Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression - 1st Edition - ISBN: 9780444007605, 9780444601247

Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression

1st Edition

Editors: Marianne Grunberg-Manago
eBook ISBN: 9780444601247
Imprint: Elsevier
Published Date: 1st January 1982
Page Count: 536
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Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression presents the proceedings of the Fogarty International Conference on Translational/Transcriptional Regulation of Gene Expression, held at the National Institutes of Health in Bethesda, Maryland, on April 7-9, 1982. Speakers discussed the molecular strategies at work during the modulation of gene expression following transcriptional initiation. They also discussed recent developments in a number of key areas in which transcriptional and translational components interact.
Organized into five sections encompassing 36 chapters, this volume explores both prokaryotic and eukaryotic systems, as well as structure-function correlations. It begins with an overview of translational/transcriptional controls in prokaryotes, the regulation of gene expression by transcription termination and RNA processing, and the structure and expression of initiation factor genes. It then examines the effect of the codon context on translational fidelity, including mistranslation of messenger RNA; protein synthesis for the construction of cell architecture; regulation of initiation factor activity; and translational regulation in cells. This book is a valuable resource for Fogarty International Scholars who want to broaden their knowledge and contribute their expertise to the National Institutes of Health community.

Table of Contents


Section I: Translational/Transcriptional Controls in Prokaryotes

The Regulation of Gene Expression by Transcription Termination and RNA Processing

Attenuation in the Control of Tryptophan Operon Expression

Organisation and Expression of the E. Coli Phenylalanyl-Transfer RNA Synthetase Operon

Genes for Two E.. Coli Aminoacyl tRNA Synthetases

Structure and Regulation of E. Coli Glutaminyl-tRNA Synthetase

Construction of the Bacteriophage T4 Replication Machine: Regulation of Synthesis of Component Proteins

Control of Translation by the regA Gene of T4 Bacteriophage

Regulation of Ribosome Biosynthesis in Escherichia Coli

Properties of a Yeast tRNAphe Amber Suppressor

Regulation of an Eleven Gene Ribosomal Protein Operon

Ribosomal Protein L10 and SI Control their own Synthesis

Use of Dipeptide Synthesis to Study the In Vitro Expression of the L10 (β) Operon

The Structure and Expression of Initiation Factor Genes

Regulation of the Expression of tufA and tufB, the Two Genes Encoding the Elongation Factor EF-Tu in E. Coli

Determinants of Translational Specificity in Bacillus subtilis

Section II: Codon Context and Translational Fidelity

Site Directed Mutagenesis of the Anticodon Region: The "Universal U" is not Essential to tRNA Synthesis and Function

Properties of a Yeast tRNAPhe Amber Suppressor

The Effect of Codon Context on Mistranslation of Messenger RNA

Ribosomal Frameshift Errors Control the Expression of an Overlapping Gene in RNA Phage

Section III: Structure and Eukaryotic Translation

Protein Synthesis for the Construction of Cell Architecture

Messenger RNA Conformation and the Regulation of Protein Synthesis

Function and Topography of Components of Initiation Complexes of Eukaryotic Translation

The Protein Translocation Machinery of the Endoplasmic Reticulum

Section IV: Regulation of Initiation Factor Activity

The Control of the Rate of Protein Synthesis Initiation

The Mechanism of Translational Inhibition in Hemin-Deficient Lysates

The Control of Polypeptide Chain Initiation by Phosphorylation of the a Subunit of the Initiation Factor eIF-2

Protein Synthesis Initiation and Ifcs Regulation in Reticulocyte Lysates by eIF-2 and eIF-2-Ancillary Protein Factors

Interactions of Cap Binding Proteins with Eukaryotic mRNAs

Cap Function and Regulation of Translation During Poliovirus Infection

Cap Binding Protein Related Polypeptides in Cytoplasmic Ribonucleoprotein Particles of Chick Embryonic Muscle

The Role of mRNA Competition in Regulating Translation in Normal Fibroblasts

Section V: Translations Regulation in Cells

Mechanisms of Interferon Action: Characteristics of RNase L, the (2’-5’)(A)n- Dependent Endoribonuclease

Expression of Human Fibroblast and Human Immune Interferon Genes in Homologous and Heterologous cells

VAI RNA Plays a Role in Adenovirus Late mRNA Translation

Some Aspects of Metabolic Regulation of Translation in Cultured Eukaryotic Cells

Fertilization Triggers Rapid Sequence-Specific Changes in the Translational Activities of Individual Messenger RNAs

Heat Shock in Saccharomyces Cerevisiae: Quantitation of Transcriptional and Translational Effects

Concluding Remarks



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© Elsevier 1982
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About the Editor

Marianne Grunberg-Manago

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