Inhibition of Polyamine Metabolism

Inhibition of Polyamine Metabolism

Biological Significance and Basis for New Therapies

1st Edition - July 9, 1987

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  • Editor: Peter McCann
  • eBook ISBN: 9780323152327

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Inhibition of Polyamine Metabolism: Biological Significance and Basis for New Therapies provides an overview of the field concerning polyamine biosynthesis inhibitors. The book is comprised of chapters which describe the compounds which are in use; the rationale for the design of such inhibitors; their synthesis and action; their biological effects on mammalian cells and tissues, plants, and microorganisms including protozoal parasites; and a review of the clinical experience with these inhibitors. The major beneficial effect which the wide availability of these inhibitors has had on the field of polyamine research in general is likewise demonstrated. Biochemists, pharmacologist, and cellular physiologists will find this text very useful.

Table of Contents

  • Preface

    Introduction: Polyamine Metabolism

    1 Inhibition of Basic Amino Acid Decarboxylases Involved in Polyamine Biosynthesis

    I. Introduction

    II. Properties of ODC

    III. Mechanism of Action of ODC

    IV. Inhibition of ODC

    V. Inhibition of Arginine Decarboxylase and Lysine Decarboxylase

    VI. Conclusion


    2 Pharmacologic Interference with Enzymes of Polyamine Biosynthesis and of 5'-Methylthioadenosine Metabolism

    I. Introduction

    II. S-Adenosylmethionine Decarboxylase (AdoMetDC)

    III. Spermidine Synthase

    IV. Spermine Synthase

    V. Enzymatic Degradation of 5'-Methylthioadenosine (MTA)


    3 Inhibition of Enzymes Oxidizing Polyamines

    I. Introduction

    II. Copper Amine Oxidases

    III. Flavin-Dependent Enzymes in Polyamine Catabolism

    IV. Biological Consequences of Polyamine Oxidase Inactivation

    V. Conclusions


    4 Molecular and Cellular Functions of the Polyamines

    I. Introduction

    II. Nucleic Acid Structure

    III. Macromolecular Synthesis

    III. Topoisomerase Activity

    IV. Membrane Structure and Function


    5 The Use of Inhibitors to Study the Biochemistry and Molecular Biology of Polyamine Biosynthesis and Uptake

    I. Introduction

    II. Studies of Ornithine Decarboxylase

    III. Studies of S-Adenosylmethionine Decarboxylase (AdoMetDC)

    IV. Studies of Polyamine Transport


    6 Inhibitors of Polyamine Biosynthesis: Cellular and in Vivo Effects on Tumor Proliferation

    I. Introduction

    II. Polyamine Biosynthesis in Normal and Transformed Cells

    III. Inhibitors of Polyamine Biosynthesis

    IV. Cellular Effects of Polyamine Inhibitors

    V. Polyamine Inhibitors: In Vivo Effects Against Experimental Tumors

    VI. Summary


    7 Polyamine Inhibition in Vivo and in Organ Growth and Repair

    I. Introduction

    II. In Vivo Biochemistry of Polyamine Biosynthesis Inhibitors

    III. Consequences of Polyamine Inhibition on Organ Growth and Repair

    IV. Conclusions


    8 Polyamine Synthesis Inhibitors Act as Both Inducers and Suppressors of Cell Differentiation

    I. Introduction

    II. Germ Cells and Embryos

    III. Organ Systems

    IV. Primary Cell Cultures and Established Cell Lines

    V. Summary and Future Prospects


    9 The Contragestational Effects of Ornithine Decarboxylase Inhibition

    I. Introduction

    II. Polyamine Biochemical Changes During Gestation in Mammals

    III. Effects of Inhibitors of ODC on Gestation

    IV. Clinical Significance of the Contragestational Effects of ODC Inhibition

    V. Conclusion


    10 Modulation of Antineoplastic Drug Action by Inhibitors of Polyamine Biosynthesis

    I. Introduction

    II. Goals of Combination Chemotherapy

    III. Approaches to Combination Chemotherapy

    IV. DFMO Effects on Polyamine Biosynthesis

    V. Targeted Drug Interactions Using Polyamine Inhibitors

    VI. Summary


    11 Inhibition of Carcinogenesis by Inhibitors of Putrescine Biosynthesis

    I. Introduction

    II. Experiments and Results

    III. Practical Consideration

    IV. Summary and Conclusions


    12 Inhibition of Polyamine Biosynthesis in Microorganisms

    I. Introduction

    II. Inhibition of Ornithine Decarboxylase

    III. Inhibition of Arginine Decarboxylase

    IV. Inhibition of S-Adenosylmethionine Decarboxylase

    V. Inhibition of Spermidine Synthase

    VI. Spermine Synthase

    VII. Mycoplasma

    VIII. Summary


    13 Inhibition of Viral Polyamine Biosynthesis

    I. Introduction

    II. Polyamine Metabolism and the Replication of Animal Viruses

    III. Qualitative and Quantitative Aspects of Antiviral Chemotherapy

    IV. Polyamines and Viral Disease

    V. Drug Combinations and Antiviral Chemotherapy

    VI. Concluding Remarks


    14 Inhibition of Polyamine Biosynthesis in Plants and Plant Pathogenic Fungi

    I. Introduction

    II. Inhibition of Polyamine Biosynthesis and Catabolism in Plants

    III. Effects of Polyamine Biosynthesis Inhibitors on Plant Growth and Development

    IV. Control of Phytopathogenic Fungi with DFMO


    15 Parasitic Protozoa and Polyamines

    I. Introduction

    II. Flagellates

    III. Sporozoea

    IV. Amoebae

    V. Conclusions


    16 Clinical Aspects of Inhibition of Ornithine Decarboxylase with Emphasis on Therapeutic Trials of Eflornithine (DFMO) in Cancer and Protozoan Diseases

    I. Introduction

    II. Malignancies

    III. African Trypanosomiasis

    IV. Pneumocystis Carinii Pneumonia (PCP)

    V. Other Indications and Future Clinical Research

    VI. Conclusions



Product details

  • No. of pages: 398
  • Language: English
  • Copyright: © Academic Press 1987
  • Published: July 9, 1987
  • Imprint: Academic Press
  • eBook ISBN: 9780323152327

About the Editor

Peter McCann

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