International Review of Cell and Molecular Biology, Volume 331

Chapter One: Breast Cancer Immunology and Immunotherapy: Current Status and Future Perspectives

• Abstract
• 1 Introduction
• 2 Mechanisms of the Immune Response Inhibition in BC: Role of MDSCs and Regulatory T Cells
• 3 Immune System in the Therapeutic Response in BC. The Immunogenic Cell Death
• 4 T-Infiltrating Lymphocytes Molecular and Genomic Characterization as a Strategic Tool to Better Understand BC Behavior
• 5 Neoantigen Prediction: Genomic Tools for Personalized Immunotherapy
• 6 Immunotherapeutic Approaches in BC. Clinical Trials With Immune Checkpoint Inhibitors
• 7 Conclusions
• Acknowledgments

Chapter Two: New Insights Into Cellular Stress Responses to Environmental Metal Toxicants

• Abstract
• 1 Introduction
• 2 ER Stress and UPR
• 3 Metal-Induced ER Stress
• 4 ER Stress and Its Impact on Oxidative Stress
• 5 Genomics Approaches in Metal-Induced Cell Stress Studies
• 6 Conclusions and Future Directions
• Acknowledgments

Chapter Three: An Update on Src Family of Nonreceptor Tyrosine Kinases Biology

• Abstract
• 1 Introduction
• 2 Regulation of SFKs Function
• 3 Redox-Dependent Regulation of SFK Function
• 4 Role of SFKs in PRL Signaling
• 5 Relevance of SFKs in Breast Cancer
• 6 Role of SFKs During Mammalian Embryo Development and in the Regulation of Embryonic and Somatic Stem Cells
• 7 Conclusions
• Acknowledgments

Chapter Four: STAT Transcription Factors in T Cell Control of Health and Disease

• Abstract
• 1 Engagement of the Jak-STAT Signaling Pathway
• 2 Jak-STAT Molecules in T Helper Cell Differentiation
• 3 STAT Molecules in the Development of Cytotoxic T Cells
• 4 STATs Mutations Result in Patient Immunodeficiency
• 5 STAT Molecules in Allergic Inflammation
• 6 Role of STAT Molecules in Intestinal Inflammation
• 7 Jak-STAT Molecules in Autoimmune Diseases
• 8 Blocking Cytokine Signaling to Treat Disease
• 9 Conclusion

Chapter Five: Chemokine Receptor Signaling and the Hallmarks of Cancer

• Abstract
• 1 Introduction
• 2 The Chemokine Superfamily
• 3 Chemokine Activity on Neoplastic Cells
• 4 Chemokine Activities on Stromal Cells
• 5 Concluding Remarks
• Acknowledgments

Chapter Six: Mitochondrion: A Common Organelle for Distinct Cell Deaths?

• Abstract
• 1 Introduction
• 2 Apoptosis
• 3 MPT-Driven Necrosis
• 4 Mitophagy
• 5 Implication of Mitophagy in Models of Neurological Diseases
• 6 Implication of Mitochondria-Dependent Cell Death in Cardiac Diseases
• 7 Conclusion and Perspectives
• Acknowledgments

Chapter Seven: Antibody-Based Cancer Therapy: Successful Agents and Novel Approaches

• Abstract
• 1 Introduction
• 2 Monoclonal Antibodies
• 3 Effector Mechanisms and Activity of Tumor-Targeting Antibodies
• 4 Immunomodulatory Antibodies
• 5 Antibody Engineering to Improve Effector Functions
• 6 Alternative Antibody Formats
• 7 Antibody-Drug Conjugates
• 8 Antibody-Cytokine Fusion Proteins
• 9 CAR-Transfected T Cells
• 10 Conclusions

International Review of Cell and Molecular Biology reviews and details current advances in cell and molecular biology. This most current release in this highly cited series focuses on such timely topics as novel treatments in immunotherapy in breast cancer, chemokine receptor signaling and the hallmarks of cancer, tumor-targeting antibodies, and a section on mitochondrion and whether they are a common organelle for cell death. As always, readers will find the articles in this series to be of great value, with a high impact and average cited half-life of nine years.

The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. This great resource ranks high amongst scientific journals dealing with cell biology.

• Publishes only invited review articles on selected topics
• Authored by established and active cell and molecular biologists, drawn from international sources
• Offers a wide range of perspectives on specific subjects

The IRCMB series covers all fields of cell and molecular biology. IRCMB articles are addressed to a very wide public, ranging from undergraduate and graduate students to experienced scientists in a specific field