Immunomodulation in Domestic Food Animals - 1st Edition - ISBN: 9780120392353, 9780323154888

Immunomodulation in Domestic Food Animals

1st Edition

Advances in Veterinary Science and Comparative Medicine

Editors: Bernald Charley
eBook ISBN: 9780323154888
Imprint: Academic Press
Published Date: 28th November 1990
Page Count: 348
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Immunomodulation in Domestic Food Animals covers the developments in the immunology and regulation of the immune response in domestic food animals. This book is organized into four parts encompassing 12 chapters that describe numerous factors affecting an immune response of animals and the management of these factors for food animal production. Part I provides an overview of the basic concepts of immunomodulation and the rationale for manipulating the immune response in food animals. Part II contains information on immunopotentiation using chemicals and a thorough discussion of adjuvant use. The molecular biology and in vivo use of cytokines in food animals is presented in Part III. Lastly, Part IV discusses physiologically regulated immunomodulation, including nutritional modulation of the immune response and neuroendocrine-immune interactions. This book is of great value to immunologists, microbiologists, and feed scientists and researchers.

Table of Contents




Part I: Introduction

Rationale for Using Immunopotentiators in Domestic Food Animals

I. Introduction

II. Why Are Immunomodulators Needed?

ΙII. Specific versus Nonspecific Immunomodulation

IV. Summary


Model Systems to Study Immunomodulation in Domestic Food Animals

I. Introduction

II. Stress Models

III. Glucocorticoid Immunosuppression Models

IV. Infectious Disease Model Systems

V. Summary


Mechanisms of Action of Some Immunomodulators Used in Veterinary Medicine

I. Introduction

II. Structure and Function of the Immune System

III. Immunomodulation

IV. Physiologically Important Immunomodulators

V. Synthetic Compounds with Immunomodulatory Activity

VI. Microbial Products as Immunomodulators

VII. Liposomes

VIII. Concluding Comments


Part II: Chemical Immunomodulation

Chemically Induced Immunomodulation in Domestic Food Animals

I. Introduction

II. Chemin Immunomodulation in Domestic Food Animal Species

ΙII. Chemical Immunomodulators Which Have Apparently Not Been Evaluated in Domestic Food Animals

IV. Summary


Classical and New Approaches to Adjuvant Use in Domestic Food Animals

I. Introduction

II. Aluminum Salts

ΙII. Oil Emulsions

IV. Surface Active Agents


VI. Muramyldipeptides

VII. Polymeric Adjuvants

VIII. General Conclusions


A Thymosin-Tuftsin Conjugate as a New Potential Immunomodulator in Cattle

I. Introduction

II. Tuftsin: A Macrophage Activator

ΙII. Thymosin-α: A Τ Cell Activator

IV. Thymosin-Tuftsin Conjugate (IMP-1)

V. Conclusion


Part III: Cytokine Immunomodulation

The Molecular Biology of Large Animal Cytokines

I. Cytokine Biology

II. Recombinant Bovine and Porcine Cytokines

ΙII. Conclusions


Interferon Immunomodulation in Domestic Food Animals

I. Introduction

II. Modulation of Nonspecific Antimicrobial Defense Mechanisms

ΙII. Modulation of the Specific Cellular Immune Response

IV. Enhancement of Antimicrobial Mechanisms in the Gut

V. Immunoenhancement in Noninfectious Diseases

VI. Concluding Remarks


In Vivo Use of Interleukins in Domestic Food Animals

I. Introduction

II. Rationale for Using Interleukins in Domestic Food Animals

ΙII. In Vivo Studies with Interleukins in Domestic Food Animals

IV. Conclusions and Prospects


Part IV: Physiologically Regulated Immunomodulation

Nutritional Modulation of Immunity in Domestic Food Animals

I. Introduction

II. Protein and Energy

ΙII. Fat-Soluble Vitamins

IV. Water-Soluble Vitamins

V. Minerals

VI. Conclusion


Neuroendocrine-Immune Interactions

I. Introduction

II. Characteristics of the Neuroendocrine-Immune System

ΙII. Conclusions


Potential for Improving Animal Health by Modulation of Behavior and Immune Function

I. Introduction

II. Behavior of Farm Animals

ΙII. Social Behavior and Immune Function

IV. Nonsocial Behaviors and Immune Function

V. Brain-Immune Interactions

VI. Concluding Remarks




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© Academic Press 1990
Academic Press
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About the Editor

Bernald Charley

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