Interferons A Primer - 1st Edition - ISBN: 9780122682803, 9780323160858

Interferons A Primer

1st Edition

Authors: Robert Friedman
eBook ISBN: 9780323160858
Imprint: Academic Press
Published Date: 28th January 1981
Page Count: 164
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Interferons: A Primer covers general information on interferon, including analysis, purification, production, properties, mechanism of action, and clinical uses. Organized into 10 chapters, the book starts with a short history of interferon’s discovery by Isaacs and Lindenmann, followed by topics on assays for interferon, such as factors affecting interferon assays and rapid biological assay. Chapters 3 to 6 discuss the purification, properties, production, antiviral action, and other functions of interferon. Chapters 7 and 8 examine the recovery from viral infection and clinical uses of interferon, with emphasis on treatment of human cancer. The concluding chapters focus on the application of interferon studies on two revolutionizing fields of biology, namely, the cloning of animal genes in microorganisms and the production of monoclonal antibodies. This book is intended for students, scientists, physicians, or educated laypersons who wish to know something about interferons, but do not plan carrying out research in this area.

Table of Contents


1 Introduction


2 Assays for Interferon

Factors Affecting Interferon Assays

Specific Assays for Interferons and Interferon Standards

Details of a Rapid Biological Assay for Interferons


3 Purification and Properties of Interferons

Purification of Mouse and Human Interferons

Properties of Interferons


4 Production of Interferons

Interferon Inducers

Mechanisms of Interferon Production


5 Mechanisms of Antiviral Action

The Structure of Viruses

Virus Replication

Virus Effects on Cells

The Antiviral State

Virus Replication in Interferon-Treated Cells

Restrictions of Interferon Action


6 Other Actions of Interferons

Effects on the Immune System

Effects on Cell Growth and Differentiation

Effects on Intracellular Enzymes and Other Cell-Produced Substances

Cell Surface Alteration


7 Interferons and Recovery from Viral Infections

Evidence That Interferons Are Active Factors in the Recovery from Primary Virus Infections

Interactions between Interferons and Other Natural Antiviral Mechanisms

"Interferons Are a Good Thing, But Too Much of a Good Thing Can Be a Bad Thing"


8 Clinical Uses of Interferons

Pharmacology of Interferons in Humans

Interferon Preparations Available for Use in Humans

Clinical Uses of Human Interferons

Treatment of Human Cancer with Interferon


9 The Future of Interferons


10 The Future Is Now




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© Academic Press 1981
Academic Press
eBook ISBN:

About the Author

Robert Friedman

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