1st Edition - August 27, 2007

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  • Editor: David Cheresh
  • Hardcover ISBN: 9780123739247
  • eBook ISBN: 9780080551388

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An integrin, or integrin receptor, is an integral membrane protein in the plasma membrane of cells. It plays a role in the attachment of a cell to the extracellular matrix (ECM) and to other cells, and in signal transduction from the ECM to the cell. There are many types of integrin, and many cells have multiple types on their surface. Integrins are of vital importance to all metazoans, from humans to sponges. This volume in Methods in Enzymology presents methods for studying integrins.


Biochemists and researchers in related life science fields.

Table of Contents

  • Chapter 1: Quantitative Measurements of Integrin-Mediated Adhesion to Extracellular Matrix

    Chapter 2: Investigating Integrin regulation and signaling events in three dimensional systems

    Chapter 3: Integrins in Cell Migration

    Chapter 4: Imtegrin Cytoskeletal Interacions

    Chapter 5: Cell Survival in a 3D Matrix

    Chapter 6: Platelet Integrin Adhesive Functions and Signaling

    Chapter 7: Development of Monoclonal Antibodies to Integrin Receptors

    Chapter 8: Cell adhesion, cellular tension, and cell cycle control

    Chapter 9: Analysis of Integrin Signaling by Fluorescence Resonance Energy Transfer

    Chapter 10: Studies on integrins in the nervous system

    Chapter 11: Methods for identifying novel integrin ligands

    Chapter 12: Analysis of integrin functions in peri-implantation embryos, hematopoietic system and skin

    Chapter 13: Identification and molecular characterization of multiple phenotypes in integrin knockout mice

    Chapter 14: Purification, Analysis and Crystal Structure of Integrins

    Chapter 15: Electron Microscopy of Integrins

    Chapter 16: Intravital Imaging and Cell Invasion

    Chapter 17: Using Xenopus Embryos to Investigate Integrin Function

    Chapter 18: Methods to Study Lymphatic Vessel Integrins

    Chapter 19: Analysis of Integrin Signaling in Genetically Engineered Mouse Models of Mammary Tumor Progression

    Chapter 20: Design and Chemical Synthesis of Integrin Ligands

Product details

  • No. of pages: 616
  • Language: English
  • Copyright: © Academic Press 2007
  • Published: August 27, 2007
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123739247
  • eBook ISBN: 9780080551388

About the Serial Volume Editor

David Cheresh

Affiliations and Expertise

The Scripps Research Institute, La Jolla, CA, USA

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