Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression

Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression

1st Edition - January 1, 1982

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  • Editor: Marianne Grunberg-Manago
  • eBook ISBN: 9780444601247

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Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression presents the proceedings of the Fogarty International Conference on Translational/Transcriptional Regulation of Gene Expression, held at the National Institutes of Health in Bethesda, Maryland, on April 7-9, 1982. Speakers discussed the molecular strategies at work during the modulation of gene expression following transcriptional initiation. They also discussed recent developments in a number of key areas in which transcriptional and translational components interact. Organized into five sections encompassing 36 chapters, this volume explores both prokaryotic and eukaryotic systems, as well as structure-function correlations. It begins with an overview of translational/transcriptional controls in prokaryotes, the regulation of gene expression by transcription termination and RNA processing, and the structure and expression of initiation factor genes. It then examines the effect of the codon context on translational fidelity, including mistranslation of messenger RNA; protein synthesis for the construction of cell architecture; regulation of initiation factor activity; and translational regulation in cells. This book is a valuable resource for Fogarty International Scholars who want to broaden their knowledge and contribute their expertise to the National Institutes of Health community.

Table of Contents

  • Preface

    Section I: Translational/Transcriptional Controls in Prokaryotes

    The Regulation of Gene Expression by Transcription Termination and RNA Processing

    Attenuation in the Control of Tryptophan Operon Expression

    Organisation and Expression of the E. Coli Phenylalanyl-Transfer RNA Synthetase Operon

    Genes for Two E.. Coli Aminoacyl tRNA Synthetases

    Structure and Regulation of E. Coli Glutaminyl-tRNA Synthetase

    Construction of the Bacteriophage T4 Replication Machine: Regulation of Synthesis of Component Proteins

    Control of Translation by the regA Gene of T4 Bacteriophage

    Regulation of Ribosome Biosynthesis in Escherichia Coli

    Properties of a Yeast tRNAphe Amber Suppressor

    Regulation of an Eleven Gene Ribosomal Protein Operon

    Ribosomal Protein L10 and SI Control their own Synthesis

    Use of Dipeptide Synthesis to Study the In Vitro Expression of the L10 (β) Operon

    The Structure and Expression of Initiation Factor Genes

    Regulation of the Expression of tufA and tufB, the Two Genes Encoding the Elongation Factor EF-Tu in E. Coli

    Determinants of Translational Specificity in Bacillus subtilis

    Section II: Codon Context and Translational Fidelity

    Site Directed Mutagenesis of the Anticodon Region: The "Universal U" is not Essential to tRNA Synthesis and Function

    Properties of a Yeast tRNAPhe Amber Suppressor

    The Effect of Codon Context on Mistranslation of Messenger RNA

    Ribosomal Frameshift Errors Control the Expression of an Overlapping Gene in RNA Phage

    Section III: Structure and Eukaryotic Translation

    Protein Synthesis for the Construction of Cell Architecture

    Messenger RNA Conformation and the Regulation of Protein Synthesis

    Function and Topography of Components of Initiation Complexes of Eukaryotic Translation

    The Protein Translocation Machinery of the Endoplasmic Reticulum

    Section IV: Regulation of Initiation Factor Activity

    The Control of the Rate of Protein Synthesis Initiation

    The Mechanism of Translational Inhibition in Hemin-Deficient Lysates

    The Control of Polypeptide Chain Initiation by Phosphorylation of the a Subunit of the Initiation Factor eIF-2

    Protein Synthesis Initiation and Ifcs Regulation in Reticulocyte Lysates by eIF-2 and eIF-2-Ancillary Protein Factors

    Interactions of Cap Binding Proteins with Eukaryotic mRNAs

    Cap Function and Regulation of Translation During Poliovirus Infection

    Cap Binding Protein Related Polypeptides in Cytoplasmic Ribonucleoprotein Particles of Chick Embryonic Muscle

    The Role of mRNA Competition in Regulating Translation in Normal Fibroblasts

    Section V: Translations Regulation in Cells

    Mechanisms of Interferon Action: Characteristics of RNase L, the (2’-5’)(A)n- Dependent Endoribonuclease

    Expression of Human Fibroblast and Human Immune Interferon Genes in Homologous and Heterologous cells

    VAI RNA Plays a Role in Adenovirus Late mRNA Translation

    Some Aspects of Metabolic Regulation of Translation in Cultured Eukaryotic Cells

    Fertilization Triggers Rapid Sequence-Specific Changes in the Translational Activities of Individual Messenger RNAs

    Heat Shock in Saccharomyces Cerevisiae: Quantitation of Transcriptional and Translational Effects

    Concluding Remarks


Product details

  • No. of pages: 536
  • Language: English
  • Copyright: © Elsevier 1982
  • Published: January 1, 1982
  • Imprint: Elsevier
  • eBook ISBN: 9780444601247

About the Editor

Marianne Grunberg-Manago

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