International Review of Cell and Molecular Biology - 1st Edition - ISBN: 9780128124673, 9780128124680

International Review of Cell and Molecular Biology, Volume 330

1st Edition

Serial Editors: Lorenzo Galluzzi
eBook ISBN: 9780128124680
Hardcover ISBN: 9780128124673
Imprint: Academic Press
Published Date: 20th February 2017
Page Count: 352
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Table of Contents

Chapter One: New Insights Into the Roles of Retinoic Acid Signaling in Nervous System Development and the Establishment of Neurotransmitter Systems

  • Abstract
  • 1 Introduction
  • 2 Developmental Signaling
  • 3 Retinoids as Morphogens, Teratogens, and Drugs
  • 4 RA Signaling Pathway
  • 5 Major Functions of RA Signaling
  • 6 RA Signaling During Nervous System Development
  • 7 RA Signaling and the Establishment of Neurotransmitter Systems
  • 8 RA Signaling Outside Vertebrates: Evolutionary Considerations
  • 9 Concluding Remarks
  • Acknowledgments

Chapter Two: AMBRA1, a Novel BH3-Like Protein: New Insights Into the AMBRA1–BCL2-Family Proteins Relationship

  • Abstract
  • 1 Introduction
  • 2 AMBRA1 in Autophagy, Selective Autophagy, and Beyond
  • 3 Autophagy and Apoptosis Cross-Talk
  • 4 Autophagy Inhibition by the Oncogenic Function of BCL2
  • 5 BCL2–AMBRA1 Interaction as a Novel Therapeutic Target
  • 6 Conclusion
  • Acknowledgments

Chapter Three: Rationale for the Combination of Dendritic Cell-Based Vaccination Approaches With Chemotherapy Agents

  • Abstract
  • 1 Introduction
  • 2 Immunological Aspects of Anticancer Chemotherapy With Regards to DC Functions
  • 3 Clinical Trials of Combined DC-Based Immunotherapy and Chemotherapy Affecting DC Functions
  • 4 Conclusions
  • Acknowledgments

Chapter Four: Smac Mimetics to Therapeutically Target IAP Proteins in Cancer

  • Abstract
  • 1 Introduction
  • 2 IAP Proteins
  • 3 Mechanisms of Action of Smac Mimetics
  • 4 Smac Mimetics as Single Agents
  • 5 Smac Mimetic-Based Combination Therapies
  • 6 Conclusions
  • Acknowledgments

Chapter Five: Consequences of Keratin Phosphorylation for Cytoskeletal Organization and Epithe


International Review of Cell and Molecular Biology (IRCMB), Volume 330 includes comprehensive and detailed reviews on the current advances in cell and molecular biology. The IRCMB series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of nine years. IRCMB ranks high amongst scientific journals dealing with cell biology.

Key Features

  • Includes comprehensive and detailed reviews on the current advances in cell and molecular biology
  • Publishes only invited review articles on selected topics
  • Authored by established and active cell and molecular biologists, drawn from international sources
  • Offers a wide range of perspectives on specific subjects


The IRCMB series covers all fields of cell and molecular biology. IRCMB articles are addressed to a very wide public, ranging from undergraduate and graduate students to experienced scientists in a specific field


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© Academic Press 2017
Academic Press
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Ratings and Reviews

About the Serial Editors

Lorenzo Galluzzi Serial Editor

Lorenzo Galluzzi received his Ph.D. in 2008 from the University of Paris Sud/Paris XI (France), and now works as a research manager in the laboratory of Guido Kroemer. He is particularly fascinated by several aspects of mitochondrial cell death, autophagy, cancer cell metabolism and tumour immunology. He has published more than 270 articles in peer-reviewed scientific journals, and is currently the 6th and youngest of the 30 most-cited European cell biologists (relative to the period 2007-2013).

Affiliations and Expertise

Department of Radiation Oncology, Weill Cornell Medical College, NY, USA