1st Edition - January 1, 1982

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  • Editor: Thomas Merigan
  • eBook ISBN: 9780323147903

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Interferons documents the proceedings of a major international conference on Chemistry and Biology of Interferons: Relationship to Therapeutics held at Squaw Valley, California, in March 1982. The meeting was one of the 1982 UCLA Symposia on Molecular and Cellular Biology organized through the Molecular Biology Institute of the University of California at Los Angeles. The book is organized into four parts. Part I presents papers on recombinant DNA production of interferon. It includes studies on the synthesis of human immune interferon in E. coli and monkey cells; the expression of human β interferon gene in heterologous cells; and the molecular activities of recombinant and hybrid leukocyte interferons. Part II deals with the biology of interferons, covering topics such as interferon production control process; the effect of interferon on cellular enzymes; and human amniotic interferon. Part III examines the factors relevant to clinical application of interferons, including structure-function studies with human interferon-gamma and on human alpha interferon. Part IV presents clinical studies of interferon, such as interferon α trials in human tumor diseases and interferon in renal transplant recipients.

Table of Contents

  • Contributors


    I. Recombinant DNA Production of Interferon

    1. Plasmid-Directed Synthesis of Human Immune Interferon in E. coli and Monkey Cells

    2. Expression of the Cloned Genes for Human Interferon β1 in E. coli and Cultured Mouse Cells

    3. Regulation of the Human Interferon β Gene in Mouse L Cell Clones in Human Cells

    4. Expression of Human β Interferon Gene in Heterologous Cells

    5. Interferon Action: Cloning of cDNA Segments Complementary to Messenger RNAs Induced by Interferons

    6. The Processing of Human Interferon β-mRNA

    6A. Molecular Activities of Recombinant and Hybrid Leukocyte Interferons

    II. Biology of Interferons

    7. Control Processes in Interferon Production

    8. Effect of Interferon on Cellular Enzymes

    9. Double-Stranded RNA and 2' ,5'-Oligoadenylates: Companions in Interferon Action?

    10. The 2-5A System and Interferon Action

    11. Interferon Modulates Cell Structure and Function

    12. Interferon Inhibits Bovine Papillomavirus Transformation of Mouse Cells and Induces Reversion of Established Transformants

    13. Immunodeficiencies, Aneuploidy, and Interferon

    14. Interferon and Human Autoimmune Diseases and Lymphoproliferative Disorders

    15. Interferon in Systemic Lupus Erythematosus

    16. Alpha Interferon and Antibody to Alpha Interferon in Systemic Lupus Erythematosus

    17. Study of Human Amniotic Interferon

    18. The Detection of Interferon Activity in Human Amniotic Fluid

    19. The Assay of 2-5A Synthetase as an Indicator of Interferon Activity and Virus Infection in Vivo

    20. Interactions between Interferon and Cells of the Immune System

    21. Induction of Immune Interferon from Human Lymphocytes by Influenza-Infected Stimulator Cells

    22. Interferon and NK Cells

    22A. Structure and Expression of Human Alpha-Interferon Genes

    III. Factors Relevant to Clinical Application of Interferon

    23. In Remembrance of Lowell Glasgow, M.D.

    24. Interferons and Drug Metabolism

    25. Pharmacological Comparison of Two Hybrid Recombinant DNA-Derived Human Leukocyte Interferons

    26. Structure-Function Studies with Human Interferon-Gamma

    27. Structure-Function Studies on Human Alpha Interferon

    28. Modulation of NK and Monocyte Activity in Advanced Cancer Patients Receiving Interferon

    29. The Toxicity of Human Interferons in Nonhuman Primates

    30. Alpha-Interferon in Simian and Human Varicella

    IV. Clinical Studies with Interferon

    31. Interferon a Trials in Human Tumor Diseases

    32 Phase I Evaluation of Human Interferon a Following Intraarterial, Intratumor Infusion—Pharmacokinetic and Immunologic Analysis

    33. Interferon in Renal Transplant Recipients

    34. Clinical Trials and Pilot Studies with Beta-Interferon in Germany

    35. Phase I Trials of Recombinant and Nonrecombinant Alpha Interferons in Cancer Patients

    36 Interferon-Induced Proteins: Biological Functions and Clinical Applications

    37. Effect of Human Interferon-β in the Treatment of Malignant Brain Tumors


Product details

  • No. of pages: 504
  • Language: English
  • Copyright: © Academic Press 1982
  • Published: January 1, 1982
  • Imprint: Academic Press
  • eBook ISBN: 9780323147903

About the Editor

Thomas Merigan

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