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In Vivo Models to Study Angiogenesis - 1st Edition - ISBN: 9780128140208, 9780128140215

In Vivo Models to Study Angiogenesis

1st Edition

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Author: Domenico Ribatti
Paperback ISBN: 9780128140208
eBook ISBN: 9780128140215
Imprint: Academic Press
Published Date: 21st August 2017
Page Count: 112
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In Vivo Models to Study Angiogenesis provides the latest information and an overview of the most common assays for studying angiogenesis in vivo. Under physiological conditions, angiogenesis is tightly controlled, whereas increased production of angiogenic stimuli and/or reduced production of angiogenic inhibitors leads to abnormal neovascularization, such as occurs in cancer, chronic inflammatory disease, diabetic retinopathy, macular degeneration and cardiovascular disorders. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system. This book presents the latest information from the extensive literature and research available.

Evidence is now emerging that blood vessels themselves have the ability to provide instructive regulatory signals to surrounding non-vascular target cells during organ development. Thus, endothelial cell signaling is currently believed to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation and postnatal tissue remodeling.

Key Features

  • Provides information on the most common assays to study angiogenesis in vivo
  • Presents an ideal reference for those interested in angiogenesis as a normal and vital process in growth and development
  • Covers wound healing, the formation of granulation tissue, and the transition of tumors from benign to malignant


Researchers and postgraduates working on angiogenesis, tissue engineering, oncology-- particularly early-career and PhD-level researchers

Table of Contents

The chorioallantoic membrane
The corneal micropocket assay
The zebrafish embryo
The sponge implant method
The Matrigen implant assay
In vivo gene transfer with AAV vectors
In vivo tumor models


No. of pages:
© Academic Press 2018
21st August 2017
Academic Press
Paperback ISBN:
eBook ISBN:

About the Author

Domenico Ribatti

Domenico Ribatti was awarded his M.D. degree on October 1981, with full marks. In 1983, Dr. Ribatti joined the Medical School as Assistant at the Institute of Human Anatomy, University of Bari. In 1984, he took the specialization in Allergology. In 1989, he spent one year in Geneva, working at the Department of Morphology (Prof. R. Montesano). In 2008, he received the honoris causa degree in Medicine and Pharmacy from the University of Timisoara (Romania). His present position is full professor of Human Anatomy at the University of Bari Medical School. Domenico Ribatti is author of 718 publications as reported in PubMed and contributed to 50 chapters to books. With Dr. Francesco Pezzella, Dr. Ribatti co-edited the book Tumor Vascularization, published on January 2020 by Elsevier/Academic Press.

Affiliations and Expertise

Professor of Human Anatomy, Department of Basic Biomedical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, Italy

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