In Vivo Models to Study Angiogenesis

In Vivo Models to Study Angiogenesis

1st Edition - August 18, 2017

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  • Author: Domenico Ribatti
  • Paperback ISBN: 9780128140208
  • eBook ISBN: 9780128140215

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In Vivo Models to Study Angiogenesis provides the latest information and an overview of the most common assays for studying angiogenesis in vivo. Under physiological conditions, angiogenesis is tightly controlled, whereas increased production of angiogenic stimuli and/or reduced production of angiogenic inhibitors leads to abnormal neovascularization, such as occurs in cancer, chronic inflammatory disease, diabetic retinopathy, macular degeneration and cardiovascular disorders. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system. This book presents the latest information from the extensive literature and research available. Evidence is now emerging that blood vessels themselves have the ability to provide instructive regulatory signals to surrounding non-vascular target cells during organ development. Thus, endothelial cell signaling is currently believed to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation and postnatal tissue remodeling.

Key Features

  • Provides information on the most common assays to study angiogenesis in vivo
  • Presents an ideal reference for those interested in angiogenesis as a normal and vital process in growth and development
  • Covers wound healing, the formation of granulation tissue, and the transition of tumors from benign to malignant


Researchers and postgraduates working on angiogenesis, tissue engineering, oncology-- particularly early-career and PhD-level researchers

Table of Contents

  • The chorioallantoic membrane
    The corneal micropocket assay
    The zebrafish embryo
    The sponge implant method
    The Matrigen implant assay
    In vivo gene transfer with AAV vectors
    In vivo tumor models

Product details

  • No. of pages: 112
  • Language: English
  • Copyright: © Academic Press 2017
  • Published: August 18, 2017
  • Imprint: Academic Press
  • Paperback ISBN: 9780128140208
  • eBook ISBN: 9780128140215

About the Author

Domenico Ribatti

Domenico Ribatti was awarded his M.D. degree in October 1981, with full marks. In 1983, D.R. joined the Medical School as Assistant at the Institute of Human Anatomy, University of Bari. In 1984, he took the specialization in Allergology. In 1989, he spent one year in Geneva, working at the Department of Morphology (Prof. R. Montesano). In 2008, he received the honoris causa degree in Medicine and Pharmacy form the University of Timisoara (Romania). D.R. is author of 866 publications as reported in PUBmed and contributed to 50 chapters to books. Overall, his papers have been cited 51153 times. He has published many books with both Elsevier and Springe

Affiliations and Expertise

Full Professor of Human Anatomy, University of Bari Medical School, Bari, Italy

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