Inflammation and Obesity

1. Introduction to obesity and inflammation
a. This will provide an introduction about obesity and inflammation, trend, epidemiology,

2. The obesity pandemic how we are failing our patients
a. This will provide important statistics and information about the global pandemic of obesity and explain the meteoric rise in the incidence of obesity and the role of the modern clinician in facilitating it

3. Inflammation - a multifaceted and omnipresent phenomenon
a. Basic mechanism, underlying induction, progression and resolution of chronic inflammation
b. The cellular component of chronic inflammation: monocytes, macrophages, neutrophils, dendritic cells, fibrocytes, T-cells
c. Gut mediated inflammation
d. Stealth pathogens
e. An explanation of the various etiologies of chronic inflammation that explain its ubiquitous presence in our patients
f. Metabolic syndrome

4. Pathophysiology of Obesity
a. Adipocyte transformation
b. Phenotype of obesity
c. Endocrine action of Adipocytes
i. Cytokines

1. Insulin resistance

2. Auto-immunity
ii. Sex Hormone dysregulation
d. Ectopic fat depots
e. Epigenetics mechanisms and miRNA
- A summary of the scientific evidence showing the many pathophysiologic changes occurring within our obese patients often resulting in a self-propagating clinical state that resists traditional management techniques

5. Consequences of obesity
a. This will provide the important consequences of obesity in each organ, their pathophysiology and why they lead to health issues.

6. Consequences of inflammation
a. This will provide the important consequences of inflammation in different organs, their pathophysiology and why they lead to health issues.

7. Inflammation and Obesity
a. Epidemiology
b. What the numbers say about chronic obesity and inflammation and where it is headed
c. Physiology of obesity and inflammation
d. Molecular mechanisms underlying obesity induced chronic inflammation

8. Obesity, inflammation and autoimmune disease
a. This provides important and new scientific based research establishing the connection between obesity, inflammation and its risk for autoimmune disorders

9. Obesity, inflammation and aging
a. This provides important and new scientific based research establishing the connection between obesity, inflammation and its risk aging

10. Obesity, inflammation and diseases of the gastrointestinal tract
a. This provides important and new scientific based research establishing the connection between obesity, inflammation and its risk for diseases of the gastrointestinal tract

11. Obesity, inflammation and cardiovascular disorders
a. This provides important and new scientific based research establishing the connection between obesity, inflammation and its risk for cardiovascular disorders

12. Obesity, inflammation and cancer
a. This provides important and new scientific based research establishing the connection between obesity, inflammation and its risk for cancer

13. Obesity, inflammation and diseases of the central nervous system
a. This provides important and new scientific based research establishing the connection between obesity, inflammation and its risk for diseases of the central nervous system

14. Resolution of inflammation
a. This s provide new scientific based knowledge about how inflammation is resolved: macrophage phenotyope, dead cell clearance, lipid mediators such as lipotoxins, cyclopenetone prostaglandins, resolving and protectins, maresins
b. Role of microRNAs in inflammation
c. Linking MicroRNA and lipid mediators, in resolution of inflammation

15. Physical activity in obesity and inflammation prevention and management
a. This s provide new scientific based knowledge about the role of physical activity in the management and prevention of obesity related inflammation

16. Diet in obesity and inflammation prevention and management
a. This s provide new scientific based knowledge about the role of diet, anti-inflammatory nutritional and herbal medicines in the management and prevention of obesity related inflammation

17. Management of Obesity- related inflammatory disorders
a. Why we need to add new strategies beyond calorie counting and exercise
b. Addressing Obesity related inflammation
c. A stepwise approach and system for managing these patients
d. Lowering risk of morbidity in the chronically obese
e. Laboratory testing
f. New therapeutic strategies to address inflammation in obese patient
- Real time practical strategies evaluate status of the obese patient (beyond a simple weigh in) and subsequent strategies to lower long term risk of disease and start the road to recovery