An integrin, or integrin receptor, is an integral membrane protein in the plasma membrane of cells. It plays a role in the attachment of a cell to the extracellular matrix (ECM) and to other cells, and in signal transduction from the ECM to the cell. There are many types of integrin, and many cells have multiple types on their surface. Integrins are of vital importance to all metazoans, from humans to sponges. This volume in Methods in Enzymology presents methods for studying integrins.


Biochemists and researchers in related life science fields.

Table of Contents

Chapter 1: Quantitative Measurements of Integrin-Mediated Adhesion to Extracellular Matrix Chapter 2: Investigating Integrin regulation and signaling events in three dimensional systems Chapter 3: Integrins in Cell Migration Chapter 4: Imtegrin Cytoskeletal Interacions Chapter 5: Cell Survival in a 3D Matrix Chapter 6: Platelet Integrin Adhesive Functions and Signaling Chapter 7: Development of Monoclonal Antibodies to Integrin Receptors Chapter 8: Cell adhesion, cellular tension, and cell cycle control Chapter 9: Analysis of Integrin Signaling by Fluorescence Resonance Energy Transfer Chapter 10: Studies on integrins in the nervous system Chapter 11: Methods for identifying novel integrin ligands Chapter 12: Analysis of integrin functions in peri-implantation embryos, hematopoietic system and skin Chapter 13: Identification and molecular characterization of multiple phenotypes in integrin knockout mice Chapter 14: Purification, Analysis and Crystal Structure of Integrins Chapter 15: Electron Microscopy of Integrins Chapter 16: Intravital Imaging and Cell Invasion Chapter 17: Using Xenopus Embryos to Investigate Integrin Function Chapter 18: Methods to Study Lymphatic Vessel Integrins Chapter 19: Analysis of Integrin Signaling in Genetically Engineered Mouse Models of Mammary Tumor Progression Chapter 20: Design and Chemical Synthesis of Integrin Ligands


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© 2007
Academic Press
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About the serial-volume-editor

David Cheresh

Affiliations and Expertise

The Scripps Research Institute, La Jolla, CA, USA