Description

Diseases of the digestive system have a higher morbidity rate than any other group of disorder. There is a growing body of evidence that the immune system participates in the pathogenesis of a wide range of these diseases, including peptic ulcer disease and the gastropathy induced by nonsteroidal anti-inflammatory drugs (NSAIDS). For these reasons, efforts to develop novel therapies for digestive diseases are increasingly focused on the immune system. This volume reviews the immunopharmacology of the gastrointestinal tract at four distinct levels: Immunomodulation at a cellular level Cellular targers for immunomodulating drugs Specific classes of inflammatory mediators Utility and mechanisms of action of glucocorticoids in the treatment of diseases of the gastrointestinal tract.

Table of Contents

Contributors. Series Preface. Preface. Neuromodulation of Gastrointestinal Immune and Inflammatory Responses, A.D. Befus. Immunomodulation of the Gastrointestinal Epithelium, M.H. Perdue and D.M. McKay. The Immune Modulation of Intestinal Motor Function, S.M. Collins. Modulation of Neutrophil Function as a Mode of Therapy for GI Inflammation, I.S. Sandhu and M.B. Grisham. The Vascular Endothelium in GI Inflammation, P.R. Kvietys and D.N. Granger. Modulation of Mast Cell Function in the GI Tract, E.Y. Bissonnette and A.D. Befus. Immuno-Pathophysiology of the Gastrointestinal Tract: Role of Platelet-Activating Factor, P. Kubes. Cytokines, F. Cominelli Immunopharmacology of Elcosanoids in the Gastrointestinal Tract, J.L. Wallace. Nitric Oxide and the Gastrointestinal Tract, B.J.R.Whittle. Glucocorticoids and Gastrointestinal Inflammation, L. Parente and K.G. Mugridge. Glossary. Key to Illustrations. Index.

Details

No. of pages:
198
Language:
English
Copyright:
© 1993
Published:
Imprint:
Academic Press
Print ISBN:
9780127328607
Electronic ISBN:
9781483289335