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Awareness among clinicians about PIDs, which consist of more than 400 different entities, plays an important role in ensuring that patients receive a timely diagnosis. Furthermore, clinicians who are educated about PIDs can give their patients access to optimal management of their condition, thus helping the patient achieve a better quality-of-life and long-term prognosis.
Inborn Errors of Immunity: A Practical Guide provides the most up-to-date information for busy students, nurses, clinical residents, practicing physicians, and even basic researchers. Readers will benefit from a well-structured breakdown of complicated PID diseases, including approaches to their clinical signs/symptoms and immunologic/laboratory findings.
- Presents valuable contribution of more than 40 expert chapter authors, from top centers spanning five continents, each in a specific PID field
- Covers various aspects of PID using updated clinical guidelines and standard stepwise pipelines
- Focuses on the latest developments in the molecular diagnosis and pathogenesis of diseases, with easy explanation and schematic representation of defective signaling pathways
- Includes dedicated sections for clinical features and immunological tests with carefully-curated figures of PID manifestations, imaging, and histological/pathological illustrations to create the first PID medial-color atlas
- Summarizes the updated conventional and specific treatments and follow-up notes for different PID diseases
General practitioners, hospital clinicians; specialists including pediatricians, infectious disease specialists, allergy and immunology specialists, and rheumatologists
2. Immunodeficiencies affecting cellular and humoral immunity
3. Combined immunodeficiencies with associated or syndromic features
4. Predominantly Antibody Deficiencies (PADs)
5. Diseases of immune dysregulation
6. Phagocyte defects
7. Defects in Intrinsic and Innate immunity
8. Auto-inflammatory disorders
9. Complement deficiencies
10. Phenocopies of PID
11. Treatment and Management
- No. of pages:
- © Academic Press 2021
- 22nd January 2021
- Academic Press
- Paperback ISBN:
- eBook ISBN:
Asghar Aghamohammadi was a Professor in Pediatrics and Clinical Immunology, at the Tehran University of Medical Sciences (TUMS) in Iran. He directed the Research Center for Immunodeficiencies (RCID), the pre-eminent centre in Iran for primary immunodeficiency. He completed a fellowship in Great Ormond Street Hospital, UK and earned a PhD from the University of Toyama, Japan. His work focused on primary immunodeficiency, including primary antibody deficiency disorders, molecular diagnosis, and patient treatment and management. His work has been widely published and referred to in his field.
Professor, Department of Pediatrics; President, RCID, Pediatrics Center of Excellence, Children's Medical Center, TUMS, Iran
Hassan Abolhassani is a leading member of the Junior Faculty at the Karolinska Institute (KI) and a team leader at Division of Clinical Immunology in the Department of Laboratory Medicine, KI in Sweden. He received his MD and his first PhD in Immunogenetics from TUMS and his second PhD in Clinical Immunology from the KI. His work focuses on the gene discovery and pathogenesis of primary antibody deficiency and the immune pathways involved, to help physicians and immunologists understand immune-related genes with unknown functions. He has received numerous academic awards and is widely published in the field.
Team leader, Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden
Nima Rezaei is a Professor of clinical immunology at TUMS, vice dean of international affairs in the School of Medicine, and deputy president of RCID. He received his PhD in clinical immunology and human genetics from the University of Sheffield in the UK after graduation in medicine (MD) from TUMS. He wrote hundreds of papers and edits for leading book series and is the founding president of Universal Scientific Education and Research Network (USERN). He has published more than 670 articles in the field of basic and clinical immunology and primary immunodeficiency.
Professor of Clinical Immunology, Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Reza Yazdani is Assistant Professor at the RCID, TUMS, in Iran. He is an academic member of the RCID, the pre-eminent centre in Iran for primary immunodeficiency. He holds a PhD in medical immunology focusing on basic immunologic methodologies and immunologic phenotyping of patients with primary antibody deficiency. He has received numerous awards and honors and published over 100 papers in the field.
Assistant Professor, RCID, Pediatrics Center of Excellence, Children's Medical Center, TUMS, Iran
"This is definitely a very useful book for the intended audiences. It is easier to read and more engaging than other heavy, detail-oriented books in this area, such as Primary Immunodeficiency Diseases: A Molecular and Genetic Approach, 3rd edition, Ochs et al. (Oxford University Press, 2014), or Primary Immunodeficiency Diseases: Definition, Diagnosis, and Management, 2nd edition, by Rezaei et al. (Springer, 2017), which focus more on the molecular/genetic details and the pathophysiology of the diseases." --© Doody’s Review Service, 2021, Pavadee Poowuttikul, MD(Children's Hospital of Michigan), reviewer, expert opinion
"This book is a fittingly titled, well-written publication. As a lengthy read, Stiehm's utility proves more to be as a comprehensive and informative reference book and guide for clinicians and any other readers interested in immunodeficiency. Readers will be able to easily navigate this well-organized text that provides outstanding details pertaining to immunodeficiencies and their common presentations, diagnostic approaches, and laboratory evaluations for diseases and a focused discussion on immunodeficiency management. Each chapter guides the reader by setting the tone with an overview or introduction, priming the reader for the in-depth text. Furthermore, the reader will find in-color illustrations, pictures, and imaging, which provides a visual aid in helping to solidify the understanding for the rare and complicated conditions discussed. In addition, of great value are the authors' use of tables that serve as an excellent quick reference for a plethora of topics ranging from various syndromes and their associated gene defects to therapeutic uses of vaccines in patients with immunodeficiency." --Annals of Allergy, Asthma and Immunology
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