Improving the Therapeutic Ratio in Head and Neck Cancer - 1st Edition - ISBN: 9780128178683

Improving the Therapeutic Ratio in Head and Neck Cancer, Volume 6

1st Edition

Series Volume Editors: Randall Kimple
Hardcover ISBN: 9780128178683
Imprint: Academic Press
Published Date: 6th January 2020
Page Count: 300
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Table of Contents

1. Overview of head and neck cancer management
2. The role of immunotherapy and molecularly targeted therapies in head and neck cancer
3. Targeting the PI3K/mTOR pathway
4. Autophagy inhibition to sensitize HNC to radiation and chemotherapy
5. Overcoming head and neck cancer stem cells
6. TAM Family proteins and therapy resistance
7. Eph/Ephrin family proteins and theapy resistance
8. Metabolic reprogramming to modulate therapeutic sensitivity
9. FGFR and cMET
10. Targeting GPCRs in HNC
11. Improving the response to immunotherapy
12. Chk1/2 inhibition in radiation and cetuximab resistance


Description

Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic.

The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance.

This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites.

Key Features

  • Provides key scientific background for clinicians when developing novel clinical trials and important examples for basic scientists of the types of work required to move a concept from the lab to the clinic
  • Presents consistent pathway diagrams in each chapter, thus making it easier to understand complicated pathways
  • Includes chapter summaries of the critical next steps needed to move studies from their current state into practice changing clinical data

Readership

Cancer researchers; oncologists; graduate students


Details

No. of pages:
300
Language:
English
Copyright:
© Academic Press 2020
Published:
Imprint:
Academic Press
Hardcover ISBN:
9780128178683

Ratings and Reviews


About the Series Volume Editors

Randall Kimple Series Volume Editor

Dr. Kimple completed his MD, PhD in Pharmacology, and residency in Radiation Oncology at the University of North Carolina. He is an Associate Professor of Human Oncology at the University of Wisconsin School of Medicine and Public Health where he is a member of the Multidisciplinary Head and Neck Program and the Wisconsin Head and Neck Cancer SPORE Grant. He runs a translational research lab focused on understanding the molecular basis of therapeutic resistance in head and neck cancer.

Affiliations and Expertise

Associate Professor, Department of Human Oncology, UW Carbone Comprehensive Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA