In Situ Tissue Regeneration

In Situ Tissue Regeneration

Host Cell Recruitment and Biomaterial Design

1st Edition - July 17, 2016

Write a review

  • Editors: Sang Jin Lee, Anthony Atala, James Yoo
  • Paperback ISBN: 9780128022252
  • eBook ISBN: 9780128025000

Purchase options

Purchase options
Available
DRM-free (PDF, Mobi, EPub)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order

Description

In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body’s ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body’s own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications.

Key Features

  • Explores the body’s ability to mobilize endogenous stem cells to the site of injury
  • Details the latest strategies developed for inducing and supporting the body’s own regenerating capacity
  • Presents smart biomaterials in cell-based tissue engineering applicationsfrom the cell level to applications—in the first unified volume
  • Features chapter authors and editors who are authorities in this emerging field
  • Prioritizes a discussion of the future direction of smart biomaterials for in situ tissue regeneration, which will affect an emerging and lucrative industry

Readership

Biomedical researchers engaged in cell biology, stem cell research, regenerative medicine, and engineering biomaterials.

Table of Contents

  • 1. Fundamentals of In Situ Tissue Regeneration
    Sang Jin Lee, James J. Yoo and Antony Atala
    2. Stem Cell Homing
    Mariusz Z. Ratajczak and Ahmed A. Ismail
    3. Immunology – Host Responses to Biomaterials
    John D. Jackson

    4. Foreign Body Reaction and Stem Cell Responses
    Ashwin Nair and Liping Tang

    5.  Roles of endogenous growth factors and small peptides in in situ tissue regeneration
    Suna Kim, Hyun Sook Hong and Youngsook Son

    6. Small molecules: Controlling cell fate and function
    Baisong Lu and Anthony Atala

    7. Small RNA Delivery for In Situ Tissue Regeneration
    NaJung Kim, James J. Yoo, Anthony Atala, and Sang Jin Lee
    8. Micro and Nano Topographical cues guiding biomaterial host response
    Deepak M. Kalaskar and Feras Alshomer

    9. Mechanobiology and Mechanotherapy in Tissue Engineering
    Rei Ogawa

    10. A biomimetic strategy to design biomaterials for in situ tissue regeneration
    Ji Hyun Kim and Sang Jin Lee

    11. Impact of Matrix Dynamic Properties on Stem Cell Viability
    Marc B. Taraban1, Yuqi Li, Katherine A. Joyner, Joseph P. Stains and Yihua B. Yu

    12. Cell-free Scaffolds for In situ Tissue Regeneration
    Seung Hun Park, Bo Keun Lee, James Yoo, Sang Jin Lee and Moon Suk Kim

    13. In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design
    T. Konrad Rajab and Harald Ott

    14. Synovial Joint: In Situ Regeneration of Osteochondral and Fibrocartilaginous Tissues by Homing of Endogenous Cells
    Solaiman Tarafder and Chang H. Lee

    15. Bioengineered strategies for tendon regeneration
    Ana I. Gonçalves, Márcia T. Rodrigues, Rui L. Reis and Manuela E. Gomes

    16. Volumetric Muscle Repair In Situ
    Lindsey E. Shapiroa, Ji Hyun Kima, In Kap Ko, Sang Jin Lee,  James J. Yoo and Anthony Atalaa

    17. Mending The Heart Through In Situ Cardiac Regeneration
    Jeremy Choon Meng Teo, Selwa Mokhtar Boularaoui, Noaf Salah Ali AlWahab and Nicolas Christoforou

    18. Skin Wound Healing – Skin Regeneration with Pharmacological Mobilized Stem Cells
    Zhaoli Sun and George Melville Williams

    19. In situ renal regeneration
    Hung-Jen Wang, Sang Jin Lee, Anthony Atala and James J. Yoo

    20. Regulatory Aspects: regulation aspects of cell-free biomaterial implants
    Nan Zhang, Alexander Baume, Richard Payne, Julie Allickson

    21. Business Perspective – case study:  commercialized cell-free cardiovascular implant
    Alexander Sheehy, Byron Lambert and Richard Rapoza

Product details

  • No. of pages: 458
  • Language: English
  • Copyright: © Academic Press 2016
  • Published: July 17, 2016
  • Imprint: Academic Press
  • Paperback ISBN: 9780128022252
  • eBook ISBN: 9780128025000

About the Editors

Sang Jin Lee

Assistant Professor, Wake Forest Institute for Regenerative Medicine, Winston-Salem, North Carolina

Affiliations and Expertise

Assistant Professor, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC, USA

Anthony Atala

Anthony Atala, MD, is the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine, and the W. Boyce Professor and Chair of Urology. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine. Fifteen applications of technologies developed in Dr. Atala's laboratory have been used clinically. He is Editor of 25 books and 3 journals. Dr. Atala has published over 800 journal articles and has received over 250 national and international patents. Dr. Atala was elected to the Institute of Medicine of the National Academies of Sciences, to the National Academy of Inventors as a Charter Fellow, and to the American Institute for Medical and Biological Engineering. Dr. Atala has led or served several national professional and government committees, including the National Institutes of Health working group on Cells and Developmental Biology, the National Institutes of Health Bioengineering Consortium, and the National Cancer Institute’s Advisory Board. He is a founding member of the Tissue Engineering Society, Regenerative Medicine Foundation, Regenerative Medicine Manufacturing Innovation Consortium, Regenerative Medicine Development Organization, and Regenerative Medicine Manufacturing Society.

Affiliations and Expertise

Professor, Wake Forest Institute for Regenerative Medicine

James Yoo

Professor, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC

Affiliations and Expertise

Professor, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC, USA

Ratings and Reviews

Write a review

Latest reviews

(Total rating for all reviews)

  • Akio K. Mon May 14 2018

    Beginning of new era of biomaterials

    I think this book suggests clear direction for young researchers of biomaterials. Along with regenerative medicine, the concept of "in situ tissue regeneration" will be an important basic principle.