Industrial Process Scale-up

Industrial Process Scale-up

A Practical Innovation Guide from Idea to Commercial Implementation

1st Edition - April 25, 2013

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  • Author: Jan Harmsen
  • eBook ISBN: 9780444627391

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This book will help industrial process innovators in research, development and commercial start-up to assess the risks of commercial-scale implementation and provide them with practical guidelines and methods to reduce the risks to acceptable levels. The book can also be used in co-operation with industrial R&D people and academic researchers to shape open innovation programs and in education as a reference book for process innovation courses.

Key Features

  • Offers easily accessible, step-by-step, and concise guidelines for industrial process scale-up
  • Explains each stage of the innovation funnel: research, development, demonstration, commercial implementation for any process type and branch
  • Based on industrial experiences and practices, which reduces the risks of commercial scale implementation of new processes to acceptable levels and reduces cost and time of process innovation
  • Very clear, attractive layout, using text boxes that contain clarifying notes and additional information on specific topics, which makes it a quick reference of main subjects and additional information


Engineering students, researchers in chemical engineering, process developers, process designers, and R&D managers in process industries for Oil & Gas, Bulk/Fine Chemicals, Biotechnology, Biomass conversion, Ore processing, Metals, Food and Pharmaceuticals

Table of Contents

  • Dedication



    Chapter 1. Introduction

    1.1 Purpose of the Book

    1.2 Scale-Up Definition

    1.3 Scale-Up Methodology

    1.4 Content Structure of the Book

    Chapter 2. Process Industries Characteristics

    2.1 Industrial Players and Partners

    2.2 Supply and Value Chains

    2.3 Industrial Complexes

    2.4 Processes

    2.5 Unit Operations

    2.6 Major Process Equipment

    2.7 Transfer Phenomena

    2.8 Chemistry and Catalysis

    2.9 Types of Design in Innovation

    Chapter 3. Ideation and Research Stages

    3.1 Ideation Stage

    3.2 Research Stage

    Chapter 4. Development Stage

    4.1 Mini-Plant Objectives and Design

    4.2 Pilot Plant Objectives and Design

    4.3 Cold-Flow Plant Objectives and Design

    4.4 Commercial Scale Process Design in Development Stage

    4.5 Development Gate Decision

    Chapter 5. Demonstration Stage

    5.1 Rationale Demonstration Scale Process

    5.2 Execution Demonstration Stage

    Chapter 6. Start-Up Commercial Processes

    6.1 Start-Up Time Prediction

    6.2 Start-Up Organisation

    6.3 Post-Start-Up Reporting

    Chapter 7. Scale-Up of Unit Operations

    7.1 Critical Success Factors for Unit Operations and Equipment

    7.2 Scale-Up Methods for Unit Operations

    7.3 Scale-Up of Most Used Unit Operations

    Chapter 8. A Risk-Based Approach to Scale-Up of Amine Absorption Processes for CO2 Capture and Storage

    8.1 Introduction

    8.2 Scale-Up of Amine Absorption Processes for CCS

    8.3 Risk-Based Approach to Scale Up of Amine Absorption Processes for CCS

    8.4 Case Study: Applications of the DNV Method to Current Industrial Challenges

    8.5 TQ and Process Development (Scale-Up) Stages

    8.6 Summary


    Chapter 9. Industrial Scale-Up Cases

    9.1 Liquid–Liquid Extractive Reaction Case

    9.2 Bulk Chemical Product Start-Up Conventional Process

    9.3 Start-Up Conventional Process in South Korea

    9.4 Case Purchasing Novel Process

    9.5 Polymerisation Process Start-Up

    9.6 Styrene Monomer Propylene Oxide Wastewater Novel Design and Implementation

    9.7 Carilon Engineering Polymer Case

    9.8 Purchasing a Commercially Proven Rotating Filter

    9.9 Fermentation Scale-Up


Product details

  • No. of pages: 112
  • Language: English
  • Copyright: © Elsevier 2013
  • Published: April 25, 2013
  • Imprint: Elsevier
  • eBook ISBN: 9780444627391

About the Author

Jan Harmsen

Jan Harmsen
Dr. Jan Harmsen is currently Director of Harmsen Consultancy B.V. From 1996 to 2010 he was Principal Process Developer, Shell Technology Center Amsterdam. After thirty-three years of industrial experience in exploratory research, development, process design, and chemicals manufacturing, ir. Harmsen now successfully works as an independent consultant on innovation with sustainable development in view. He has published three books with Elsevier.

Affiliations and Expertise

Harmsen Consultancy B.V., The Netherlands

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