International Review of Cell and Molecular Biology

Chapter One: New Insights Into the Roles of Retinoic Acid Signaling in Nervous System Development and the Establishment of Neurotransmitter Systems

• Abstract
• 1 Introduction
• 2 Developmental Signaling
• 3 Retinoids as Morphogens, Teratogens, and Drugs
• 4 RA Signaling Pathway
• 5 Major Functions of RA Signaling
• 6 RA Signaling During Nervous System Development
• 7 RA Signaling and the Establishment of Neurotransmitter Systems
• 8 RA Signaling Outside Vertebrates: Evolutionary Considerations
• 9 Concluding Remarks
• Acknowledgments

Chapter Two: AMBRA1, a Novel BH3-Like Protein: New Insights Into the AMBRA1–BCL2-Family Proteins Relationship

• Abstract
• 1 Introduction
• 2 AMBRA1 in Autophagy, Selective Autophagy, and Beyond
• 3 Autophagy and Apoptosis Cross-Talk
• 4 Autophagy Inhibition by the Oncogenic Function of BCL2
• 5 BCL2–AMBRA1 Interaction as a Novel Therapeutic Target
• 6 Conclusion
• Acknowledgments

Chapter Three: Rationale for the Combination of Dendritic Cell-Based Vaccination Approaches With Chemotherapy Agents

• Abstract
• 1 Introduction
• 2 Immunological Aspects of Anticancer Chemotherapy With Regards to DC Functions
• 3 Clinical Trials of Combined DC-Based Immunotherapy and Chemotherapy Affecting DC Functions
• 4 Conclusions
• Acknowledgments

Chapter Four: Smac Mimetics to Therapeutically Target IAP Proteins in Cancer

• Abstract
• 1 Introduction
• 2 IAP Proteins
• 3 Mechanisms of Action of Smac Mimetics
• 4 Smac Mimetics as Single Agents
• 5 Smac Mimetic-Based Combination Therapies
• 6 Conclusions
• Acknowledgments

Chapter Five: Consequences of Keratin Phosphorylation for Cytoskeletal Organization and Epithelial Functions

• Abstract
• 1 Introduction
• 2 Characteristics of Keratin Phosphorylation
• 3 Regulation of Protein Binding to Keratins by Phosphorylation
• 4 Role of Keratin Phosphorylation in Cell Physiology
• 5 Disease Relevance of Keratin Phosphorylation
• 6 Concluding Remarks: Significance of Keratin Phosphorylation
• Acknowledgments

Chapter Six: Plastid Protein Targeting: Preprotein Recognition and Translocation

• Abstract
• 1 Introduction
• 2 Origin of Plastids
• 3 Plastid Protein Targeting Routes
• 4 Regulation of Plastid Protein Import
• 5 Concluding Remarks
• Acknowledgments

Chapter Seven: Immunomodulatory Activity of VEGF in Cancer

• Abstract
• 1 Introduction
• 2 The VEGF Family
• 3 VEGF Receptors
• 4 The VEGF-A/VEGFR Axis
• 5 Antitumor Immunity
• 6 Immunosuppressive Roles of VEGF
• 7 Immunomodulatory Properties of Therapeutics Targeting VEGF
• 8 Medical Applications
• 9 Concluding Remarks
• Acknowledgments