Baculoviruses are perhaps unique among viruses in the breadth of their biotechnological applications: these insect specific viruses are used not only for insect pest management purposes, but also as laboratory research tools for production of recombinant proteins and for protein display, and as potential vectors for human gene therapy. In addition to highlighting recent advances, this volume provides a comprehensive review of the biotechnological applications of these and other insect viruses in both the academic and private sectors.


Researchers and postgraduates within academia and industry working in virology, entomology, biotechnology, insect pest management and biological control, human gene therapy, vaccinology, plant pathology, drug discovery, and genetics

Table of Contents

Insect Viruses as Laboratory Research Tools Milestones Leading to the Genetic Engineering of Baculoviruses as Expression Vector Systems and Viral Pesticides Polydnavirus genes that enhance the baculovirus expression vector system Baculovirus Display: A Multi-Functional Technology for Gene Delivery and Eukaryotic Library Development Stably transformed insect cell lines: Tools for expression of secreted and membrane-anchored proteins and high throughput screening platforms for drug and insecticide discovery Applications to Human and Animal Health Protein N-glycosylation in the baculovirus-insect cell expression system and efforts to engineer insect cells to produce “mammalianized” recombinant glycoproteins Vaccines for viral and parasitic diseases produced with baculovirus vectors Baculoviruses and Mammalian Cell-Based Assays for Drug Screening Baculovirus Vectors for Gene Therapy Insect Pest Management Genetically Modified Baculoviruses: A Historical Overview and Future Outlook Densoviruses for Control and Genetic Manipulation of Mosquitoes Potential Uses of Cys-Motif and Other Polydnavirus Genes in Biotechnology Virus-derived genes for insect resistant transgenic plants Small RNA Viruses of Insects: Expression in Plants and RNA Silencing.


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© 2006
Academic Press
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