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Interferons - 1st Edition - ISBN: 9780124912205, 9780323147903


1st Edition

Editor: Thomas Merigan
eBook ISBN: 9780323147903
Imprint: Academic Press
Published Date: 1st January 1982
Page Count: 504
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Interferons documents the proceedings of a major international conference on Chemistry and Biology of Interferons: Relationship to Therapeutics held at Squaw Valley, California, in March 1982. The meeting was one of the 1982 UCLA Symposia on Molecular and Cellular Biology organized through the Molecular Biology Institute of the University of California at Los Angeles. The book is organized into four parts. Part I presents papers on recombinant DNA production of interferon. It includes studies on the synthesis of human immune interferon in E. coli and monkey cells; the expression of human β interferon gene in heterologous cells; and the molecular activities of recombinant and hybrid leukocyte interferons. Part II deals with the biology of interferons, covering topics such as interferon production control process; the effect of interferon on cellular enzymes; and human amniotic interferon. Part III examines the factors relevant to clinical application of interferons, including structure-function studies with human interferon-gamma and on human alpha interferon. Part IV presents clinical studies of interferon, such as interferon α trials in human tumor diseases and interferon in renal transplant recipients.

Table of Contents



I. Recombinant DNA Production of Interferon

1. Plasmid-Directed Synthesis of Human Immune Interferon in E. coli and Monkey Cells

2. Expression of the Cloned Genes for Human Interferon β1 in E. coli and Cultured Mouse Cells

3. Regulation of the Human Interferon β Gene in Mouse L Cell Clones in Human Cells

4. Expression of Human β Interferon Gene in Heterologous Cells

5. Interferon Action: Cloning of cDNA Segments Complementary to Messenger RNAs Induced by Interferons

6. The Processing of Human Interferon β-mRNA

6A. Molecular Activities of Recombinant and Hybrid Leukocyte Interferons

II. Biology of Interferons

7. Control Processes in Interferon Production

8. Effect of Interferon on Cellular Enzymes

9. Double-Stranded RNA and 2' ,5'-Oligoadenylates: Companions in Interferon Action?

10. The 2-5A System and Interferon Action

11. Interferon Modulates Cell Structure and Function

12. Interferon Inhibits Bovine Papillomavirus Transformation of Mouse Cells and Induces Reversion of Established Transformants

13. Immunodeficiencies, Aneuploidy, and Interferon

14. Interferon and Human Autoimmune Diseases and Lymphoproliferative Disorders

15. Interferon in Systemic Lupus Erythematosus

16. Alpha Interferon and Antibody to Alpha Interferon in Systemic Lupus Erythematosus

17. Study of Human Amniotic Interferon

18. The Detection of Interferon Activity in Human Amniotic Fluid

19. The Assay of 2-5A Synthetase as an Indicator of Interferon Activity and Virus Infection in Vivo

20. Interactions between Interferon and Cells of the Immune System

21. Induction of Immune Interferon from Human Lymphocytes by Influenza-Infected Stimulator Cells

22. Interferon and NK Cells

22A. Structure and Expression of Human Alpha-Interferon Genes

III. Factors Relevant to Clinical Application of Interferon

23. In Remembrance of Lowell Glasgow, M.D.

24. Interferons and Drug Metabolism

25. Pharmacological Comparison of Two Hybrid Recombinant DNA-Derived Human Leukocyte Interferons

26. Structure-Function Studies with Human Interferon-Gamma

27. Structure-Function Studies on Human Alpha Interferon

28. Modulation of NK and Monocyte Activity in Advanced Cancer Patients Receiving Interferon

29. The Toxicity of Human Interferons in Nonhuman Primates

30. Alpha-Interferon in Simian and Human Varicella

IV. Clinical Studies with Interferon

31. Interferon a Trials in Human Tumor Diseases

32 Phase I Evaluation of Human Interferon a Following Intraarterial, Intratumor Infusion—Pharmacokinetic and Immunologic Analysis

33. Interferon in Renal Transplant Recipients

34. Clinical Trials and Pilot Studies with Beta-Interferon in Germany

35. Phase I Trials of Recombinant and Nonrecombinant Alpha Interferons in Cancer Patients

36 Interferon-Induced Proteins: Biological Functions and Clinical Applications

37. Effect of Human Interferon-β in the Treatment of Malignant Brain Tumors



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© Academic Press 1982
1st January 1982
Academic Press
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About the Editor

Thomas Merigan

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