Initiation and Termination of Cylic Nucleotide Action, Volume 159

1st Edition

Serial Volume Editors: Jackie Corbin Roger Johnson
Editor-in-Chiefs: John Abelson Melvin Simon
Hardcover ISBN: 9780121820602
eBook ISBN: 9780080882765
Imprint: Academic Press
Published Date: 28th June 1988
Page Count: 850


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Table of Contents

Cyclic Nucleotide Cascades:

E. Shacte, E.R. Stadtman, S.R. Jurgensen, and P.B. Chock, Role of cAMP in Cyclic Cascade Regulation.

S. Swillens, J.-M. Boeynaems, and J.E. Dumont, Theoretical Considerations of the Regulatory Steps in the cAMP Cascade System.

T. Ishikawa, K. Matsumoto, and I. Uno, Yeast Mutants Altered in the cAMP Cascade Systems.

Assays of Cyclic Nucleotide Levels, Turnover, and Transport:

G. Brooker, Improvements in the Automated Radioimmunoassay for cAMP or cGMP.

R. Barber and R.W. Butcher, cAMP turnover in Intact Cells.

T.F. Walseth, R.M. Graeff, and N.D. Goldberg, Monitoring Cyclic Nucleotide Metabolism in Intact Cells by 180 Labeling.

J.D. Corbin, T.W. Gettys, P.F. Blackmore, S.J. Beebe, S.H. Francis, D.B. Glass, J.B. Redmon, V.S. Sheorain, and L.R. Landiss, Purification and Assay of cAMP, cGMP, AND Cyclic Nucleotide Analogs in Cells Treated with Cyclic Nucleotide Analogs.

L.L. Brunton and L.E. Heasley, cAMP Export and Its Regulation by Prostaglandin A1.

Cyclic Nucleotide Action: Cyclic Nucleotide Action in Mammals:

R. Ekanger and S.O. D~aloskeland, Use of Antibody-Sepharose Columns to Study Hormonal Activation of cAMP-Dependent Protein Kinase Isozymes.

S.A. Livesey and T.J. Martin, Selective Activation of the cAMP-Dependent Protein Kinase Isoenzymes.

S.J. Beebe, P.F. Blackmore, T.D. Chrisman, and J.D. Corbin, Use of Synergistic Pairs of Site-Selective cAMP Analogs in Intact Cells.

M.C. Mumby and C.W. Scott, cAMP-Dependent Protein Kinase Regulatory Subunit Phosphorylation in Intact Cells.

S.O. D~aloskeland and D. ~alOgreid, Ammonium Sulfate Precipitation Assay for the Study of Cy


Novel approaches for the study of phosphodiesterases and phosphoprotein phosphatases, as well as those of nonmammalian cyclic nucleotide receptors, are emphasized for the first time in the Methods of Enzymology series. New methods for the study of protein kinases are also presented.


Biochemists, endocrinologists, cell and molecular biologists, analytical and clinical chemists, biomedical researchers, pharmacologists, physiologists.


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© Academic Press 1988
Academic Press
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About the Serial Volume Editors

Jackie Corbin Serial Volume Editor

Affiliations and Expertise

Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, Tennessee, U.S.A.

Roger Johnson Serial Volume Editor

Affiliations and Expertise

School of Medicine Health Sciences Center, University of New York, Stony Brook, U.S.A.

About the Editor-in-Chiefs

John Abelson Editor-in-Chief

Affiliations and Expertise

California Institute of Technology, Division of Biology, Pasadena, U.S.A.

Melvin Simon Editor-in-Chief

Affiliations and Expertise

The Salk Institute, La Jolla, CA, USA