Description

Novel injectable materials for non-invasive surgical procedures are becoming increasingly popular. An advantage of these materials include easy deliverability into the body, however the suitability of their mechanical properties must also be carefully considered. Injectable biomaterials covers the materials, properties and biomedical applications of injectable materials, as well as novel developments in the technology.

Part one focuses on materials and properties, with chapters covering the design of injectable biomaterials as well as their rheological properties and the mechanical properties of injectable polymers and composites. Part two covers the clinical applications of injectable biomaterials, including chapters on drug delivery, tissue engineering and orthopaedic applications as well as injectable materials for gene delivery systems. In part three, existing and developing technologies are discussed. Chapters in this part cover such topics as environmentally responsive biomaterials, injectable nanotechnology, injectable biodegradable materials and biocompatibility. There are also chapters focusing on troubleshooting and potential future applications of injectable biomaterials.

With its distinguished editor and international team of contributors, Injectable biomaterials is a standard reference for materials scientists and researchers working in the biomaterials industry, as well as those with an academic interest in the subject. It will also be beneficial to clinicians.

Key Features

  • Comprehensively examines the materials, properties and biomedical applications of injectable materials, as well as novel developments in the technology
  • Reviews the design of injectable biomaterials as well as their rheological properties and the mechanical properties of injectable polymers and composites
  • Explores clinical applications of injectable biomaterials, including drug delivery, tissue engineering, orthopaedic applications and injectable materials for gene delivery systems

Readership

Professionals and academics.

Table of Contents

Contributor contact details

Part I: Materials and properties

Chapter 1: Designing clinically useful substitutes for the extracellular matrix

Abstract:

1.1 Introduction: the translational challenge

1.2 Design criteria for extracellular matrix (ECM) mimetics

1.3 Single-module semi-synthetic extracellular matrices (sECMs) based on hyaluronic acid (HA)

1.4 Adding function to hyaluronic acid (HA) matrices

1.5 Using injectable synthetic extracellular matrices (sECMs) in vivo

1.6 Conclusions and future trends

Chapter 2: Designing ceramics for injectable bone graft substitutes

Abstract:

2.1 Introduction

2.2 Rheological properties of bone substitute pastes

2.3 Handling and delivery

2.4 Mechanical and biological properties of bone substitute pastes

2.5 Industrial design

2.6 Future trends

Chapter 3: Rheological properties of injectable biomaterials

Abstract:

3.1 Introduction

3.2 Different types of in situ gelling materials: chemical gels, solvent exchange, and physical gels

3.3 Shrinkage, swelling, and evaporation

3.4 Kinetics and injectability

3.5 The role of statistics and uncertainty in rheological characterization

3.6 Future trends

3.7 Sources of further information and advice

Chapter 4: Improving mechanical properties of injectable polymers and composites

Abstract:

4.1 Introduction

4.2 Mechanical properties and testing

4.3 Injectable hydrogels

4.4 Non–hydrogel injectable polymers

4.5 Conclusion and future trends

Part II: Clinical applications

Chapter 5: Drug delivery applications of injectable biomaterials

Abstract:

5.1 Introduction

5.2 Solvent exchange precipitating materials

5.3 Aqueous solubility change materials

5.4 In situ crosslinking or po

Details

No. of pages:
432
Language:
English
Copyright:
© 2011
Published:
Imprint:
Woodhead Publishing
Electronic ISBN:
9780857091376
Print ISBN:
9781845695880
Print ISBN:
9780081014936

About the editor

Brent Vernon

Brent Vernon is Associate Professor of Bioengineering at Arizona State University, USA.