Inflammation in Neuropsychiatric Disorders - 1st Edition - ISBN: 9780123983145, 9780123983206

Inflammation in Neuropsychiatric Disorders, Volume 88

1st Edition

Serial Editors: Rossen Donev
eBook ISBN: 9780123983206
Hardcover ISBN: 9780123983145
Imprint: Academic Press
Published Date: 2nd August 2012
Page Count: 200
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Table of Contents

Chapter One. Inflammation in Anxiety

1 Introduction

2 Cytokines, Brain, and Behavior

3 Inflammation in Anxiety Disorders

4 Inflammation in Anxiety Disorders: Potential Role of Oxidative Stress

5 Oxidative Stress, Transcription Factors, and Inflammation

6 Conclusion

Chapter Two. Inflammation-Related Disorders in the Tryptophan Catabolite Pathway in Depression and Somatization

1 Introduction

2 Tryptophan and the TRYCAT Pathway

3 The TRYCAT Pathway in Somatization

4 Activation of the TRYCAT Pathway May Cause Somatization

5 The TRYCAT Pathway, the CNS, and Somatization

6 Summary

7 Potential Treatment Implications

Chapter Three. Inflammation in Schizophrenia

1 Introduction

2 The Immune Response and the Type-1 and Type-2 Polarization

3 Inflammation in Schizophrenia

4 Type-1 and Type-2 Immune Response in Schizophrenia

5 Antipsychotic Drugs and the Type-1/Type-2 Imbalance in Schizophrenia

6 The Monocyte/Macrophage System in Schizophrenia

7 Brain Imaging and Microglia Activation in Schizophrenia

8 The Tryptophan–Kynurenine Metabolism in Schizophrenia

9 Treatment Options for Schizophrenia Based on Immune Modulation

10 COX-2 Inhibition as Therapeutic Approach in Schizophrenia

Chapter Four. Inflammation in Parkinson’s Disease

1 Introduction

2 Parkinson’s Disease

3 Inflammation in PD

4 Evidence of Inflammation in PD

5 Inflammation in Animal Models of PD

6 Molecular Mechanisms of Inflammation in PD

7 Therapeutic Implications

8 Conclusions

Chapter Five. Treatment with Aβ42 Binding d-Amino Acid Peptides Reduce Amyloid Deposition and Inflammation in APP/PS1 Double Transgenic Mice

1 Introduction

2 Materials and Methods

2.1 Animals

2.2 Peptides

2.3 Hippocampal infusion

2.4 Behavior

2.5 Histopathology


Description

Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics.

Key Features

  • Covers reviews of methodology and research in all aspects of protein chemistry
  • Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics

Readership

Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists


Details

No. of pages:
200
Language:
English
Copyright:
© Academic Press 2012
Published:
Imprint:
Academic Press
eBook ISBN:
9780123983206
Hardcover ISBN:
9780123983145

Reviews

"The authority, originality, and editing of the reviews are first class." --Nature


About the Serial Editors

Rossen Donev Serial Editor

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2010 Dr. Donev was appointed Lecturer in Swansea University. Currently he is Director of Biomed Consult Ltd, UK. His major research interests include signalling pathways involved in neuropsychiatric disorders and tumour escape from the immune system, and development of therapeutic strategies for treatment. He has published more than 50 research papers, has chaired scientific meetings in Molecular Medicine and given plenary talks at Attention Deficit/Hyperactivity Disorder meetings. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals.

Affiliations and Expertise

Swansea University, Swansea, Wales, UK