Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells - 1st Edition - ISBN: 9780128038147, 9780128038871

Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells

1st Edition

Editors: Kenneth Lo
eBook ISBN: 9780128038871
Paperback ISBN: 9780128038147
Imprint: Academic Press
Published Date: 6th January 2017
Page Count: 406
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Description

Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells provides a complete overview of this important research area that is perfect for both newcomers and expert researchers in the field. Through concise chapters written and edited by esteemed experts, this book brings together a comprehensive treatment of the area previously only available through scattered, lengthy review articles in the literature. Advanced topics of research are covered, with particular focus on recent advances in the biological applications of transition metal complexes, including inorganic medicine, enzyme inhibitors, antiparasital agents, and biological imaging reagents.

Key Features

  • Geared toward researchers and students who seek an introductory overview of the field, as well as researchers working in advanced areas
  • Focuses on the interactions of inorganic and organometallic transition metal complexes with biological molecules and live cells
  • Foscuses on the fundamentals and their potential therapeutic and diagnostic applications
  • Covers recent biological applications of transition metal complexes, such as anticancer drugs, enzyme inhibitors, bioconjugation agents, chemical biology tools, and bioimaging reagents

Readership

Inorganic chemistry, medicinal chemistry, and drug development researchers; secondarily advanced chemistry and biology students

Table of Contents

  • List of Contributors
  • Preface
  • Chapter One. Luminescent Zinc Complexes as Bioprobes for Imaging Molecular Events in Live Cells
    • 1. Introduction
    • 2. General Considerations
    • 3. Luminescent Zinc Complexes as Bioprobes
    • 4. Conclusion and Outlook
  • Chapter Two. Cellular Uptake and Sensing Capability of Transition Metal Peptide Conjugates
    • 1. Introduction
    • 2. Transition Metal Complexes for Cell Imaging and Sensing
    • 3. Cell-Penetrating Peptides
    • 4. Mechanism of CPP Uptake
    • 5. CPP Modified Transition Metal Luminophores for Sensing and Imaging
    • 6. Signal Peptide-Modified Transition Metal Luminophores
    • 7. Conclusions and Future Outlook
  • Chapter Three. Luminescent Rhenium(I) and Iridium(III) Complexes for Intracellular Labeling, Sensing, and Photodynamic Therapy Applications
    • 1. Introduction
    • 2. Intracellular Labels
    • 3. Intracellular Sensors
    • 4. Ratiometric Sensors
    • 5. Photodynamic Therapy
    • 6. Conclusion
  • Chapter Four. Organoruthenium(II)-Arene Complexes: Structural Building Blocks for Anticancer Drug Discovery
    • 1. Introduction
    • 2. Accessing the Ruthenium(II)-Arene Scaffold
    • 3. Ru(II)-Arene Drug Candidates Under Investigation
    • 4. Cytotoxic Ru(II)-Arene Complexes via Classical Approaches
    • 5. Nonclassical Ru(II)-Arene Complexes by Rational Design
    • 6. Nonclassical Ru(II)-Arene Complexes From Classical Approaches
    • 7. Conclusion
  • Chapter Five. Medicinal Chemistry of Metal N-Heterocyclic Carbene (NHC) Complexes
    • 1. Introduction
    • 2. Metal NHC Complexes With Classical N–C–N Carbene Ligands
    • 3. Metal NHC Complexes With “Nonclassical” NHC Ligands and Heterobimetallic Metal NHC Complexes
    • 4. Metal NHC Complexes With Biologically Active, Biogenic, or Targeting Ligands
    • 5. Conclusions
  • Chapter Six. Metal Complexes as Delivery Systems for CO, NO, and H2S to Explore the Signaling Network of Small-Molecule Messengers
    • 1. Introduction
    • 2. Enzymatic Generation of CO, NO, and H2S
    • 3. Delivery Systems for CO, NO, and H2S
    • 4. Molecular Probes for Small-Molecule Messengers
    • 5. Cellular Target Structures of CO, NO, and H2S
    • 6. Summary
  • Chapter Seven. Antimicrobial Metallodrugs
    • 1. Introduction
    • 2. Redox-Active Metal Complexes
    • 3. Complexes With Reactive Metal Centers
    • 4. Complexes That Release Carbon Monoxide
    • 5. Metal Centers as Structural Templates
    • 6. Outlook
  • Chapter Eight. Carbon Nanotubes and Related Nanohybrids Incorporating Inorganic Transition Metal Compounds and Radioactive Species as Synthetic Scaffolds for Nanomedicine Design
    • 1. Introduction
    • 2. Positron Emission Tomography–Single-Photon Emission Computed Tomography Metal Complex Bioconjugates
    • 3. Potential Application of Carbon Nanomaterial Nanohybrids Incorporating Inorganic Transition Metal Complexes in Biomedical Applications
    • 4. Conclusions and Future Prospects
  • Chapter Nine. Immobilized Metal Affinity Chromatography (IMAC) for Metalloproteomics and Phosphoproteomics
    • 1. Introduction
    • 2. Principles and Design of Immobilized Metal Affinity Chromatography Columns
    • 3. Immobilized Metal Affinity Chromatography for Metalloproteomic Study
    • 4. Immobilized Metal Affinity Chromatography for the Analysis of Protein Phosphorylation
    • 5. Novel Polymer-Based Metal Ion Affinity Capture: Alternative to Immobilized Metal Affinity Chromatography
    • 6. Conclusion
  • Chapter Ten. The Analysis of Therapeutic Metal Complexes and Their Biomolecular Interactions
    • 1. Introduction
    • 2. Metallodrug Binding to Blood Serum Proteins
    • 3. Tissue Distribution and Cellular Accumulation
    • 4. Cellular Targets
    • 5. Conclusions
  • Index

Details

No. of pages:
406
Language:
English
Copyright:
© Academic Press 2017
Published:
Imprint:
Academic Press
eBook ISBN:
9780128038871
Paperback ISBN:
9780128038147

About the Editor

Kenneth Lo

Professor Kenneth Lo obtained his PhD degree in 1997 at The University of Hong Kong. His PhD work centered on the design of luminescent transition metal complexes as DNA and metal-ion probes; and the photophysical and photochemical studies of luminescent polynuclear coinage metal chalcogenide complexes. From 1997 to 1999, he worked as a Croucher Foundation Postdoctoral Research Fellow in the Inorganic Chemistry Laboratory, University of Oxford. He carried out research work on genetic engineering and electrochemistry of cytochrome P450cam and putidaredoxin. Professor Lo joined the Department of Biology and Chemistry of City University of Hong Kong as Assistant Professor in 1999 and became Associate Professor (Scale B) in 2003, Associate Professor (Scale A) in 2007, and Professor in 2011. Professor Lo’s research interest is the utilization of luminescent inorganic and organometallic transition metal complexes as biomolecular and cellular probes, with a focus on the development of intracellular sensors, photoactive labels, and bioimaging reagents. He received The APA Prize for Young Scientist from the Asian and Oceanian Photochemistry Association in 2005 and the Distinguished Lectureship Award from the Chemical Society of Japan in 2011. He is currently on the Editorial Advisory Board of Inorganic Chemistry and is an Associate Editor of RSC Advances. He isone of the Vice Chairs of the Gordon Research Conference Metals in Medicine 2016. He was awarded a Croucher Senior Research Fellowship (2015 – 2016) from the Croucher Foundation.

Affiliations and Expertise

City University of Hong Kong, China