Implementing Precision Medicine in Best Practices of Chronic Airway Diseases - 1st Edition - ISBN: 9780128134719

Implementing Precision Medicine in Best Practices of Chronic Airway Diseases

1st Edition

Editors: Ioana Agache Peter Hellings
Paperback ISBN: 9780128134719
Imprint: Academic Press
Published Date: 27th August 2018
Page Count: 226
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Implementing Precision Medicine in Best Practices of Chronic Airway Diseases provides a comprehensive overview of the application of precision medicine in airway diseases with a goal of promoting optimal control of disease, higher patient satisfaction and disease prevention. As medical research continues to fund this area, the book highlights the need for implementation of the principles of precision medicine into the bedside management of chronic airway diseases. It is clear that chronic airway diseases are heterogeneous and that a personalized approach is warranted whereby treatment is tailored to the level of the individual patient.

Written for basic researchers, medical doctors and other healthcare practitioners this book provides guidance on the implementation of the principles of precision medicine into further research and daily clinical practice.

Key Features

  • Bridges the gap between precision medicine research and the implementation of the principles into daily clinical practice
  • Includes contributions from key opinion leaders in the field of airway disease giving a worldwide perspective
  • Discusses precision medicine in terms of personalized and stratified medicine, biomarkers, prediction of success, participation of the patient and prevention of disease


Researchers and medical doctors and scientists in the field of airway diseases, including pulmonologist, ear nose throat specialists, pediatricians, allergologists, general practitioners

Table of Contents

I. The concept of Precision Medicine and Precision Health
1. The audacious goal of precision medicine
2. The tools of Precision Medicine
3. The stakeholders network

II. Shortcomings of current care pathways for chronic airways diseases
4. The global burden of chronic airways diseases
5. Unmet needs in chronic respiratory diseases

III. Personalized care: endotype-driven treatment
6. New approaches defining allergic disease endotypes
7. Factors modulating the disease endotype
8. Linking disease phenotypes and endotypes
9. Validation and qualification of biomarkers and their translation into pathway-specific diagnostic tests
10. Endotype-driven approach for rhinitis
11. Endotype-driven approach for rhinosinusitis
12. Endotype-driven approach for asthma
13. Endotype-driven approach for COPD
14. Big data translation into clinical decision algorithms
15. Predictive aspects – measures of success
16. Critical issues for the endotype/biomarkers driven approach
17. Key points for moving the endotypes field forward

IV. Health information technology and PM
18. Innovative health IT
19. Correlation and trend analysis tools
20. Real-time clinical decision support at the point of care
21. Patient-friendly HIT tools and the advent of crowdsourcing clinical trials
22. Global HIT systems – opportunities and challenges

V. The vision of precision health
23. Identification of ‘classical’ and ‘novel’ phenotypes in existing birth cohorts, their validation and redefinition
24. Discovery of the relevant mechanisms
25. The merger between traditional medicine and population health
26. Critical entry points – genetics and epigenetics
27. Critical entry points - microbiome

VI. Participation of the patient
28. The patient-centered environment
29. Interpersonal dimensions (relationship)
30. Clinical dimensions (provision of care)
31. Structural dimensions (system’s features)
32. The KPIs of patient centered environment

VII. Bringing Precision Medicine to the clinic
33. Improved understanding and common usage of disease phenotypes, endotypes, biomarkers and precision therapies at the point of care
34. Revised disease nomenclature including disease endotypes
35. Full patient monitoring using novel digital technology and the concept of endotypes/novel biomarkers/patient centered care
36. Global, multi-discipline partnerships
37. Rethinking healthcare
38. The right balance between research and political priorities
39. Stakeholders network coordination


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© Academic Press 2018
Academic Press
Paperback ISBN:

About the Editor

Ioana Agache

Ioana Agache is Professor in Allergy and Clinical Immunology at Transylvania University, Brasov, Romania and President of the European Academy of Allergy and Clinical Immunology (EAACI) 2017-2019. Her research in the field of Asthma and Allergy and Clinical Immunology focused on several key areas, ranging from asthma phenotypes and endotypes and immune modulation and immune tolerance to the concept of integrated management of allergic diseases, with a special focus on the primary care system and the community pharmacists. She is member of the Steering Committee and co-author of several international and European Guidelines, such as ARIA (Allergic Rhinits and its impact on Asthma), EAACI Allergen Immunotherapy Guidelines and EAACI Food Allergy and Anaphylaxis Guidelines. She is Editor of the Global Atlas of Asthma (2013), Global Atlas of Allergy (2014), Global Atlas of Allergic Rhinitis and Chronic Rhinosinusitis (2015), Associate Editor of Clinical and Translational Allergy and a member of the Editorial Board for Journal of Allergy and Clinical Immunology and Allerhy. Ioana Agache graduated with a medical degree from “Carol Davila” University, Bucharest and absolved Magna Cum Laude her PhD in Internal Medicine.

Affiliations and Expertise

Professor, Allergy and Clinical Immunology, Transylvania University, Brasov, Romania

Peter Hellings

Since August 2004 Dr. Peter Hellings has been working at the Dept. of Otorhinolaryngoloy of the University Hospitals Leuven and was nominated docent and head docent at the KU Leuven in 2004 and 2008 respectively. He has been nominated full professor (hoogleraar) at the KU Leuven in Oct. 2012. Since 2014, he is also nominated full professor (hoogleraar) at the Academic Medical Center in Amsterdam, and nominated guest professor at the University of Ghent in 2015. He has been the organizing president of the annual meeting of the European Academy of Facial Plastic Surgery in Bruges in 2011, under the High Patronage ofH.R.H.ueen Mathilde of Belgium, and of the bi-annual European scientific SERIN meeting in Leuven in 2013, under the High Patronage of H.R.H. Princess Astrid of Belgium. He became member of the Royal Academy of Medicine of Belgium in 2012, and current secretary of the Commission International Relations. After being chair of the ENT section, he is the Secretary-General of the European Academy of Allergy

Affiliations and Expertise

University Hospitals Leuven, Belgium

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