Interleukin 3

Preface

Molecular Structure and Biological Activities of P Cell-Stimulating Factor (Interieukin 3)

I. Introduction

II. History and Nomenclature

III. Cellular Sources and Assays

IV. Biological Activities

V. Characterization, Purification, and Structure

VI. Structure-Function Studies Approached by Peptide Synthesis

VII. Summary

References

Histamine-Producing Cell-Stimulating Factor (HCSF) and Interieukin 3 (IL-3): Their Effects on Histidine and Ornithine Decarboxylases

I. Introduction

II. Evidence for a Lymphokine Increasing Histamine Synthesis: Histamine-Producing Cell-Stimulating Factor

III. Interieukin 3 (IL-3) and Histamine-Producing Cell-Stimulating Factor

IV. Interieukin 3 and Arginine Metabolism in Hemopoietic Cells

V. Summary

VI. Addendum

References

IL-3 and the Development of Cultured (Mucosal) Mast Cells in the Rat

I. Introduction

II. Mast Cells In Vivo and In Vitro

III. IL-3-Like Activity in the Rat

IV. The Target Cells Responding to IL-3

V. Maturation of IL-3-Dependent Cell Types

VI. Conclusions and Speculations: IL-3 and MMC in Disease

VII. Addendum

References

Molecular Biology of Interleukin 3: A Multilineage Hemopoietic Growth Regulator

I. Introduction

II. Biological Properties of Interleukin 3

III. Assays for Interleukin 3

IV. Isolation of cDNA Clones for Murine Interleukin 3

V. Cloning of the Gene for Murine Interleukin 3

VI. Expression from Recombinant DNA Constructs

VII. Cloning of the Rat and Human Interleukin 3 Genes

VIII. Interleukin 3 and Leukemia

IX. Monoclonal Antibodies to Interleukin 3

X. Conclusion

References

Immunological Regulation of Hematopoietic Stem Cell Function by Interleukin 3 and Its Role in Leukemogenesis

I. Introduction

II. Sequence of IL-3-Supported Differentiation In Vitro

III. Relationship of IL-3-Regulated Growth and Differentiation to Leukemogenesis

IV. Mechanisms in IL-3-Regulated Differentiation

V. Mechanisms in IL-3-Regulated Growth

VI. Conclusions and Speculations

References

The Expression and Characterization of Recombinant Mouse IL-3

I. Introduction

II. Expression of IL-3 in Mammalian Cells

III. Expression of IL-3 in Escherichia Coli

IV. Expression of IL-3 in Yeast

V. Conclusion

References

The Multipotential Colony-Stimulating Factor, Multi-CSF (IL-3)

I. Terminology

II. Review of Work on Multi-CSF in This Laboratory

III. Biochemical Nature and Molecular Biology of Multi-CSF

IV. Tissue Sources of Multi-CSF

V. Membrane Receptors for Multi-CSF

VI. Biological Actions in Vitro of Multi-CSF

VII. In Vivo Fate of Multi-CSF

VIII. In Vivo Effects of Injected Bacterially Synthesized Multi-CSF

IX. Does Multi-CSF Play a Special Role in Leukemogenesis?

X. Is There a Human Analog of Murine Multi-CSF?

XI. Summary

References

Interieukin 3: An Overview

I. Introduction

II. Cellular Origins of Interieukin 3

III. Biochemical and Molecular Aspects

IV. Interleukin 3 Receptor Characterization

V. Interleukin 3 in Myeloid Differentiation

VI. Interleukin 3 Action in Erythropoiesis

VII. Interleukin 3 Action in Megakaryocytopoiesis

VIII. Interleukin 3: A Mast Cell and Basophil Growth Factor

IX. Interleukin 3 and Natural Cytotoxic Cells

X. The Role of Interleukin 3 in Β Cell Development

XI. Interleukin 3 Action on Pluripotential Stem Cells

XII. Interleukin 3 and the Proliferation of Factor-Dependent Cell Lines

XIII. In Vivo Action of Interleukin 3

XIV. Interleukin 3 and Murine Myeloid Leukemia—Autocrine Regulation

XV. Conclusion

References

The Panspecific Hemopoietin Interleukin 3: Physiology and Pathology

I. Introduction

II. Production of IL-3 In Vivo

III. Clearance of IL-3 from the Blood

IV. Action of IL-3 In Vivo

V. Mechanism of Action of IL-3

VI. Pathological Role of IL-3

VII. Role of IL-3 in Neoplasia

VIII. Summary

References

Mast Cell Subclasses and Their Growth Dependence in Mice, Rats, and Humans

I. Introduction

II. The Mouse Cultured IL-3-Dependent Mast Cell

III. The Rat Cultured Τ Cell Factor-Dependent Mast Cell

IV. Mucosal Mast Cells

V. The Rat Basophilic Leukemic Cell: Mucosal Mast Cell Phenotype

VI. Maintenance of Rat Connective Tissue Mast Cells in Coculture

VII. Cultured Human Τ Cell Factor-Dependent Mast Cells or Basophils

VIII. Human Mast Cell Subclasses In Vivo

IX. Basophils and Eosinophils

X. Summary: The Relationship of Connective Tissue Mast Cells, Mucosal Mast Cells, Basophils, and Eosinophils

References

Human Growth Factors for Metachromatically Staining Cells

I. Introduction

II. A Human Basophil-Like Cell-Promoting Activity (BaPA)

III. A Growth Factor for Human Mast Cell-Like Cells: IL-3-Like Activity

IV. Biochemical Characteristics of Human IL-3-Like Activity

V. Summary and Perspectives

References

Note Added in Proof

The Mode of Action of Interieukin 3 in Promoting Survival, Proliferation, and Differentiation of Hemopoietic Progenitor Cells

I. Introduction

II. Long-Term Marrow Cultures and the Development of Interieukin 3-Dependent Cell Lines

III. Purification of Interieukin 3 Using FDC-P Cell Lines

IV. Preparation of Interieukin 3-Dependent Multipotent Stem Cell Lines

V. The Mode of Action of Interieukin 3 in Promoting Survival and Proliferation of Hemopoietic Cells

VI. The Mediation of Transmembrane Signaling Events by Interleukin 3

VII. Intracellular Mechanisms Governing Stem Cell Differentiation

VIII. Possible Roles of Interleukin 3 in Long-Term Marrow Cultures and In Vivo

References

Molecular Cloning of a Primate cDNA and the Human Gene for Interleukin 3

I. Introduction

II. Molecular Cloning and Expression of the Primate IL-3 cDNA

III. The Human IL-3 Gene

IV. Conclusions

References

Isolation and Characterization of the Mouse Interleukin 3 Gene and Its Expression in Activated T Cells

I. Introduction

II. Isolation of cDNA Clones Encoding Interleukin 3

III. Structure of the IL-3 Gene

IV. Expression of IL-3 mRNA

V. Constitutive Expression of the IL-3 Gene

VI. Transcription of the IL-3 Gene In Vitro

References

Index