Implementing Precision Medicine in Best Practices of Chronic Airway Diseases

1st Edition - September 19, 2018
Editors: Ioana Agache, Peter Hellings
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 1 3 4 7 1 - 9
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 3 4 7 2 - 6

Implementing Precision Medicine in Best Practices of Chronic Airway Diseases provides a comprehensive overview of the application of precision medicine in airway diseases with a go… Read more

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Implementing Precision Medicine in Best Practices of Chronic Airway Diseases provides a comprehensive overview of the application of precision medicine in airway diseases with a goal of promoting optimal control of disease, higher patient satisfaction and disease prevention. As medical research continues to fund this area, the book highlights the need for implementation of the principles of precision medicine into the bedside management of chronic airway diseases. It is clear that chronic airway diseases are heterogeneous and that a personalized approach is warranted whereby treatment is tailored to the level of the individual patient.Written for basic researchers, medical doctors and other healthcare practitioners this book provides guidance on the implementation of the principles of precision medicine into further research and daily clinical practice.

Part I The Concept of Precision Medicine and Precision Health

1. The Audacious Goal of Precision Medicine

2. Critical Entry Points—Genetics and Epigenetics

3. Critical Entry Points—Microbiome

4. Factors Modulating the Disease Endotype

5. Revised Disease Nomenclature Including Disease Endotypes

Part II Shortcomings of Current Care Pathways for Chronic Airways Diseases

6. The Global Burden of Chronic Airway Diseases

7. Unmet Needs in Chronic Upper Respiratory

Part III Personalized Care: Endotype-driven Treatment

8. Endotype-Driven Approach for Asthma

9. Endotype-Driven Approach for Chronic Rhinosinusitis

10. Endotype-Driven Approach in Rhinitis

11. Prevention of Allergies

12. Prevention of Asthma

13. Prevention of Chronic Rhinosinusitis

14. Current and Future Biomarkers for Allergy and Asthma

15. Validation and Qualification of Biomarkers and Their Translation Into Pathway-Specific Diagnostic Tests

16. Critical Issues for the Endotype/Biomarkers Approach

17. Key Points for Moving the Endotypes Field Forward

Part IV Health Information Technology and PM

18. Telemedicine and Mobile Health Technology in the Diagnosis, Monitoring and Treatment of Respiratory Allergies

19. Real-Time Clinical Decision Support at the Point of Care

20. Patient-Friendly HIT Tools and the Advent of Crowdsourcing Clinical Trials

Part V Participation of the Patient

21. The Patient-Centered Decision System as per the 4Ps of PRECISION MEDICINE

22. Interpersonal Dimensions of Personalized Medicine for Chronic Obstructive Pulmonary Disease

Part VI Bringing Precision Medicine to the Clinic

23. Big Data Translation Into Clinical Decision Algorithms

24. European Union Funding of Research on Airway Diseases

25. Provision of Care - Implementation of the Finnish Allergy Programme 2008-2018

26. Improving Understanding and Common Usage of Disease Phenotypes, Endotypes, Biomarkers and Precision Therapies at the Point of Care

27. Full Patient Monitoring Using Digital Health Technology

28. Global Multidisciplinary Networks

29. EUFOREA Approach to Precision Medicine in Respiratory Diseases

Ioana Agache

Ioana Agache is Professor in Allergy and Clinical Immunology at Transylvania University, Brasov, Romania and President of the European Academy of Allergy and Clinical Immunology (EAACI) 2017-2019. Her research in the field of Asthma and Allergy and Clinical Immunology focused on several key areas, ranging from asthma phenotypes and endotypes and immune modulation and immune tolerance to the concept of integrated management of allergic diseases, with a special focus on the primary care system and the community pharmacists. She is member of the Steering Committee and co-author of several international and European Guidelines, such as ARIA (Allergic Rhinits and its impact on Asthma), EAACI Allergen Immunotherapy Guidelines and EAACI Food Allergy and Anaphylaxis Guidelines. She is Editor of the Global Atlas of Asthma (2013), Global Atlas of Allergy (2014), Global Atlas of Allergic Rhinitis and Chronic Rhinosinusitis (2015), Associate Editor of Clinical and Translational Allergy and a member of the Editorial Board for Journal of Allergy and Clinical Immunology and Allerhy. Ioana Agache graduated with a medical degree from “Carol Davila” University, Bucharest and absolved Magna Cum Laude her PhD in Internal Medicine.

Affiliations and expertise

Professor, Allergy and Clinical Immunology, Transylvania University, Brasov, Romania

Peter Hellings

Since August 2004 Dr. Peter Hellings has been working at the Dept. of Otorhinolaryngoloy of the University Hospitals Leuven and was nominated docent and head docent at the KU Leuven in 2004 and 2008 respectively. He has been nominated full professor (hoogleraar) at the KU Leuven in Oct. 2012. Since 2014, he is also nominated full professor (hoogleraar) at the Academic Medical Center in Amsterdam, and nominated guest professor at the University of Ghent in 2015. He has been the organizing president of the annual meeting of the European Academy of Facial Plastic Surgery in Bruges in 2011, under the High Patronage ofH.R.H.ueen Mathilde of Belgium, and of the bi-annual European scientific SERIN meeting in Leuven in 2013, under the High Patronage of H.R.H. Princess Astrid of Belgium. He became member of the Royal Academy of Medicine of Belgium in 2012, and current secretary of the Commission International Relations. After being chair of the ENT section, he is the Secretary-General of the European Academy of Allergy

Affiliations and expertise

University Hospitals Leuven, Belgium