Interleukins - 1st Edition - ISBN: 9780127098746, 9780080466101

Interleukins, Volume 74

1st Edition

Editor-in-Chiefs: Gerald Litwack
eBook ISBN: 9780080466101
Hardcover ISBN: 9780127098746
Imprint: Academic Press
Published Date: 26th September 2006
Page Count: 600
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Table of Contents

IL-3, IL-5 and GM-CSF Signalling: Crystal Structure of the Human Beta-common Receptor Crystal structures and inhibitors of proteins involved in IL-2 release and T-cell signalling Structural Studies of the Interleukin-19 Subfamily of Cytokines
Interleukin-22 and its Crystal Structure Control of Interleukin-2 gene transcription: A paradigm for inducible, tissue¡Vspecific gene expression Transcription Factors Mediating Interleukin-3 Survival Signals Interleukins and Stat Signaling The newest Interleukins: recent additions to the ever growing cytokine family The Interleukin-1 Receptor Family The IL-17 Cytokine Family NFƒÛB and Cytokines IƒÛB-ƒê: An Inducible Regulator of Nuclear Factor-ƒÛB The Inhibitory Effects of Interleukin-1 on Growth Hormone Action during Catabolic Illness The Role of the Interleukin-6/Gp130 Signaling Pathway in Bone Metabolism Regulation of Osteoclast Differentiation and Function by Interleukin 1 The role of IL-1 and IL-1 Ra in Joint Inflammation and Cartilage Degradation Cytokines in Type 2 Diabetes Release of Interleukins and other Inflammatory Cytokines by Human Adipose Tissue is Enhanced in Obesity and Primarily due to the Non-Fat Cells Role of Interleukin-13 in Cancer, Pulmonary Fibrosis and other TH2 Type Diseases Interleukins, Inflammation and Mechanisms of Alzheimer¡¦s Disease Interleukin-2: From T Cell Growth and Homeostasis to Immune Reconstitution of HIV Patients


First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.


Endocrinologists, biochemists, researchers, professors, and graduate students studying the molecular and cellular biology of vitamins, hormones, and related factors and co-factors


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© Academic Press 2006
Academic Press
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About the Editor-in-Chiefs

Gerald Litwack Editor-in-Chief

Following a liberal arts education with a major in chemistry and biology at Hobart College, Gerald (Gerry) Litwack earned M.S. and PhD degrees in biochemistry from the University of Wisconsin, Madison where he served as a Lecturer in Enzymology before starting a postdoctoral fellowship from the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. His first academic position was assistant professor of biochemistry at Rutgers University where he started his work on hormone action for six years. During this period, he did a sabbatical at the University of California, Berkeley, where he concentrated on rapid enzyme kinetics. In 1960 he accepted an offer of an associate professorship at the University of Pennsylvania Graduate School of Medicine. In 1964, he was invited to be full professor of biochemistry at The Fels Institute for Cancer Research and Molecular Biology at Temple Medical School, simultaneously with a Career Development Award from the NIH, where he later was named Deputy Director of the Institute and the Laura H. Carnell Professor in biochemistry. Subsequently, he was given the Faculty Research Award. He co-discovered ligandin, later found to be in the family of glutathione S-transferases, enzymes that protect the body from carcinogens. In 1991, he moved to the Jefferson Medical College at Thomas Jefferson University as Professor of Biochemistry, Chair of the Department of Pharmacology and Deputy Director of the Kimmel Cancer Research Institute. Later, he became chair of the combined Department of Biochemistry and Molecular Pharmacology and concurrently held the position of Vice Dean for Research. In 2003, he moved to Los Angeles and from 2004-2006 was a Visiting Scholar at the University of California, Los Angeles, in the Department of Biological Chemistry of the Geffen School of Medicine and, in this period, wrote “Human Biochemistry and Disease” a volume of 1254 pages. In 2007, he moved to Scranton, Pennsylvania, as Founding Chair of Basic Sciences and Acting Associate Dean for Research to start a new medical school, The Commonwealth Medical College. Having completing his mission in 2010, he moved to The Institute for Regenerative Medicine, Texas A & M Health Science Center, as Professor of Biochemistry and Associate Director. Currently, he is retired and lives in North Hollywood, California, where he continues as an author and as Series Editor of Vitamins and Hormones. He is involved in writing another textbook and has written a first novel, “One-Eighty”.

Affiliations and Expertise

Toluca Lake, North Hollywood, California, USA