Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression - 1st Edition - ISBN: 9780444007605, 9780444601247

Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression

1st Edition

Editors: Marianne Grunberg-Manago
eBook ISBN: 9780444601247
Imprint: Elsevier
Published Date: 1st January 1982
Page Count: 536
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Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression presents the proceedings of the Fogarty International Conference on Translational/Transcriptional Regulation of Gene Expression, held at the National Institutes of Health in Bethesda, Maryland, on April 7-9, 1982. Speakers discussed the molecular strategies at work during the modulation of gene expression following transcriptional initiation. They also discussed recent developments in a number of key areas in which transcriptional and translational components interact.
Organized into five sections encompassing 36 chapters, this volume explores both prokaryotic and eukaryotic systems, as well as structure-function correlations. It begins with an overview of translational/transcriptional controls in prokaryotes, the regulation of gene expression by transcription termination and RNA processing, and the structure and expression of initiation factor genes. It then examines the effect of the codon context on translational fidelity, including mistranslation of messenger RNA; protein synthesis for the construction of cell architecture; regulation of initiation factor activity; and translational regulation in cells. This book is a valuable resource for Fogarty International Scholars who want to broaden their knowledge and contribute their expertise to the National Institutes of Health community.

Table of Contents

Preface Section I: Translational/Transcriptional Controls in Prokaryotes The Regulation of Gene Expression by Transcription Termination and RNA Processing Attenuation in the Control of Tryptophan Operon Expression Organisation and Expression of the E. Coli Phenylalanyl-Transfer RNA Synthetase Operon Genes for Two E.. Coli Aminoacyl tRNA Synthetases Structure and Regulation of E. Coli Glutaminyl-tRNA Synthetase Construction of the Bacteriophage T4 Replication Machine: Regulation of Synthesis of Component Proteins Control of Translation by the regA Gene of T4 Bacteriophage Regulation of Ribosome Biosynthesis in Escherichia Coli Properties of a Yeast tRNAphe Amber Suppressor Regulation of an Eleven Gene Ribosomal Protein Operon Ribosomal Protein L10 and SI Control their own Synthesis Use of Dipeptide Synthesis to Study the In Vitro Expression of the L10 (β) Operon The Structure and Expression of Initiation Factor Genes Regulation of the Expression of tufA and tufB, the Two Genes Encoding the Elongation Factor EF-Tu in E. Coli Determinants of Translational Specificity in Bacillus subtilis Section II: Codon Context and Translational Fidelity Site Directed Mutagenesis of the Anticodon Region: The "Universal U" is not Essential to tRNA Synthesis and Function Properties of a Yeast tRNAPhe Amber Suppressor The Effect of Codon Context on Mistranslation of Messenger RNA Ribosomal Frameshift Errors Control the Expression of an Overlapping Gene in RNA Phage Section III: Structure and Eukaryotic Translation Protein Synthesis for the Construction of Cell Architecture Messenger RNA Conformation and the Regulation of Protein Synthesis Function and Topography of Components of Initiation Complexes of Eukaryotic Translation The Protein Translocation Machinery of the Endoplasmic Reticulum Section IV: Regulation of Initiation Factor Activity T


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© Elsevier 1982
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About the Editor

Marianne Grunberg-Manago

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