Intercellular Signaling in Development and Disease - 1st Edition - ISBN: 9780123822154, 9780123822161

Intercellular Signaling in Development and Disease

1st Edition

Cell Signaling Collection

Editors: Edward A. Dennis Ralph Bradshaw
eBook ISBN: 9780123822161
Paperback ISBN: 9780123822154
Imprint: Academic Press
Published Date: 5th April 2011
Page Count: 540
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Required reading for anyone involved in cell signaling research with articles written and edited by experts in the field. This title covers disease states such as lymphoid leukemia, breast cancer, pulmonary fibrosis, systemic sclerosis, andinflammatory bowel disease, along with up-to-date research on signaling systems and mutations in
transcription factors that provide new targets for treating disease.

Key Features

  • Articles written and edited by experts in the field
  • Thematic volume covering disease states such as lymphoid leukemia, breast cancer, pulmonary fibrosis, systemic sclerosis, and inflammatory bowel disease
  • Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease
  • Readership

    Professionals, researchers and graduate students in molecular biology, biochemistry, cell biology, biomedicine, structural biology, systems biology, and genetics.

    Table of Contents

    The fourth volume includes chapters 294 to 340

    Signaling From Intracellular Compartments

    294 . Protein Quality Control in the Endoplasmic Reticulum

    295 . Quality Control and Quality Assurance in the Mitochondrion

    296 . Protein Quality Control in Peroxisomes: Ubiquitination of the Peroxisomal Targeting Signal Receptors

    297 . Mitochondrial Dynamics: Fusion and Division

    298 . The SREBP Pathway: Gene Regulation through Sterol Sensing and Gated Protein Trafficking

    299 . Regulating Endoplasmic Reticulum Function through the Unfolded Protein Response

    300 . Signaling Pathways from Mitochondria to the Cytoplasm and Nucleus

    301 . Apoptosis Signaling: A Means to an End

    302 . Regulation of Cell Cycle Progression

    303 . Signaling During Organelle Division and Inheritance: Peroxisomes

    304 . Signaling at the Nuclear Envelope

    305 . Bidirectional Crosstalk between Actin Dynamics and Endocytosis

    306 . Signaling in Autophagy Related Pathways

    Cell -Cell and Cell-Matrix Interaction

    307 . Overview of Cell – Cell and Cell – Matrix Interactions

    308 . Interactive Signaling Pathways in the Vasculature

    309 . Signaling Pathways Involved in Cardiogenesis

    310 . Regulatory Signaling in Pancreatic Organogenesis: Implications for Aberrant Signaling in Pancreatic Cancer

    311 . Trophic Effects of Gut Hormones in the Gastrointestinal Tract

    312 . The Neurotrophin Factors

    313 . Cell to Cell and Cell-Matrix Interactions in Bone

    314 . Cell-Cell Signaling in the Testis and Ovary

    315 . Signal Transduction in T Lymphocytes

    316 . Signal Transduction via the B Cell Antigen Receptor: A Crucial Regulator of B Cell Biology

    317 . Signaling Pathways in the Normal and Neoplastic Breast

    318 . Kidney

    319 . Cytokines and Cytokine Receptors Regulating Cell Survival, Proliferation, and Differentiation in Hematopoiesis

    320 . Signaling Pathways Regulating Growth and Differentiation of Adult Stem Cells

    321 . In Vivo Imaging of Cellular Network Signaling

    DISEASE PATHOPHYSIOLOGY: Translational Implications

    322 . The Roles of Ras Family Small GTPases in Breast Cancer

    323 . Translational Implications of Stromal–Epithelial Interactions in Prostate Cancer and the Potential Role of Prostate Cancer Stem/Progenitor Cells

    324 . Aberrant Signaling Pathways in Pancreatic Cancer: Opportunities for Targeted Therapeutics

    325 . The Evolution and Maintenance of the Multiple Myeloma Cell Clone within the Liquid Bone Marrow Compartment: Therapeutic Implications

    326 . The Pathophysiologic Role of the Bone Marrow Environment and its Niches in Multiple Myeloma

    327 . Signaling Targets in Myeloid Leukemias

    328 . Signaling Targets in Lymphoid Leukemias

    329 . Targeting Ras for Anticancer Drug Discovery

    330 . Targeting EWS/FLI1 Driven Signaling Pathways as Therapy for Tumors of the Ewing’s Sarcoma Family

    331 . IRS-Protein Scaffolds and Insulin/IGF Action in Central and Peripheral Tissues

    332 . Adipokine Signaling: Implications for Obesity

    333 . Angiogenesis Signaling Pathways as Targets in Cancer Therapy

    334 . CXC Chemokine Signaling in Interstitial Lung Diseases

    335 . Systemic Sclerosis

    336 . Signal Transduction in Rheumatoid Arthritis and Systemic Lupus Erythematosus

    337 . Translational Concepts in Vasculitis

    338 . Advances in Understanding the Pathogenesis of Infl ammatory Bowel Disease

    339 . Translational Implications of Proteomics

    340 . Translational Implications of microRNAs in Clinical Diagnostics and Therapeutics


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    © Academic Press 2011
    Academic Press
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    About the Editor

    Edward A. Dennis

    Edward A. Dennis is Distinguished Professor and former Chair of the Department of Chemistry and Biochemistry and Professor in the Department of Pharmacology in the School of Medicine at the University of California, San Diego. He is also Editor-in-Chief of the Journal of Lipid Research.

    Affiliations and Expertise

    Department of Chemistry and Biochemistry and Department of Pharmacology in the School of Medicine at the University of California, San Diego

    Ralph Bradshaw

    Ralph Bradshaw

    Ralph A. Bradshaw is Professor Emeritus in the Department of Physiology and biophysics at the University of California, Irvine. Prior to that he was on the faculty of the Department of Biological Chemistry, Washington University School of Medicine in St. Louis, MO and was Professor and Chair of the Department of Biological Chemistry at the University of California, Irvine. From 2006 to 2015, he was a member of the Mass Spectrometry Facility and Professor of Pharmaceutical Chemistry at the University of California, San Francisco. He holds degrees from Colby College and Duke University and was a post-doctoral fellow at Indiana University and the University of Washington. He has served as president for FASEB, was the founding president of the Protein Society and was the treasurer of the American Society for Biochemistry and Molecular Biology. His research has focused on protein chemistry and proteomics, with emphasis on the structure and function of growth factors and their receptors, particularly nerve growth factor and fibroblast growth factor, and the involvement of receptor tyrosine kinases in cell signalling. He has also studied in the role of proteolytic processing and N-terminal modification in protein stability and turnover.

    Affiliations and Expertise

    Department of Chemistry and Pharmaceutical Chemistry; and Mass Spectrometry Facility, University of California, San Francisco, Department of Physiology and Biophysics, College of Medicine, University of California, Irvine, Irvine, CA


    "The Cell Signaling Collection consists of four independent volumes which reprint articles from the second edition of the </Handbook of Cell Signaling/> carefully selected to alert medical and biological scientists to recent developments in the study of cellular signaling. This volume contains 57 articles exploring transduction mechanisms. After an overview of intracellular signaling, they cover phosporylation and dephosphorylation in kinases and phosphates, lipid signaling, cyclic nucleotides, and G proteins. The other volumes cover the functioning of transmembrane receptors, the regulation of organelle and cell compartment signaling, and intracellular signaling in development and disease."--Reference and Research Book News

    "For professionals, graduate researchers, and graduate students in biochemistry, biology, genetics, and biomedicine, Dennis (chemistry and biochemistry and pharmacology, U. of California, San Diego) and Bradshaw (chemistry and pharmaceutical chemistry, U. of California, San Francisco) bring together 52 articles from the authors' </Handbook of Cell Signaling/> on cell-cell signaling, signaling development, and signaling in disease. A group of biologists, chemists, oncologists, surgeons, and other scientists from the US, Europe, Singapore, and Australia emphasize the role of cell-cell interaction and organ and tissue effects in signaling activities and their disease implications. They do not cover other aspects of cell signaling like transmembrane receptor structure, receptor organization and function, intracellular signaling mechanisms, and transcriptional activation and responses in other organelles."--Reference and Research Book News

    Ratings and Reviews