Interleukin 3

Interleukin 3

The Panspecific Hemopoietin

1st Edition - February 28, 1988

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  • Editor: John W. Schrader
  • eBook ISBN: 9781483268163

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Interleukin 3: The Panspecific Hemopoietin contains contributions from immunologists, hematologists, protein chemists, and molecular biologists whose efforts have defined the biology and molecular nature of interleukin 3 (IL-3) in less than a decade. The articles represent personal perspectives rather than exhaustive reviews. They are arranged in alphabetical order rather than thematically because many of the individual articles cover multiple aspects of the molecule. These articles cover topics such as the potential role of IL-3 in the pathology of allergic and inflammatory disease and the role of IL-3 in the genesis of certain myeloid leukemias. A number of articles also highlight an important technical point, namely, that many of the various assays often used for IL-3 are not specific. One article indicates that the ""histamine-producing cell-stimulating factor"" activity can be mediated not only by IL-3 but also by granulocyte-macrophage colony-stimulating factor. Another deals with the lack of specificity of assays based on the induction of 20α-SDH or factor-dependent cell lines.

Table of Contents

  • Preface

    Molecular Structure and Biological Activities of P Cell-Stimulating Factor (Interieukin 3)

    I. Introduction

    II. History and Nomenclature

    III. Cellular Sources and Assays

    IV. Biological Activities

    V. Characterization, Purification, and Structure

    VI. Structure-Function Studies Approached by Peptide Synthesis

    VII. Summary


    Histamine-Producing Cell-Stimulating Factor (HCSF) and Interieukin 3 (IL-3): Their Effects on Histidine and Ornithine Decarboxylases

    I. Introduction

    II. Evidence for a Lymphokine Increasing Histamine Synthesis: Histamine-Producing Cell-Stimulating Factor

    III. Interieukin 3 (IL-3) and Histamine-Producing Cell-Stimulating Factor

    IV. Interieukin 3 and Arginine Metabolism in Hemopoietic Cells

    V. Summary

    VI. Addendum


    IL-3 and the Development of Cultured (Mucosal) Mast Cells in the Rat

    I. Introduction

    II. Mast Cells In Vivo and In Vitro

    III. IL-3-Like Activity in the Rat

    IV. The Target Cells Responding to IL-3

    V. Maturation of IL-3-Dependent Cell Types

    VI. Conclusions and Speculations: IL-3 and MMC in Disease

    VII. Addendum


    Molecular Biology of Interleukin 3: A Multilineage Hemopoietic Growth Regulator

    I. Introduction

    II. Biological Properties of Interleukin 3

    III. Assays for Interleukin 3

    IV. Isolation of cDNA Clones for Murine Interleukin 3

    V. Cloning of the Gene for Murine Interleukin 3

    VI. Expression from Recombinant DNA Constructs

    VII. Cloning of the Rat and Human Interleukin 3 Genes

    VIII. Interleukin 3 and Leukemia

    IX. Monoclonal Antibodies to Interleukin 3

    X. Conclusion


    Immunological Regulation of Hematopoietic Stem Cell Function by Interleukin 3 and Its Role in Leukemogenesis

    I. Introduction

    II. Sequence of IL-3-Supported Differentiation In Vitro

    III. Relationship of IL-3-Regulated Growth and Differentiation to Leukemogenesis

    IV. Mechanisms in IL-3-Regulated Differentiation

    V. Mechanisms in IL-3-Regulated Growth

    VI. Conclusions and Speculations


    The Expression and Characterization of Recombinant Mouse IL-3

    I. Introduction

    II. Expression of IL-3 in Mammalian Cells

    III. Expression of IL-3 in Escherichia Coli

    IV. Expression of IL-3 in Yeast

    V. Conclusion


    The Multipotential Colony-Stimulating Factor, Multi-CSF (IL-3)

    I. Terminology

    II. Review of Work on Multi-CSF in This Laboratory

    III. Biochemical Nature and Molecular Biology of Multi-CSF

    IV. Tissue Sources of Multi-CSF

    V. Membrane Receptors for Multi-CSF

    VI. Biological Actions in Vitro of Multi-CSF

    VII. In Vivo Fate of Multi-CSF

    VIII. In Vivo Effects of Injected Bacterially Synthesized Multi-CSF

    IX. Does Multi-CSF Play a Special Role in Leukemogenesis?

    X. Is There a Human Analog of Murine Multi-CSF?

    XI. Summary


    Interieukin 3: An Overview

    I. Introduction

    II. Cellular Origins of Interieukin 3

    III. Biochemical and Molecular Aspects

    IV. Interleukin 3 Receptor Characterization

    V. Interleukin 3 in Myeloid Differentiation

    VI. Interleukin 3 Action in Erythropoiesis

    VII. Interleukin 3 Action in Megakaryocytopoiesis

    VIII. Interleukin 3: A Mast Cell and Basophil Growth Factor

    IX. Interleukin 3 and Natural Cytotoxic Cells

    X. The Role of Interleukin 3 in Β Cell Development

    XI. Interleukin 3 Action on Pluripotential Stem Cells

    XII. Interleukin 3 and the Proliferation of Factor-Dependent Cell Lines

    XIII. In Vivo Action of Interleukin 3

    XIV. Interleukin 3 and Murine Myeloid Leukemia—Autocrine Regulation

    XV. Conclusion


    The Panspecific Hemopoietin Interleukin 3: Physiology and Pathology

    I. Introduction

    II. Production of IL-3 In Vivo

    III. Clearance of IL-3 from the Blood

    IV. Action of IL-3 In Vivo

    V. Mechanism of Action of IL-3

    VI. Pathological Role of IL-3

    VII. Role of IL-3 in Neoplasia

    VIII. Summary


    Mast Cell Subclasses and Their Growth Dependence in Mice, Rats, and Humans

    I. Introduction

    II. The Mouse Cultured IL-3-Dependent Mast Cell

    III. The Rat Cultured Τ Cell Factor-Dependent Mast Cell

    IV. Mucosal Mast Cells

    V. The Rat Basophilic Leukemic Cell: Mucosal Mast Cell Phenotype

    VI. Maintenance of Rat Connective Tissue Mast Cells in Coculture

    VII. Cultured Human Τ Cell Factor-Dependent Mast Cells or Basophils

    VIII. Human Mast Cell Subclasses In Vivo

    IX. Basophils and Eosinophils

    X. Summary: The Relationship of Connective Tissue Mast Cells, Mucosal Mast Cells, Basophils, and Eosinophils


    Human Growth Factors for Metachromatically Staining Cells

    I. Introduction

    II. A Human Basophil-Like Cell-Promoting Activity (BaPA)

    III. A Growth Factor for Human Mast Cell-Like Cells: IL-3-Like Activity

    IV. Biochemical Characteristics of Human IL-3-Like Activity

    V. Summary and Perspectives


    Note Added in Proof

    The Mode of Action of Interieukin 3 in Promoting Survival, Proliferation, and Differentiation of Hemopoietic Progenitor Cells

    I. Introduction

    II. Long-Term Marrow Cultures and the Development of Interieukin 3-Dependent Cell Lines

    III. Purification of Interieukin 3 Using FDC-P Cell Lines

    IV. Preparation of Interieukin 3-Dependent Multipotent Stem Cell Lines

    V. The Mode of Action of Interieukin 3 in Promoting Survival and Proliferation of Hemopoietic Cells

    VI. The Mediation of Transmembrane Signaling Events by Interleukin 3

    VII. Intracellular Mechanisms Governing Stem Cell Differentiation

    VIII. Possible Roles of Interleukin 3 in Long-Term Marrow Cultures and In Vivo


    Molecular Cloning of a Primate cDNA and the Human Gene for Interleukin 3

    I. Introduction

    II. Molecular Cloning and Expression of the Primate IL-3 cDNA

    III. The Human IL-3 Gene

    IV. Conclusions


    Isolation and Characterization of the Mouse Interleukin 3 Gene and Its Expression in Activated T Cells

    I. Introduction

    II. Isolation of cDNA Clones Encoding Interleukin 3

    III. Structure of the IL-3 Gene

    IV. Expression of IL-3 mRNA

    V. Constitutive Expression of the IL-3 Gene

    VI. Transcription of the IL-3 Gene In Vitro



Product details

  • No. of pages: 444
  • Language: English
  • Copyright: © Academic Press 1988
  • Published: February 28, 1988
  • Imprint: Academic Press
  • eBook ISBN: 9781483268163

About the Editor

John W. Schrader

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