Ingredient X - 1st Edition - ISBN: 9780080068626, 9781483159119

Ingredient X

1st Edition

The Production of Effective Drugs

Authors: Louis C. Schroeter
eBook ISBN: 9781483159119
Imprint: Pergamon
Published Date: 1st January 1969
Page Count: 166
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Description

Ingredient X: The Production of Effective Drugs deals with various aspects of pharmaceutical research and development, with emphasis on the importance of formulation ingredients on drug effectiveness and the role of the pharmaceutical development scientist in designing dosage forms for modern drugs. More than 50 illustrations are used to explain experiments and ""tools of the trade"".
This book is comprised of four chapters and opens with an overview of research and development in the pharmaceutical industry, paying particular attention to the kind of work done by scientists according to the degree or level of training. The additives or so-called ""inert"" ingredients used in drug formulation are also considered. The next chapter explains how adding just the right amount of some ""inert"" ingredient—a factor X—can enhance the acceptability of a product to the user. The importance of maintaining drug potency in a dosage form, mainly through refrigeration or storage in cool places, is then discussed. The final chapter looks at the factors to consider to achieve the best possible drug formulation and most effective dosage form, including the safety factor. The need to establish correlations between laboratory quality tests and product performance during the development phase is highlighted. This monograph will be a useful resource for pharmacologists and pharmaceutical development scientists.

Table of Contents


Preface

Chapter I Research and Development (R & D)

Development

Two Kinds of Research

Training

"Inert" Ingredients

Utility

The Big Cake Bake

A Key Factor

Balancing Act

Growing Old

Tactics and Strategy

Chapter II Product Acceptability

From Tinctures to Tablets

Porous Bottles

How Sweet it is or Who Decides the Taste

Almost Everybody Likes Orange

A Panel Decides

Alas, The Color is Gone

Three Dimensions of Color

Squeezing Tubes and Pouring Goo

The Cream "Feels" Good

A Shot in the Arm

Tablets for Chewing and Swallowing

Chapter II On the Shelf

Purity

Activity

Stockpiles and Doctors' Bags

Early Warning System

Mechanisms and Pathways

Air, Air — Everywhere

Oxygen Scavengers

Lights out

Checking Predictions

Cages for Molecules

Layer Cakes

Bugs

Chapter IV Performance

Safety First

Test Tube Tests

Rockets and Tablets

Hostile Environment

Controlling Release

Absorption

Little Pills

Crossover Tests

Radioactive Labels

Activity and Response

What's Available

Placebo Effects and Clinical Tests

Recipe for Quality

Appendix

Glossary

Index

Details

No. of pages:
166
Language:
English
Copyright:
© Pergamon 1969
Published:
Imprint:
Pergamon
eBook ISBN:
9781483159119

About the Author

Louis C. Schroeter