Inflammation, Advancing Age and Nutrition

Inflammation, Advancing Age and Nutrition

Research and Clinical Interventions

1st Edition - September 3, 2013

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  • Editors: Irfan Rahman, Debasis Bagchi
  • eBook ISBN: 9780123978073

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Description

The book provides a comprehensive overview to understanding the integrated impact of the concepts of cellular and molecular aspects, models, environmental factors, and lifestyle involved in premature aging. Additionally, it examines how functional food, dietary nutraceuticals or pharmacological compounds can reverse inflammation and premature aging based on personalized medicine. This book is a valuable resource for health professionals, scientists and researchers, nutritionists, health practitioners, students and for all those who wish to broaden their knowledge in the allied field.

Key Features

  • Includes models of aging, including worm, mouse and human
  • Explores the relationship of inflammation with diseases, including ocular health, Alzheimer's and Parkinson's disease, and muscle health
  • Encompasses a variety of lifestyle impacts, including diet, exercise and nutrition
  • Includes suggested nutritional interventions

Readership

Researchers, scientists and physicians specializing in arthritis, obesity, diabetes, hypertension, osteoporosis and osteoarthritis, and cardiovascular fields. Gerontologists and Geriatricians. Nutritionists and Dieticians.

Table of Contents

  • Dedication

    Biography

    Preface

    Contributors

    Chapter 1. Biomarkers and Inflammatory Network in Aging: Targets for Therapies

    Abstract

    Introduction

    Aging Biomarkers: Definition and Selection Criteria

    Inflammatory Network: A Description and its Biological Effects on Aging

    Cellular Inflammatory Biomarkers

    Serum Inflammatory Biomarkers

    Molecules and Mechanisms Linked to THE NF-κB Signaling System are Potential Targets for Anti-Aging and Anti-Age-Related Disease Treatment Strategies

    Conclusions

    References

    Chapter 2. The Biological Significance of Zinc in Inflammation and Aging

    Abstract

    Acknowledgments

    Introduction

    Inflammation, Cellular and Tissue Damage, and Chronic Disease

    Reactive Oxygen Species and their Physiological Roles

    Reactive Oxygen Species and Cell or Tissue Injury

    The Biology of Aging

    Aging, Inflammation, Oxidative Stress, and Dna Damage

    The Biological Functions of Zinc

    The Role of Zinc as an Anti-Inflammatory Agent

    Zinc as an Antioxidant Agent

    The Molecular Link Between NF-κB, A20, Zinc, And Cancer

    The Role of Zinc in The Regulation of Nrf2, Aging, and Cancer

    The Role of Zinc in the Regulation of p53 and Cancer

    Conclusions and Perspectives

    References

    Chapter 3. Immunity, Inflammation, and Aging

    Abstract

    Introduction

    Aging and Immune System Remodeling

    Aging and Inflammation

    Summary and Conclusions

    References

    Chapter 4. Oxidative Stress, Inflammaging, and Immunosenescence

    Abstract

    Introduction

    Inflammaging

    Roles of Oxidative and Inflammatory Stress in Immunosenescence

    The Oxidation-Inflammation Theory of Aging

    Role of Antioxidants in the Immune System

    Chronic Stress Leads to Premature Immunosenescence and Increased Inflammaging

    Conclusions

    References

    Chapter 5. Stress Response, Inflammaging, and Cancer

    Abstract

    Introduction

    Inflammation and Cancer

    Inflammaging in Carcinogenesis

    Phytochemicals as Chemopreventive Agents

    References

    Chapter 6. Aging, Immunosenescence, and Cancer

    Abstract

    Acknowledgments

    Introduction

    The Definition of Aging

    Aging and Cancer

    Immune System and Cancer

    Immunosenescence and Inflammaging

    Immunosenescence and Cancer

    Modulation

    Conclusions

    References

    Chapter 7. Telomere Biology in Senescence and Aging: Focus on Cardiovascular Traits

    Abstract

    Acknowledgments

    Introduction

    Telomere Biology and Its Link to Cellular Senescence

    Telomere/Telomerase and Aging

    The Axis of Aging: Telomere-P53-Mitochondria

    Factors Influencing Telomere Length

    Factors Influencing Telomerase

    Telomere Biology in Stem Cells

    Telomere Biology and Cardiovascular Traits

    Telomere Biology and Diabetes

    Perspectives

    References

    Chapter 8. Epigenetics, Inflammation, and Aging

    Abstract

    Introduction

    Epigenetics and the Fetal Origin of Adult Diseases

    Mechanisms Involved in Dietary and Nutritional Modulation of DNA Methylation and Histone Modifications

    Dietary Influence on Epigenetics During Early Development

    Influence of Dietary Components on Epigenetic Marks in Developed Organisms

    Epigenetic Changes to the Immune System that Lead to Inflammation and Disease

    Conclusions

    References

    Chapter 9. Nutrition as an Epigenetic Modifier in Aging and Autoimmunity

    Abstract

    Introduction

    Epigenetics and Aging

    Environmental Stressors, Epigenetics, and Autoimmunity

    Epigenetics in Different Autoimmune Diseases

    Diet, DNA Methylation, and Immune-Mediated Diseases

    Lifetime Diet

    Conclusions

    References

    Chapter 10. Connecting Phytochemicals, Epigenetics, and Healthy Aging: Is Metabolism the Missing Link?

    Abstract

    Acknowledgments

    Introduction

    Crosstalk of Inflammation and Energy Metabolism Fuel Epigenetic Plasticity

    Nutriepigenomics: Lifelong Remodeling of Our Epigenomes By Nutritional, Phytochemical, and Metabolic Factors

    Xenohormetic Epigenetic Effects of Plant Secondary Metabolites Across Species: An Evolutionary Role for Stress Adaptive Responses in Healthy Aging and Longevity

    Conclusion

    References

    Chapter 11. Diet/Nutrition, Inflammation, Cellular Senescence, Stem Cells, Diseases of Aging, and Aging

    Abstract

    Introduction: The Effect of Evolution of the Physical World on the Evolution of the Biological World

    Evolutionary Transition from an Anoxic Environment to an Aerobic Environment: Mitochondria, Asymmetric Cell Division, Stem Cells, and Metazoans

    Aging of the Organism

    How the Study of Human Carcinogenesis Might Assist in Unraveling Aging: The Role of Stem Cells, Cell-Cell Communication, Diet, and Inflammation in the Multistage, Multi-Mechanism Process of Carcinogenesis

    What is the Origin of the Initiated Cell?

    Role of Oxygen in the Homeostatic Regulation of Stem Cells

    Stem Cells, The Warburg Hypothesis, and Cancer

    Roles of Nutrition/Diet and Inflammation in the Different Phases of Carcinogenesis

    Stem Cells and Aging

    Cellular Senescence: The End of Cellular Life Span or Only a Reversible, Transient Epigenetic Quiescent Stage of the Cell’s Life?

    Summary

    References

    Chapter 12. Circadian Clock Mechanisms Link Aging and Inflammation

    Abstract

    Introduction

    The Circadian System and Rhythms

    Molecular Mechanisms of the Circadian Clock

    Circadian Clock Disruption and Aging

    Mechanisms of the Circadian Clock and Aging

    Circadian Clock and Inflammation

    Conclusions and Perspectives

    References

    Chapter 13. Obesity, Insulin Resistance, and Inflammaging

    Abstract

    Abbreviations

    Introduction

    Inflammatory Mediators, Obesity, and Aging

    CrossTalk between Insulin and Inflammatory Signaling

    Adipose Tissue Macrophages

    Role of Other Immune Cell Types in Obesity-Associated Inflammaging

    Therapeutic Options

    Conclusion

    References

    Chapter 14. Organelle Stress and mTOR in Aging-Associated Inflammation

    Abstract

    Abbreviations

    Introduction

    Turning Cellular Stress into Inflammation: Endoplasmic Reticulum and Mitochondria

    mTOR in Nutrient Sensing and Aging

    mTOR Routes to Inflammation

    mTOR, Inflammation, and “Hypertrophic” Aging

    mTOR and Cellular Senescence

    mTOR and Stem Cell Aging

    mTOR, Obesity, and “Metainflammation”

    Hypertrophy Versus Atrophy, mTOR, and Muscle Aging

    Concluding Remarks: Aging and mTOR-Dependent Repair

    References

    Chapter 15. SIRT1 and Inflammaging in Chronic Obstructive Pulmonary Disease

    Abstract

    Acknowledgments and Disclosures

    Introduction

    Inflammaging in COPD

    Abnormal Cellular Processes During Inflammaging in COPD

    SIRT1 and Inflammaging

    SIRT1 Agonists/Activators: Anti-Inflammaging Molecules

    Conclusions

    References

    Chapter 16. Stress-Induced Premature Senescence: Another Mechanism Involved in the Process of Accelerated Aging in Chronic Obstructive Pulmonary Disease

    Abstract

    Introduction

    Inflammaging and Cellular Senescence: Basic Characteristics

    Inflammaging and Oxidative Stress in COPD

    Stress-Induced Premature Senescence Under Oxidative Stress in COPD

    Functions of Stress-Induced Premature Senescence Overlap with Inflammaging in COPD

    COPD in a Human Model with Prematrue Aging Features Related to Inflammaging or Stress-Induced Premature Senescence

    Role of Inflammaging in Extrapulmonary Manifestations of COPD

    Unresolved Questions

    References

    Chapter 17. Cellular Senescence and Premature Aging in Lung Diseases

    Abstract

    Why Do Senescence- and Elderly-Specific Diseases Develop?

    Cellular Senescence Associated with Aging and Illness Often Seen in Elderly People

    COPD

    Pulmonary Fibrosis

    Differences in the Cellular Senescence Underlying the Onset of Pulmonary Emphysema and Fibrosis

    Conclusions

    References

    Chapter 18. Rheumatoid Arthritis: Disease Pathophysiology

    Abstract

    Abbreviations

    Introduction

    T Cells in Rheumatoid Arthritis

    B Cells and Autoantibodies

    Cytokines in Rheumatoid Arthritis

    Cartilage/Bone Destruction

    Conclusions

    References

    Chapter 19. Aging and Anti-Aging in Hair and Hair Loss

    Abstract

    Introduction

    Mechanisms in the Aging of Hair Follicles

    Chronic Inflammation in the Pathogenesis of Hair Diseases

    Anti-Aging

    Conclusion

    References

    Chapter 20. Muscle Wasting, Dysfunction, and Inflammaging

    Abstract

    Introduction

    Age-Related Changes in Skeletal Muscle

    Disability Threshold

    Causes of Age-Related Muscle Dysfunction

    Exercise

    Conclusion

    References

    Chapter 21. Matrix Metalloproteinases and Skin Inflammaging

    Abstract

    Introduction

    Matrix Metalloproteinases and Skin-Intrinsic Aging

    Matrix Metalloproteinases and Skin Photoaging

    Matrix-Directed Skin Inflammaging

    Concluding Remarks: Skin Inflammaging Proteases and Cutaneous Disorders in Elderly Persons

    References

    Chapter 22. Ocular Health, Vision, and a Healthy Diet

    Abstract

    Introduction

    Ocular Inflammatory Diseases

    Age-Related Ocular Diseases

    Management of Ocular Diseases to Promote Healthy Vision

    Conclusions and Perspectives

    References

    Chapter 23. The Role of Physical Activity in Healthy Living: Its Anti-Inflammatory Effects

    Abstract

    Introduction

    Daily Physical Activity Recommendations

    Overweight and Obesity

    Type 2 Diabetes

    Metabolic Syndrome

    Hypertension

    Hyperlipidemia

    Inflammation

    Review of the Evidence on the Effect of Exercise on Inflammatory Markers

    References

    Chapter 24. Erectile Dysfunction in Inflammaging

    Abstract

    Introduction

    Prevalence and Etiology

    Pathophysiology of Erectile Dysfunction in the Aging Man

    Assessment

    Treatment

    Conclusions

    References

    Chapter 25. Role of Saturated and Polyunsaturated Fat in Obesity-Related Inflammation

    Abstract

    Introduction

    Intracellular Fatty Acid Metabolism

    Polyunsaturated Fatty Acids as Precursors of Pro- and Anti-Inflammatory Mediators

    The Cellular and Molecular Basis of Inflammation

    Mechanisms of Obesity-Related Low-Grade Inflammation

    Role of Different Fatty Acid Types on Low-Grade Inflammation

    Concluding remarks

    References

    Chapter 26. Cellular Stress Response, Hormesis, and Vitagens in Aging and Longevity: Role of mitochondrial “Chi”

    Abstract

    Acknowledgments

    Introduction

    Cellular Stress Response, Heat Shock Transcription Factor Biology, and the Vitagene Network

    The Mitochondrial Theory of Aging

    Hormesis

    Conclusions and Future Directions

    References

    Chapter 27. Inflammaging Signaling in Health Span and Life Span Regulation: Next Generation Targets for Longevity

    Abstract

    Acknowledgments

    Introduction

    Inflammaging

    Signaling Network Controlling the Aging Process

    Dietary Restriction and Extension of Life Span

    Potential Targets for Anti-Aging Medicine

    Magic Bullets Without Potency

    Conclusions

    References

    Chapter 28. Trophokines: Novel Therapy for Senescence-Related Fibrosis

    Abstract

    Introduction

    Potential Clinical Applications of Trophokines

    Preclinical Progress with Therapeutic Trophokines

    Summary: HGF-FC/MSP-FC Fusion Provides a Possible New Therapeutic Antifibrotic Agent

    References

    Chapter 29. Frailty: A Basic and Clinical Challenge for the Future

    Abstract

    Introduction

    Challenges Raised by Frailty

    References

    Index

Product details

  • No. of pages: 394
  • Language: English
  • Copyright: © Academic Press 2013
  • Published: September 3, 2013
  • Imprint: Academic Press
  • eBook ISBN: 9780123978073

About the Editors

Irfan Rahman

Debasis Bagchi

Debasis Bagchi
Debasis Bagchi, PhD, MACN, CNS, MAIChE, received his Ph.D. in Medicinal Chemistry in 1982. He is a Professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy, Houston, TX, and Chief Scientific Officer at Cepham Research Center, Piscataway, NJ, Adjunct Faculty in Texas Southern University, Houston, TX. He served as the Senior Vice President of Research & Development of InterHealth Nutraceuticals Inc, Benicia, CA, from 1998 until Feb 2011, and then as Director of Innovation and Clinical Affairs, of Iovate Health Sciences, Oakville, ON, until June 2013. Dr. Bagchi received the Master of American College of Nutrition Award in October 2010. He is the Past Chairman of International Society of Nutraceuticals and Functional Foods (ISNFF), Past President of American College of Nutrition, Clearwater, FL, and Past Chair of the Nutraceuticals and Functional Foods Division of Institute of Food Technologists (IFT), Chicago, IL. He is serving as a Distinguished Advisor on the Japanese Institute for Health Food Standards (JIHFS), Tokyo, Japan. Dr. Bagchi is a Member of the Study Section and Peer Review Committee of the National Institutes of Health (NIH), Bethesda, MD. He has published 321 papers in peer reviewed journals, 30 books, and 18 patents. Dr. Bagchi is also a Member of the Society of Toxicology, Member of the New York Academy of Sciences, Fellow of the Nutrition Research Academy, and Member of the TCE stakeholder Committee of the Wright Patterson Air Force Base, OH. He is also Associate Editor for the Journal of Functional Foods, Journal of the American College of Nutrition, and the Archives of Medical and Biomedical Research, and is also serving as Editorial Board Member of numerous peer reviewed journals, including Antioxidants & Redox Signaling, Cancer Letters, Toxicology Mechanisms and Methods, and The Original Internist, among others.

Affiliations and Expertise

Professor, Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, USA; Chief Scientific Officer, Cepham Research Center, Piscataway, New Jersey; Adjunct Faculty, Texas Southern University, Houston, Texas, USA

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