 5. Summary
  • Chapter Four. The UNC-45 Myosin Chaperone: From Worms to Flies to Vertebrates
    • 1. Introduction and Overview
    • 2. Model Organism-Based Studies of UNC-45 Function
    • 3. X-Ray Crystal Structures of UCS Proteins
    • 4. Interactions, Mechanisms of Action, and Human Diseases
    • 5. Concluding Remarks
    • Note Added in Proof
    • Dedication
  • Chapter Five. Cell and Molecular Biology of Epidermal Growth Factor Receptor
    • 1. Introduction
    • 2. Background
    • 3. Fundamental Mechanisms of EGFR Signaling
    • 4. Regulatory Mechanisms that Modulate EGFR Signaling
    • 5. Concluding Remarks
  • Chapter Six. Centrosomes and the Art of Mitotic Spindle Maintenance
    • 1. Introduction
    • 2. Centrosome
    • 3. Amphiastral Mitotic Spindle Assembly
    • 4. Acentriolar Mitosis
    • 5. Chromosome Instability
    • 6. Conclusions
  • Chapter Seven. Dual Roles of Orphan Nuclear Receptor TR3/Nur77/NGFI-B in Mediating Cell Survival and Apoptosis
    • 1. Introduction
    • 2. Dual Roles of Nur77 in Various Cells
    • 3. Stimuli that Regulate Apoptosis/Survival via Nur77
    • 4. Downstream Targets of Nur77
    • 5. Signaling Pathways Involved in Nur77 Activity
    • 6. Apoptotic Pathways Involved in Nur77-Mediated Apoptosis
    • 7. Concluding Remarks
  • Index


International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth.

The series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists.

Key Features

  • Authored by some of the foremost scientists in the field
  • Provides comprehensive reviews and current advances
  • Wide range of perspectives on specific subjects
  • Valuable reference material for advanced undergraduates, graduate students and professional scientists


Cell biologists, molecular biologists, developmental biologists, physiologists (organ level), biomedical scientists, biochemists studying cell-cell interactions as well as cell variation and evolution, students and researchers.


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© Academic Press 2014
Academic Press
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About the Editors

Kwang Jeon

Kwang Jeon Editor

Kwang Jeon received his Ph.D. in cell physiology at King’s College, University of London, UK, in 1964 and taught at SUNY Buffalo and University of Tennessee. His research was concerned with the biogenesis and function of cell components in two major areas: Integration of intracellular symbionts into host cells leading to the acquisition of new cell components and cell variation; Membrane-protein recycling during endo- and exocytosis.

Affiliations and Expertise

University of Tennessee, Knoxville, TN, USA