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International Review of Cell and Molecular Biology - 1st Edition - ISBN: 9780128124673, 9780128124680

International Review of Cell and Molecular Biology, Volume 330

1st Edition

Serial Editor: Lorenzo Galluzzi
Hardcover ISBN: 9780128124673
eBook ISBN: 9780128124680
Imprint: Academic Press
Published Date: 20th February 2017
Page Count: 352
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Table of Contents

Chapter One: New Insights Into the Roles of Retinoic Acid Signaling in Nervous System Development and the Establishment of Neurotransmitter Systems

  • Abstract
  • 1 Introduction
  • 2 Developmental Signaling
  • 3 Retinoids as Morphogens, Teratogens, and Drugs
  • 4 RA Signaling Pathway
  • 5 Major Functions of RA Signaling
  • 6 RA Signaling During Nervous System Development
  • 7 RA Signaling and the Establishment of Neurotransmitter Systems
  • 8 RA Signaling Outside Vertebrates: Evolutionary Considerations
  • 9 Concluding Remarks
  • Acknowledgments

Chapter Two: AMBRA1, a Novel BH3-Like Protein: New Insights Into the AMBRA1–BCL2-Family Proteins Relationship

  • Abstract
  • 1 Introduction
  • 2 AMBRA1 in Autophagy, Selective Autophagy, and Beyond
  • 3 Autophagy and Apoptosis Cross-Talk
  • 4 Autophagy Inhibition by the Oncogenic Function of BCL2
  • 5 BCL2–AMBRA1 Interaction as a Novel Therapeutic Target
  • 6 Conclusion
  • Acknowledgments

Chapter Three: Rationale for the Combination of Dendritic Cell-Based Vaccination Approaches With Chemotherapy Agents

  • Abstract
  • 1 Introduction
  • 2 Immunological Aspects of Anticancer Chemotherapy With Regards to DC Functions
  • 3 Clinical Trials of Combined DC-Based Immunotherapy and Chemotherapy Affecting DC Functions
  • 4 Conclusions
  • Acknowledgments

Chapter Four: Smac Mimetics to Therapeutically Target IAP Proteins in Cancer

  • Abstract
  • 1 Introduction
  • 2 IAP Proteins
  • 3 Mechanisms of Action of Smac Mimetics
  • 4 Smac Mimetics as Single Agents
  • 5 Smac Mimetic-Based Combination Therapies
  • 6 Conclusions
  • Acknowledgments

Chapter Five: Consequences of Keratin Phosphorylation for Cytoskeletal Organization and Epithelial Functions

  • Abstract
  • 1 Introduction
  • 2 Characteristics of Keratin Phosphorylation
  • 3 Regulation of Protein Binding to Keratins by Phosphorylation
  • 4 Role of Keratin Phosphorylation in Cell Physiology
  • 5 Disease Relevance of Keratin Phosphorylation
  • 6 Concluding Remarks: Significance of Keratin Phosphorylation
  • Acknowledgments

Chapter Six: Plastid Protein Targeting: Preprotein Recognition and Translocation

  • Abstract
  • 1 Introduction
  • 2 Origin of Plastids
  • 3 Plastid Protein Targeting Routes
  • 4 Regulation of Plastid Protein Import
  • 5 Concluding Remarks
  • Acknowledgments

Chapter Seven: Immunomodulatory Activity of VEGF in Cancer

  • Abstract
  • 1 Introduction
  • 2 The VEGF Family
  • 3 VEGF Receptors
  • 4 The VEGF-A/VEGFR Axis
  • 5 Antitumor Immunity
  • 6 Immunosuppressive Roles of VEGF
  • 7 Immunomodulatory Properties of Therapeutics Targeting VEGF
  • 8 Medical Applications
  • 9 Concluding Remarks
  • Acknowledgments


International Review of Cell and Molecular Biology (IRCMB), Volume 330 includes comprehensive and detailed reviews on the current advances in cell and molecular biology. The IRCMB series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of nine years. IRCMB ranks high amongst scientific journals dealing with cell biology.

Key Features

  • Includes comprehensive and detailed reviews on the current advances in cell and molecular biology
  • Publishes only invited review articles on selected topics
  • Authored by established and active cell and molecular biologists, drawn from international sources
  • Offers a wide range of perspectives on specific subjects


The IRCMB series covers all fields of cell and molecular biology. IRCMB articles are addressed to a very wide public, ranging from undergraduate and graduate students to experienced scientists in a specific field


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© Academic Press 2017
20th February 2017
Academic Press
Hardcover ISBN:
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About the Serial Editor

Lorenzo Galluzzi

Lorenzo Galluzzi

Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology. Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals: OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.

Affiliations and Expertise

Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USA