Inflammation and Natural Products

1st Edition - January 19, 2021
Editors: Sreeraj Gopi, Augustine Amalraj, Ajaikumar B. Kunnumakkara, Sabu Thomas
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 1 9 2 1 8 - 4
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 9 2 1 9 - 1

Inflammation and Natural Products brings together research in the area of the natural products and their anti-inflammatory action in medical, nutraceutical and food products,… Read more

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Inflammation and Natural Products brings together research in the area of the natural products and their anti-inflammatory action in medical, nutraceutical and food products, addressing specific chronic inflammatory diseases like cancer and the mechanistic aspects of the mode of action of some key natural products. Inflammation is a complicated process, driven by infection or injury or genetic changes, which results in triggering signalling cascades, activation of transcription factors, gene expression, increased levels of inflammatory enzymes, and release of various oxidants and pro-inflammatory molecules in inflammatory cells. Excessive oxidants and inflammatory mediators have a harmful effect on normal tissue, including toxicity, loss of barrier function, abnormal cell proliferation, inhibiting normal function of tissues and organs and finally leading to systemic disorders. The emerging development of natural product formulations utilizing the unique anti-inflammatory compounds such as polyphenols, polysaccharides, terpenes, fatty acids, proteins and several other bioactive components has shown notable successes. Inflammation and Natural Products: Recent Development and Current Status provides a comprehensive resource, ranging from detailed explanation on inflammation to molecular docking strategies for naturally occurring compounds with anti-inflammatory activity. It is useful for graduate students, academic and professionals in the fields of pharmaceutical and medical sciences and specialists from natural product-related industries.

Cover image
Title page
Table of Contents
Copyright
Contributors
1 Inflammation, symptoms, benefits, reaction, and biochemistry
Abstract
1.1 Introduction
1.2 Causes and symptoms of inflammation
1.3 Types of inflammation
1.4 Benefits of inflammation
1.5 Reactions and biochemistry
1.6 Conclusion
References
2 Natural products with antiinflammatory activities against autoimmune myocarditis
Abstract
2.1 Introduction
2.2 Myocarditis
2.3 Etiology and pathogenesis of autoimmune myocarditis
2.4 Antiinflammatory mechanism for autoimmune myocarditis
2.5 Natural products renowned for antiinflammatory activity
2.6 Conclusion
References
3 Multitarget approach for natural products in inflammation
Abstract
3.1 Introduction
3.2 Mechanisms: Mediators and pathways behind inflammation
3.3 Distinct pathways behind neuroinflammation; Alzheimer’s disease as a case
3.4 Multitarget approach for antiinflammatory action
3.5 Natural compounds with multitarget in antiinflammation
3.6 Combination of phytochemicals
3.7 Conclusion
References
4 Antiinflammatory activity of natural dietary flavonoids
Abstract
4.1 Introduction
4.2 Flavonoids and cardiovascular diseases
4.3 Flavonoids and diabetes mellitus
4.4 Flavonoids and gastrointestinal diseases
4.5 Conclusion and perspectives
References
5 Antiinflammatory effects of turmeric (Curcuma longa) and ginger (Zingiber officinale)
Abstract
5.1 Introduction
5.2 Turmeric
5.3 Ginger (Zingiber officinale)
5.4 Conclusion
References
6 Antiinflammatory activity of Boswellia
Abstract
6.1 Introduction
6.2 Taxonomy and phytochemistry
6.3 Pharmacological activities of Boswellia
6.4 Preclinical studies
6.5 Clinical studies of the antiinflammatory action
6.6 Toxicity and side effects in clinical evaluations
6.7 Conclusion
References
7 Antiinflammatory activity of galangal
Abstract
7.1 Introduction
7.2 Phytochemistry
7.3 Mechanism of antiinflammatory pathway
7.4 Pharmacological activities
7.5 Usage in traditional systems
7.6 Toxicity studies
7.7 Conclusion
References
8 Antiinflammatory natural products from marine algae
Abstract
8.1 Introduction
8.2 Inflammation
8.3 Algal natural products with antiinflammatory activity
8.4 Conclusions
Conflict of interest
References
9 Medicinal plants and their potential use in the treatment of rheumatic diseases
Abstract
9.1 Introduction
9.2 Herbal products currently used in antiarthritic therapy
9.3 Conclusion and perspectives
References
10 Natural product–derived drugs for the treatment of inflammatory bowel diseases (IBD)
Abstract
10.1 Introduction
10.2 Epidemiology
10.3 Pathogenesis
10.4 The role of natural products on IBD
10.5 Natural products for ulcerative colitis and Crohn’s disease
10.6 Conclusion remarks and future perspective
References
11 Smart drug delivery systems of natural products for inflammation: From fundamentals to the clinic
Abstract
11.1 Introduction
11.2 Stimuli-responsive drug delivery system
11.3 Conclusion
References
12 Systems pharmacology and molecular docking strategies prioritize natural molecules as antiinflammatory agents
Abstract
12.1 Introduction
12.2 Systems pharmacology and antiinflammatory agents
12.3 Computational methodologies and molecular docking studies with natural compounds
12.4 Inflammatory pathway network and key node targets of antiinflammatory agents
12.5 Prioritization strategy and systems pharmacology approach for screening of potential therapeutic agents
12.6 Natural compounds and their interactions in the inflammatory pathway network and prioritization as antiinflammatory agents
12.7 Conclusion
References
13 Bioavailability, pharmacokinetic, pharmacodynamic, and clinical studies of natural products on their antiinflammatory activities
Abstract
13.1 Introduction
13.2 Antiinflammatory activities of natural products
13.3 Conclusion
References
14 Supplements and diets for antiinflammation
Abstract
14.1 Introduction
14.2 Types of inflammatory
14.3 Antiinflammatory supplements
14.4 Role of diet in body inflammation
14.5 Nutrient effects on chronic inflammation
14.6 Conclusion
References
15 Values of natural products to future antiinflammatory pharmaceutical discovery
Abstract
15.1 Introduction
15.2 Inflammatory mediators
15.3 Antiinflammatory therapy and response
15.4 Nonsteroidal antiinflammatory drugs vs inflammation
15.5 Biodiversity of plant natural products
15.6 Medicinal plants as gift of nature
15.7 Herbal remedies in traditional medication for inflammation
15.8 Ayurvedic formulation for inflammation
15.9 Natural products—A promising antiinflammatory pharmaceutical drug discovery
15.10 Major challenges in upgrading natural products
15.11 Future prospective and conclusions
References
16 Identification of toxicology biomarker and evaluation of toxicity of natural products by metabolomic applications
Abstract
16.1 Background
16.2 Metabolomic technology
16.3 Sample preparation
16.4 Data analysis
16.5 Metabolomics in toxicity evaluation and biomarker identification of natural products
16.6 Concluding remarks and perspectives
References
Index

Sreeraj Gopi

Dr. Sreeraj Gopi is the Co-Founder and Director of Molecules Food solutions Pvt Ltd, Zingon Naturals Pvt Ltd. He was the Chief Scientist at Plant Lipids Pvt Ltd. and Chief Scientific Officer at Aurea Biolabs Pvt Ltd., He has also served as an adjunct professor at universities including Stockholm University, Sweden, Siberian Federal University, Russia, and Mahatma Gandhi University, India. He completed his doctorate in organic chemistry and nanotechnology, and nano drug delivery working in the area of natural products, isolation, and biological activities. He published more than 175 international articles and filed more than 75 patents, in the US and Europe. At Plant Lipids, he developed many innovative products and technologies, and is responsible for driving the research team to excellence, as well as, implementing new projects, presenting scientific seminars to various customers. He was listed world's top 2% scientist list by Standford University.

Affiliations and expertise

Co-Founder and Director of Molecules Food solutions Pvt Ltd, Zingon Naturals Pvt Ltd.

Augustine Amalraj

Dr. Augustine Amalraj is currently working as a Senior Scientist in the Department of Research and Development at Molecules Food Solutions Private Limited, Koratty, Thrissur, Kerala, India. He was worked as a Deputy Manager in the Department of Research and Development at Plant Lipids Private Limited and Aurea Biolabs Private Limited, Cochin, India. He obtained his Doctoral degree in Chemistry from Gandhigram Rural Institute – Deemed University, Gandhigram, Tamil Nadu, India. His research interests are in applied chemistry, food chemistry, natural product chemistry, environmental chemistry, chemosensors, and polymer and nanocomposite materials. He has published more than 60 research articles in international journals, as well as 22 book chapters, co-edited 10 books and filed 3 patents. He was listed among the top 2% of scientists in the world by Stanford University.

Affiliations and expertise

Molecules Food Solutions Private Limited

Ajaikumar B. Kunnumakkara

Prof. Ajaikumar Kunnumakkara, is a faculty member in the Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, India. He is also an Honorary Chair Professor in Nanoscience and Nanotechnology. He is the principal investigator of Unit of Excellence in cancer drug discovery (DBT, Govt. of India) and the coordinator of DBT (India) - AIST (Japan) International Laboratory for Advanced Biomedicine. He earned his doctorate in 2006 from Amala Cancer Research Center, Thrissur, affiliated with University of Calicut, Kerala, India. Dr. Kunnumakkara did postdoctoral work at the University of Texas MD Anderson Cancer Center, Houston, Texas, USA (2005–2008) and the National Cancer Institute of National Institutes of Health (2008–2010) where he was subsequently employed as an NIH Scientist until 2012. Dr. Kunnumakkara has also edited four monographs. He is an elected Fellow of Royal Society of Medicine, UK as well as belonging to many other esteemed institutions.

Affiliations and expertise

Indian Institute of Technology Guwahati, India

Sabu Thomas

Dr. Thomas is the Vice-Chancellor and a Professor of Polymer Science and Engineering at Mahatma Gandhi University, India. Additionally, he serves as the Director of the School of Energy Materials at the same institution. Dr. Thomas is internationally recognized for his contributions to polymer science and engineering, covering polymer nanocomposites, elastomers, polymer blends, interpenetrating polymer networks, polymer membranes, green composites, nanocomposites, nanomedicine, and green nanotechnology. His groundbreaking inventions in polymer nanocomposites, polymer blends, green bionanotechnological, and nano-biomedical sciences have significantly contributed to the development of new materials in the automotive, space, housing, and biomedical fields. Dr. Thomas has been conferred with Honoris Causa (DSc) by the University of South Brittany, Lorient, France.

Affiliations and expertise

Vice-chancellor, Mahatma Gandhi University, India