Immunopharmacology of Free Radical Species

M. Grootveld and C.J. Rhodes, Methods for the Detection and Measurement of Reactive Radical Species in vivo and in Vitro. V.M. Darley-Usmar, R.P. Mason, W. Chamulitrat, N. Hogg, and B. Kalyanaraman, Lipid Peroxidation and Cardiovascular Disease. C. Rice-Evans, Free Radicals and Antioxidants in Atherosclerosis. M.J. Shattock and P.S. Haddock, Oxidant Stress and the Heart: Modulation of Ion Transport Mechanisms during Ischaemia and Reperfusion. J.A. Clemens and J.A. Panetta, Free Radicals in Central Nervous System Diseases. C.J. Green, Renal Transplantation and Ischaemia-Reperfusion Injury. M.L. Kus, K. Fairburn, D.R. Blake, and P.G. Winyard, A Vascular Basis for Free Radical Involvement in Inflammatory Joint Disease. C.J. Morris, C.W. Trenam, and J.R. Earl, Reactive Oxygen Species in Skin Inflammation. M. Goss-Sampson, A.J. Vivian, and F.J. Kelly, Free Radicals, Inflammation, and Eye Diseases. N.J. Simmonds, Free Radicals in Gastrointestinal and Hepatic Disease. M.J. Jackson, A. McArdle, and S. OFarrell, Free Radicals, Muscle Fatigue, and Damage. A.J. Sinclair and J. Lunec, Free Radicals, Oxidative Stress, and Diabetes Mellitus. O.I. Aruoma and B. Halliwell, DNA Damage by Free Radicals: Carcinogenic Implications. M. Yeadon, Free Radicals in Lung Inflammation and Environmental Exposure to Pollutants. K.H. Cheeseman, Free Radicals and Liver Injury. P.H. Evans, The Conioses: Organotypic Inflammatory Oxidative Responses to Environmental Particulate Pollutants. J.A. Panetta and J.M. McCall, Reactive Oxygen: Recent Therapeutic Intervention Strategies. Glossary. Subject Index.

Free radicals have been implicated in a entire host of different human disease states, which suggests that although they may not have a pivotal causal role, they are involved in the perpetuation of disease. In recentyears, it has become evident that although free radicals most certainly do have this role in perpetuating inflammatory reactions, they have perhaps a far more important role in acting as second messenger systems to maintain normal cell function. It is theperturbations of these reactions which pose the most intriguing therapeutic challenges. This volume deals with various basic mechanisms of free radical processes and injury. The emphasis in each case is on potential therapeutic strategies developing fromthis new knowledge.

Research level pharmacologists and degree level teachers in this area.