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Indole Alkaloids - 1st Edition - ISBN: 9780323916745

Indole Alkaloids

1st Edition

Spirooxindole

Authors: Maliha Uroos Abdul Hameed Sadia Naz Muhammad Raza Shah
Paperback ISBN: 9780323916745
Imprint: Elsevier
Published Date: 1st January 2022
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Description

Indole Alkaloids: Spirooxindole presents the multistep synthesis of natural products using schematic diagrams. This approach provides a quick and easy way to review and understand new and novel synthetic strategies to construct structural frameworks of natural products. Natural product synthesis is a fascinating research area due to the unique structural architecture and bioactivities of natural products. A volume in the Visual Guides to Natural Product Synthesis series, this book presents the schematic total syntheses of natural products containing “spirooxindole” core structure.Spirooxindole natural products are interesting to synthetic chemists due to their vast structural diversity and broad biological spectrum. A number of spirooxindole motifs have been prepared in lab both via stereoselective and racemic approaches following multistep synthetic protocols. This book covers the spirooxindole molecules through visual diagrams, highlighting the key steps involved in total, formal and semi-syntheses. The spirooxindole visual guide covers Brevianamide A and B, Citrinadin A and B, Coerulescine and Horsfiline, Elacomine and Isoelacomine, Gelsemine, Paraherquamide A and B, Rynchophylline, Isorynchophylline, Spirotryprostatin A and B and Strychnofoline. The visual layouts provide quick and easy access to the developed synthetic routes towards the targeted spirooxindoles. This book is an essential reference for researchers working in the area of organic synthesis and natural products, especially those who are involved in the development of new, efficient and novel methodologies for natural product synthesis.

Key Features

  • Outlines synthetic strategies for natural products bearing spirooxindole core structure
  • Includes schematic diagrams of multistep synthetic routes highlighting key steps along the way
  • Describes all routes for formal synthesis, semi-synthesis and total synthesis of spirooxindole alkaloids

Readership

Researchers working in the area of organic synthesis and natural products, especially those who are involved in the development of new, efficient and novel methodologies for natural product synthesis

Table of Contents

  1. Indole alkaloids; Spirooxindoles
    2. Brevianamide A and B
    3. Citrinadin A and B
    4. Coerulescine and Horsfiline
    5. (±)-Elacomine and (±)-Isoelacomine
    6. Gelsemine
    7. Paraherquamide A and B
    8. Rynchophylline and Isorynchophylline
    9. Spirotryprostatin A
    10. (‒)-Spirotryprostatin B
    11. Strychnofoline

Details

Language:
English
Copyright:
© Elsevier 2022
Published:
1st January 2022
Imprint:
Elsevier
Paperback ISBN:
9780323916745

About the Authors

Maliha Uroos

Dr. Maliha Uroos completed her PhD in synthetic organic chemistry in 2012 from the University of Nottingham under HEC Faculty Development Scholarship. She was awarded EPSRC post-doctoral fellowship (2012-13) at the University of Nottingham, UK. She was appointed Lecturer at University of the Punjab in 2007 and currently working as Associate Professor (2020 to date) and Director, Centre for Research Ionic Liquid, School of Chemistry, University of the Punjab. Her main focus is synthetic organic chemistry and research interests include synthesis and applications of ionic liquids, synthesis of biologically active molecules, sustainable energy production and development of green processes for setting up bio-refinery from agricultural waste.

Abdul Hameed

Dr. Abdul Hameed Dr. Abdul Hameed completed his PhD in Organic Chemistry from The University of Nottingham, UK. He worked in the area of natural products synthesis. He was a post-doc fellow in Max-Planck Institut für Polymerforschung, Germany in synthetic division headed by Prof. Dr. Klaus Müllen. There he worked on the functionalization of adenylyl cyclsase inhibitors via chemical methods to conjugate them with monoclonal antibody to study their biological potential in Regulatory T cells (Treg). His current research interests are including the development of novel methodologies, their utilization in natural products synthesis, the synthesis heterocyclic compound compounds to evaluate their biological potential.

Affiliations and Expertise

Department of Chemistry, University of Sahiwal, Sahiwal 57000, Pakistan

Sadia Naz

Sadia Naz is currently a PhD student at Centre for Research Ionic Liquid, School of Chemistry, University of the Punjab (2018 to onwards) and is working as research assistant in HEC NRPU project with Dr. Maliha Uroos (2019 to onwards). She has publications in international journals and presented her work in various international and national conferences. Her research interests include synthetic organic chemistry, ionic liquids, conversion of agricultural waste materials into valuable platform chemicals.

Muhammad Raza Shah

Prof. Dr. Muhammad Raza Shah is a Full Professor at the International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University of Karachi, Pakistan. He is also the Head of the Center for Bioequivalence Studies and Clinical Research (CBSCR) and the recipient of numerous awards, including the civil award Tamgha-i-Imtiaz from President of Pakistan, and the Dr. M. Raziuddin Siddiqi Prize (2015) for Scientists under 40 in the Field of Chemistry by Pakistan Academy of Sciences. He has written over 200 peer-reviewed journal papers.

Affiliations and Expertise

Professor, International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University, Karachi, Pakistan

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