
International Review of Cell and Molecular Biology
Description
Key Features
- Publishes only invited review articles on selected topics
- Authored by established and active cell and molecular biologists, drawn from international sources
- Offers a wide range of perspectives on specific subjects
Readership
The IRCMB series covers all fields of cell and molecular biology. IRCMB articles are addressed to a very wide public, ranging from undergraduate and graduate students to experienced scientists in a specific field
Table of Contents
Chapter One: Breast Cancer Immunology and Immunotherapy: Current Status and Future Perspectives
- Abstract
- 1 Introduction
- 2 Mechanisms of the Immune Response Inhibition in BC: Role of MDSCs and Regulatory T Cells
- 3 Immune System in the Therapeutic Response in BC. The Immunogenic Cell Death
- 4 T-Infiltrating Lymphocytes Molecular and Genomic Characterization as a Strategic Tool to Better Understand BC Behavior
- 5 Neoantigen Prediction: Genomic Tools for Personalized Immunotherapy
- 6 Immunotherapeutic Approaches in BC. Clinical Trials With Immune Checkpoint Inhibitors
- 7 Conclusions
- Acknowledgments
Chapter Two: New Insights Into Cellular Stress Responses to Environmental Metal Toxicants
- Abstract
- 1 Introduction
- 2 ER Stress and UPR
- 3 Metal-Induced ER Stress
- 4 ER Stress and Its Impact on Oxidative Stress
- 5 Genomics Approaches in Metal-Induced Cell Stress Studies
- 6 Conclusions and Future Directions
- Acknowledgments
Chapter Three: An Update on Src Family of Nonreceptor Tyrosine Kinases Biology
- Abstract
- 1 Introduction
- 2 Regulation of SFKs Function
- 3 Redox-Dependent Regulation of SFK Function
- 4 Role of SFKs in PRL Signaling
- 5 Relevance of SFKs in Breast Cancer
- 6 Role of SFKs During Mammalian Embryo Development and in the Regulation of Embryonic and Somatic Stem Cells
- 7 Conclusions
- Acknowledgments
Chapter Four: STAT Transcription Factors in T Cell Control of Health and Disease
- Abstract
- 1 Engagement of the Jak-STAT Signaling Pathway
- 2 Jak-STAT Molecules in T Helper Cell Differentiation
- 3 STAT Molecules in the Development of Cytotoxic T Cells
- 4 STATs Mutations Result in Patient Immunodeficiency
- 5 STAT Molecules in Allergic Inflammation
- 6 Role of STAT Molecules in Intestinal Inflammation
- 7 Jak-STAT Molecules in Autoimmune Diseases
- 8 Blocking Cytokine Signaling to Treat Disease
- 9 Conclusion
Chapter Five: Chemokine Receptor Signaling and the Hallmarks of Cancer
- Abstract
- 1 Introduction
- 2 The Chemokine Superfamily
- 3 Chemokine Activity on Neoplastic Cells
- 4 Chemokine Activities on Stromal Cells
- 5 Concluding Remarks
- Acknowledgments
Chapter Six: Mitochondrion: A Common Organelle for Distinct Cell Deaths?
- Abstract
- 1 Introduction
- 2 Apoptosis
- 3 MPT-Driven Necrosis
- 4 Mitophagy
- 5 Implication of Mitophagy in Models of Neurological Diseases
- 6 Implication of Mitochondria-Dependent Cell Death in Cardiac Diseases
- 7 Conclusion and Perspectives
- Acknowledgments
Chapter Seven: Antibody-Based Cancer Therapy: Successful Agents and Novel Approaches
- Abstract
- 1 Introduction
- 2 Monoclonal Antibodies
- 3 Effector Mechanisms and Activity of Tumor-Targeting Antibodies
- 4 Immunomodulatory Antibodies
- 5 Antibody Engineering to Improve Effector Functions
- 6 Alternative Antibody Formats
- 7 Antibody-Drug Conjugates
- 8 Antibody-Cytokine Fusion Proteins
- 9 CAR-Transfected T Cells
- 10 Conclusions
Product details
- No. of pages: 396
- Language: English
- Copyright: © Academic Press 2017
- Published: March 15, 2017
- Imprint: Academic Press
- Hardcover ISBN: 9780128124697
- eBook ISBN: 9780128124703
About the Serial Editor
Lorenzo Galluzzi

Affiliations and Expertise
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