Inflammation and Obesity

Inflammation and Obesity

A New and Novel Approach to Manage Obesity and its Consequences

1st Edition - September 1, 2022

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  • Editor: Raman Mehrzad
  • Paperback ISBN: 9780323909600

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Description

Inflammation and Obesity: A New and Novel Approach to Manage Obesity and its Consequences is a comprehensive and up-to-date exploration of the correlation between obesity and inflammation. From the pathophysiology of obesity and inflammation, to the molecular mechanisms of obesity induced chronic inflammation, the book discusses how obesity and inflammation interact with other diseases. It highlights the hidden risk factors of obesity induced chronic inflammation, provides specific patient management guidelines regarding the higher inflammatory response in patients, and concludes with new therapeutic strategies to address inflammation in obese patients.

Key Features

  • Identifies the hidden physiological changes that accompany obesity, while also highlighting the challenge of managing obesity with a higher inflammatory response
  • Discusses major hidden health risks of inflammation that accompany obesity, as well as management guidelines for obese patients
  • Links the pathophysiology of inflammation and obesity to the therapeutic strategies that minimizes risk factors, thus opening new areas of research

Readership

Physicians in the field of general surgery, plastic surgery, internal medicine, primary care, endocrinology, rheumatology, obesity medicine, cardiology, gastroenterology, neurology, nutritionists. PhD-students focusing on metabolism, obesity research (huge market) and oncology research in different areas are also primary target markets. Doctors of acupuncture, naturopaths, chiropractors that deal with inflammation and obesity are also a primary target market. Medical students, nurse practitioner and physician assistants in primary care, medical interns, medical residents, medical fellows

Table of Contents


  • 1. Introduction to obesity and inflammation
    a. This will provide an introduction about obesity and inflammation, trend, epidemiology,
    2. The obesity pandemic how we are failing our patients
    a. This will provide important statistics and information about the global pandemic of obesity and explain the meteoric rise in the incidence of obesity and the role of the modern clinician in facilitating it
    3. Inflammation - a multifaceted and omnipresent phenomenon
    a. Basic mechanism, underlying induction, progression and resolution of chronic inflammation
    b. The cellular component of chronic inflammation: monocytes, macrophages, neutrophils, dendritic cells, fibrocytes, T-cells
    c. Gut mediated inflammation
    d. Stealth pathogens
    e. An explanation of the various etiologies of chronic inflammation that explain its ubiquitous presence in our patients
    f. Metabolic syndrome
    4. Pathophysiology of Obesity
    a. Adipocyte transformation
    b. Phenotype of obesity
    c. Endocrine action of Adipocytes
    i. Cytokines
    1. Insulin resistance
    2. Auto-immunity
    ii. Sex Hormone dysregulation
    d. Ectopic fat depots
    e. Epigenetics mechanisms and miRNA
    - A summary of the scientific evidence showing the many pathophysiologic changes occurring within our obese patients often resulting in a self-propagating clinical state that resists traditional management techniques
    5. Consequences of obesity
    a. This will provide the important consequences of obesity in each organ, their pathophysiology and why they lead to health issues.
    6. Consequences of inflammation
    a. This will provide the important consequences of inflammation in different organs, their pathophysiology and why they lead to health issues.
    7. Inflammation and Obesity
    a. Epidemiology
    b. What the numbers say about chronic obesity and inflammation and where it is headed
    c. Physiology of obesity and inflammation
    d. Molecular mechanisms underlying obesity induced chronic inflammation
    8. Obesity, inflammation and autoimmune disease
    a. This provides important and new scientific based research establishing the connection between obesity, inflammation and its risk for autoimmune disorders
    9. Obesity, inflammation and aging
    a. This provides important and new scientific based research establishing the connection between obesity, inflammation and its risk aging
    10. Obesity, inflammation and diseases of the gastrointestinal tract
    a. This provides important and new scientific based research establishing the connection between obesity, inflammation and its risk for diseases of the gastrointestinal tract
    11. Obesity, inflammation and cardiovascular disorders
    a. This provides important and new scientific based research establishing the connection between obesity, inflammation and its risk for cardiovascular disorders
    12. Obesity, inflammation and cancer
    a. This provides important and new scientific based research establishing the connection between obesity, inflammation and its risk for cancer
    13. Obesity, inflammation and diseases of the central nervous system
    a. This provides important and new scientific based research establishing the connection between obesity, inflammation and its risk for diseases of the central nervous system
    14. Resolution of inflammation
    a. This s provide new scientific based knowledge about how inflammation is resolved: macrophage phenotyope, dead cell clearance, lipid mediators such as lipotoxins, cyclopenetone prostaglandins, resolving and protectins, maresins
    b. Role of microRNAs in inflammation
    c. Linking MicroRNA and lipid mediators, in resolution of inflammation
    15. Physical activity in obesity and inflammation prevention and management
    a. This s provide new scientific based knowledge about the role of physical activity in the management and prevention of obesity related inflammation
    16. Diet in obesity and inflammation prevention and management
    a. This s provide new scientific based knowledge about the role of diet, anti-inflammatory nutritional and herbal medicines in the management and prevention of obesity related inflammation
    17. Management of Obesity- related inflammatory disorders
    a. Why we need to add new strategies beyond calorie counting and exercise
    b. Addressing Obesity related inflammation
    c. A stepwise approach and system for managing these patients
    d. Lowering risk of morbidity in the chronically obese
    e. Laboratory testing
    f. New therapeutic strategies to address inflammation in obese patient
    - Real time practical strategies evaluate status of the obese patient (beyond a simple weigh in) and subsequent strategies to lower long term risk of disease and start the road to recovery

Product details

  • No. of pages: 400
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: September 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323909600

About the Editor

Raman Mehrzad

Dr. Mehrzad is a physician, scientist and author who has worked closely with attendings and hundreds of students, interns, residents and fellows throughout his career. He is American Board Certified in Internal medicine and worked as a specialized physician at Yale New Haven Hospital for 3 years where he was also a clinical instructor at Yale School of Medicine. Currently, he is pursuing a Plastic & Reconstructive Surgery residency at Rhode Island Hospital, Brown University and hence with his background brings both medical and surgical knowledge to the project. Dr. Mehrzad has conducted extensive scientific research in multiple areas in medicine, surgery and education and has over 36 peer-reviewed articles and over 22 abstracts published. He has written 5 books that are selling widely in Sweden, Denmark, Austria, Germany and Switzerland, and contributed to six 6 medical and surgical textbooks. He is also an international lecturer and has lectured at over 100 schools for thousands of students across Europe. Lastly, beside his medical degree, Dr. Mehrzad holds an Executive Master of Healthcare Leadership degree from Brown University and a Master of Business Administration degree from University of Massachusetts, Isenberg school of Business.

Affiliations and Expertise

Division of Plastic and Reconstructive Surgery, Rhode Island Hospital, The Warren Alpert School of Brown University, Providence, RI, United States

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