Integrating the Neurobiology of Schizophrenia

Integrating the Neurobiology of Schizophrenia

1st Edition - February 27, 2007

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  • Editors: Anissa Abi-Dargham, Olivier Guillin
  • Hardcover ISBN: 9780123737373
  • eBook ISBN: 9780080475080

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This book examines the role that dopamine plays in schizophrenia, examining its role in not only the symptoms of the disease but also in its treatment. It also reviews all neurotransmitters that have been implicated in schizophrenia, exploring the genetic data, clinical data implicating the transmitter, and the preclinical data exploring how a transmitter may interact with dopamine and contribute to the dopaminergic phenotype observed in the illness. This book will serve as an educational tool for instructors, a guide for clinicians, and be of interest to researchers. It is a good reference for researchers specialized in one particular area and interested in learning about other areas of pathology in schizophrenia and how they may all feed into each other. The book concludes with an overall integrative model assembling as many of these elements as possible.


Neuroscientists, neurologists.

Table of Contents

  • Neurobiology of Dopamine in Schizophrenia

    I Introduction

    II Dopaminergic System in the Brain

    III Evidence Supporting Alterations of DA Systems in Schizophrenia

    IV Conclusions

    The Dopamine System and the Pathophysiology of Schizophrenia: A Basic Science Perspective

    I Introduction

    II Neuroanatomy of DA Systems

    III DA Neuron Activity and Release

    IV Cellular Actions of DA

    V Roles of DA on Cognitive and Affective Functions

    VI Development and Maturation of the DA System

    VII DA Deficits in Schizophrenia

    VIII Conclusions

    Glutamate and Schizophrenia: Phencyclidine, N-Methyl-d-Aspartate Receptors, and Dopamine–Glutamate Interactions

    I Introduction

    II Glutamatergic Physiology

    III Glutamatergic Models of Schizophrenia

    IV Clinical Studies with NMDA Agonists

    V Potential Causes of Glutamatergic Dysfunction in Schizophrenia

    VI Future Research and Treatment Implications

    Deciphering the Disease Process of Schizophrenia: The Contribution of Cortical Gaba Neurons

    I Working Memory Impairments: A Core Feature of Schizophrenia

    II Working Memory Impairments and Altered GABA Neurotransmission in the DLPFC

    III Potential Pathogenetic Mechanisms for Cell Type-Specific Alterations in GABA Neurons

    IV Connecting Alterations in PV-Positive Neurons to Working Memory Impairments: Decreased Gamma Band Synchrony in Schizophrenia

    V Treatment Implications

    Alterations of Serotonin Transmission in Schizophrenia

    I Introduction

    II Alteration of 5-HT Receptors in Schizophrenia

    III Pharmacological Manipulation of 5-HT Transmission in Schizophrenia

    IV 5‐HT–DA Interactions Relevant to Schizophrenia

    V Discussions

    Serotonin and Dopamine Interactions in Rodents and Primates: Implications for Psychosis and Antipsychotic Drug Development

    I Introduction

    II Dopamine and 5-HT Receptors

    III Psychomotor Stimulants: A Dopamine–Serotonin Interaction Case Study

    IV Monoaminergic Nuclei Interactions

    V Serotonin and Dopamine in the Thalamus

    VI Dopamine and Serotonin in the Striatum

    VII Dopamine and Serotonin in the Hippocampal Formation

    VIII Dopamine and Serotonin in the Prefrontal Cortex/Neocortex

    IX Animal Models

    X Conclusions

    Cholinergic Circuits and Signaling in the Pathophysiology of Schizophrenia

    I Introduction

    II ACh in Brain Regions Implicated in Schizophrenia

    III Physiology of ACh Circuits and Signaling in Brain Regions Implicated in Schizophrenia Pathology

    IV Developmental and Genetic Deficits in Schizophrenia That May Influence Function and Assembly of Cholinergic Systems

    V Clinical and Preclinical Evidence for Deficits in Components of Brain Cholinergic Systems in Schizophrenia

    VI Evidence for Cholinergic Contributions to Schizophrenia Pathophysiology from Clinical and Preclinical Psychopharmacology

    VII Conclusions

    Schizophrenia and the α7 Nicotinic Acetylcholine Receptor

    I Introduction

    II Neurobiological and Neurogenetic Evidence for a Link Between the α7 Nicotinic Acetylcholine Receptor and Schizophrenia

    III The Prototypic α7 Nicotinic Agonist, Nicotine, and Schizophrenia

    IV The Search for an α7 Nicotinic Acetylcholine Receptor Agonist

    V The Phase 1 Study of DMXBA in Schizophrenia

    Histamine and Schizophrenia

    I Introduction

    II The Histaminergic Neuronal System

    III Changes in the Histaminergic System in Schizophrenia

    IV Interactions of Antipsychotic Drugs with the Histaminergic System

    V Role of Histaminergic Neurons in Schizophrenia

    VI Conclusions

    Cannabinoids and Psychosis

    I Introduction

    II Ancedotal Reports

    III Epidemiological Studies

    IV Pharmacological Studies

    V Cannabis and Psychosis: Causality

    VI Cannabinoid Receptor Dysfunction and Psychotic Disorders

    VII Summary and Conclusions

    Involvement of Neuropeptide Systems in Schizophrenia: Human Studies

    I Introduction

    II Cholecystokinin

    III Corticotropin-Releasing Factor

    IV Interleukins

    V Neurotensin

    VI Neuropeptide Y

    VII Opioid Peptides

    VIII Secretin

    IX Somatostatin

    X Vasoactive Intestinal Peptide

    XI Tachykinins

    XII Thyrotropin‐Releasing Hormone

    XIII Other Peptides

    XIV Conclusions


    Brain-Derived Neurotrophic Factor in Schizophrenia and Its Relation With Dopamine

    I Introduction

    II Genetic Studies

    III BDNF in the Serum of Patients with Schizophrenia

    IV BDNF and TrkB Receptor in the Brain of Patients with Schizophrenia

    V Dopamine–BDNF Interactions

    VI Conclusions

    Schizophrenia Susceptibility Genes: in Search of A Molecular Logic and Novel Drug Targets for A Devastating Disorder

    I The Genetic Component of Schizophrenia

    II Genes Identified Through Systematic Follow-Up of Linkage Signals

    III Other Candidate Genes

    IV Areas of Caution in the Interpretation and Generalization of Genetic Findings

    V Future Directions of the Genetic Research: Advancing Our Understanding of How the Specific Genetic Factors Contribute Biologically to the Disease Process

    Series Editors

    Contributors to Volume 78



    Contents of Recent Volumes

Product details

  • No. of pages: 480
  • Language: English
  • Copyright: © Academic Press 2007
  • Published: February 27, 2007
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123737373
  • eBook ISBN: 9780080475080

About the Serial Volume Editors

Anissa Abi-Dargham

Olivier Guillin

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