Immunology of Recurrent Pregnancy Loss and Implantation Failure
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Immunology of Recurrent Pregnancy Loss and Implantation Failure

1st Edition - July 3, 2022

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  • Editor: Joanna Kwak-Kim
  • eBook ISBN: 9780323908061
  • Paperback ISBN: 9780323908054

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Description

Immunology of Recurrent Pregnancy Loss provides doctors and immunologists with the information they need to help couples who experience recurrent pregnancy losses. Sections cover unexplained infertility, repeated in vitro fertilization, embryo transfer failures, history of second or third trimester pregnancy losses of unknown cause, or pregnancy with a history of or active autoimmune and/or alloimmune disease.  Reproductive failure (RF), including recurrent pregnancy losses (RPL) and repeated implantation failures (RIF) is rather a syndrome than a disease caused by multiple etiologies, such as anatomical, endocrine, genetic, infectious, immunological, thrombotic and unexplained etiologies, hence this book strives to present the latest information. In 27 chapters, divided in 5 sections, the book introduces the current update of reproductive immunology topics in RF and provides systematic diagnostic guidelines, systemic and immune etiologies and therapeutic approaches.

Key Features

  • Provides detailed immunological background for understanding the etiology and management of reproduction failure
  • Evaluates various immunological factors involved in the pathogenesis and management of reproduction failure
  • Gives insights into various immunological and therapeutic approaches for reproduction failure

Readership

Physicians working in the field of reproduction, immunologists, and basic and laboratory scientists interested on translational science. MDs (obstetricians and gynecologists) well as PhDs (who are interested in the area of Reproductive Immunology). Graduate and medical school students, nurses and other health professionals

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • List of contributors
  • About the editor
  • Section I: Introduction
  • Chapter 1. Clinical reproductive immunology: a window to understanding reproduction and immunology
  • Abstract
  • References
  • Section II: Recurrent pregnancy losses
  • Chapter 2. Natural killer (NK) cell pathology and reproductive failure: NK cell level, NK cell cytotoxicity, and KIR/HLA-C
  • Abstract
  • 1 Introduction
  • 2 Natural killer cells—definition
  • 3 Natural killer cell-related pathologies
  • 4 Natural killer cells in reproduction
  • 5 Evaluation
  • 6 Reproductive outcome
  • 7 Treatment
  • 8 Summary and recommendations
  • References
  • Chapter 3. T helper cell pathology and recurrent pregnancy losses; Th1/Th2, Treg/Th17, and other T cell responses
  • Abstract
  • 1 The immunologic perspective of recurrent pregnancy loss
  • 2 Definition and prevalence of recurrent pregnancy loss
  • 3 Prevalence
  • 4 Immune regulations in normal pregnancy and recurrent pregnancy loss
  • 5 Diagnostic approaches
  • 6 Treatment and reproductive outcome
  • 7 Summary and recommendations
  • References
  • Chapter 4. B cell pathology and recurrent pregnancy loss
  • Abstract
  • 1 Introduction
  • 2 B cell function during pregnancy
  • 3 Immunopathologies related to reproduction
  • 4 Recurrent pregnancy loss
  • 5 Diagnosis
  • 6 Treatments
  • 7 Summary and recommendations
  • References
  • Chapter 5. Mast cell pathology and reproductive failures
  • Abstract
  • 1 Introduction
  • 2 Mast cells biology
  • 3 Role of mast cells in reproductive system
  • 4 Mast cell-related immunopathology in reproduction
  • 5 Summary and Recommendation
  • References
  • Chapter 6. Role of human leukocyte antigen in the pathogenesis of recurrent pregnancy loss
  • Abstract
  • 1 Introduction
  • 2 Recurrent pregnancy loss and human leukocyte antigen studies
  • 3 Human leukocyte antigen class I and II molecules
  • 4 Evaluation of human leukocyte antigen antigens in assisted reproduction
  • 5 Treatment
  • 6 Conclusions
  • 7 Summary and recommendations
  • References
  • Chapter 7. Stress-induced immune deviations and reproductive failure
  • Abstract
  • 1 Immune-endocrine adaptations during normally progressing pregnancies
  • 2 Maternal stress perception
  • 3 The prevalence of stress
  • 4 Neuro-endocrine-immune imbalances and pregnancy
  • 5 How to assess stress perception?
  • 6 How to treat high-stress perception?
  • 7 Consequences of maternal stress on reproductive outcome
  • 8 Summary and recommendations
  • References
  • Chapter 8. Antiphospholipid syndrome and recurrent pregnancy losses
  • Abstract
  • 1 Introduction
  • 2 Evaluations
  • 3 Clinical practice management
  • 4 Monitoring
  • 5 Delivery and puerperium
  • 6 Fetal and neonatal outcome
  • 7 aPL and infertility
  • 8 Summary and recommendations
  • References
  • Chapter 9. Antisperm antibodies and reproductive failure
  • Abstract
  • 1 Introduction
  • 2 Definition
  • 3 Prevalence
  • 4 Underlying immunopathologies related to reproduction
  • 5 Evaluation
  • 6 Treatment
  • 7 Reproductive outcomes
  • 8 Summary and recommendations
  • References
  • Chapter 10. Antithyroid antibodies and reproductive function
  • Abstract
  • 1 Introduction
  • 2 Definition of autoimmune thyroiditis
  • 3 Prevalence
  • 4 Underlying immunopathology
  • 5 Evaluation
  • 6 Treatment
  • 7 Reproductive outcomes
  • 8 Summary and recommendation
  • References
  • Chapter 11. Fetal/neonatal alloimmune-mediated thrombocytopenia and recurrent pregnancy loss
  • Abstract
  • 1 Introduction
  • 2 Definition
  • 3 Prevalence
  • 4 Underlying immunopathology related to reproduction
  • 5 Evaluation
  • 6 Treatment
  • 7 Reproductive outcomes
  • 8 Summary and recommendations
  • References
  • Chapter 12. Infectious and noninfectious endometritis and recurrent pregnancy loss
  • Abstract
  • 1 Introduction
  • 2 Definition
  • 3 Summary and recommendations
  • References
  • Chapter 13. Thrombophilic pathologies in recurrent pregnancy losses
  • Abstract
  • 1 Introduction
  • 2 Thrombophilia
  • 3 Physiologic hypercoagulability in pregnancy
  • 4 Inherited thrombophilia and recurrent pregnancy loss
  • 5 Evaluation
  • 6 Treatment of inherited thrombophilia
  • 7 Reproductive outcomes
  • 8 Summary and recommendations
  • References
  • Chapter 14. Rheumatic diseases and reproductive outcomes
  • Abstract
  • 1 Rheumatic conditions and pregnancy outcome
  • 2 Rheumatoid arthritis
  • 3 Systemic lupus erythematosus
  • 4 Systemic sclerosis
  • 5 Antiphospholipid antibody syndrome
  • 6 Neonatal lupus
  • 7 Conclusion
  • 8 Summary and recommendations
  • References
  • Section III: Repeated implantation failures
  • Chapter 15. The role of reproductive immunology in recurrent pregnancy loss and repeated implantation failure
  • Abstract
  • 1 Introduction
  • 2 Definitions and terminology
  • 3 Prevalence
  • 4 Underlying immunopathology related to reproduction
  • 5 Evaluation
  • 6 Treatment
  • 7 Reproductive outcomes
  • 8 Summary and recommendations
  • References
  • Chapter 16. The embryo in reproductive failure: immunological view
  • Abstract
  • 1 Introduction
  • 2 Embryo-derived signals influencing the local immune environment
  • 3 Embryo-endometrial dialogue
  • 4 Recurrent implantation failure
  • 5 Improving implantation rate
  • 6 Immunomodulation
  • 7 Summary and recommendations
  • References
  • Chapter 17. Natural killer cell pathology and repeated implantation failures
  • Abstract
  • 1 Introduction
  • 2 Natural killer cell and pregnancy
  • 3 Underlying immunopathologies related to reproduction
  • 4 Candidates for evaluation
  • 5 Treatment
  • 6 Summary and recommendations
  • References
  • Chapter 18. Helper T cell pathology and repeated implantation failures
  • Abstract
  • 1 The role of helper T cells in reproductive medicine
  • 2 Th cell immunopathology and repeated implantation failure
  • 3 Prevalence
  • 4 The theoretical understanding for the application of immunomodulation therapy in recurrent implantation failure
  • 5 Evaluation
  • 6 Immunomodulation treatments targeting T helper cell pathology
  • 7 Reproductive outcome
  • 8 Summary and recommendations
  • References
  • Chapter 19. B-cell pathology and repeated implantation failures
  • Abstract
  • 1 Introduction
  • 2 B-cell immunopathology and reproduction
  • 3 Dysregulation of B cells in women with repeated implantation failure
  • 4 Clinical translational perspectives of B-cell immunopathology
  • 5 Summary and recommendations
  • References
  • Chapter 20. Endometrial pathology and repeated implantation failures
  • Abstract
  • 1 Introduction
  • 2 Endometrial pathologies
  • 3 Endometrial immunopathology
  • 4 Immune treatments for women with abnormal immune profile
  • 5 Key points
  • References
  • Chapter 21. Thrombophilia, antiphospholipid antibodies, and anticoagulation in recurrent implantation failure
  • Abstract
  • 1 Introduction
  • 2 Definition of thrombophilia
  • 3 Prevalence
  • 4 Underlying immunopathologies related to reproduction
  • 5 Diagnosis
  • 6 Treatment
  • 7 Summary and recommendations
  • References
  • Section IV: Dysregulated neuroimmuneendocrine network in reproductive failures
  • Chapter 22. The ovarian immune pathology and reproductive failures
  • Abstract
  • 1 Introduction
  • 2 Ovarian immunology
  • 3 Ovarian autoimmunity
  • 4 Primary ovarian insufficiency
  • 5 Diseases associated with ovarian autoimmunity
  • 6 Diagnosis of primary ovarian insufficiency
  • 7 Treatment for autoimmune primary ovarian insufficiency
  • 8 Reproductive outcomes
  • 9 Summary and recommendations
  • References
  • Chapter 23. Polycystic ovarian syndrome and reproductive failure
  • Abstract
  • 1 Introduction
  • 2 Hyperandrogenism and reproductive failure in polycystic ovarian syndrome
  • 3 Insulin resistance and reproductive failure in polycystic ovarian syndrome
  • 4 Chronic inflammation and reproductive failures in polycystic ovarian syndrome
  • 5 Conclusion
  • 6 Summary and Recommendations
  • References
  • Chapter 24. Metabolic control of immune responses in women with recurrent pregnancy loss and recurrent implantation failure
  • Abstract
  • 1 Introduction
  • 2 Definition and prevalence
  • 3 Underlying immunometabolic pathologies related to recurrent pregnancy loss and recurrent implantation failure
  • 4 Evaluation
  • 5 Treatment and reproductive outcomes
  • 6 Summary and recommendations
  • Fundings
  • References
  • Chapter 25. Endometriosis and reproductive failures
  • Abstract
  • 1 Introduction
  • 2 Mechanism of endometriosis-related reproductive failure
  • 3 Immune aspect of endometriosis-related pregnancy failure
  • 4 Treatment options
  • 5 Summary and recommendations
  • References
  • Chapter 26. Laboratory approaches for reproductive failure: immunological biomarkers for reproductive failures
  • Abstract
  • 1 Genomic evaluation
  • 2 Local decidual measurements
  • 3 Peripheral blood cell analysis
  • 4 Autoantibodies in recurrent pregnancy loss
  • 5 Endocrine workup
  • 6 Other assays
  • 7 Summary and recommendations
  • References
  • Further reading
  • Index

Product details

  • No. of pages: 456
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: July 3, 2022
  • Imprint: Academic Press
  • eBook ISBN: 9780323908061
  • Paperback ISBN: 9780323908054

About the Editor

Joanna Kwak-Kim

Joanne Kwak-Kim Reproductive Medicine, Department of Obstetrics and Gynecology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, USA Department of Microbiology and Immunology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA Corresponding author at: Reproductive Medicine, Department of Obstetrics and Gynecology, Department of Microbiology and Immunology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, 830 West End Court, Suite 400, Vernon Hills, IL, 60061, USA. Fax: + 1 847 327 6129 Dr. Kwak has the highest scholarly output on this subject. A pioneer in the field of Reproductive Immunology, Dr. Kwak-Kim has devoted more than 25 years of her career to Reproductive Immunology research and continues to do so. She is focusing her research on unravelling the role of the immune system in pregnancy and pregnancy loss and developing treatment plans that help women maintain successful pregnancies. While attempting pregnancy, Dr Kwak-Kim and her staff co-manage patients along with their reproductive endocrinologist or primary gynaecologist. Once pregnancy occurs, co-management continues with their obstetricians or high-risk obstetricians.

Affiliations and Expertise

Reproductive Medicine, Department of Obstetrics and Gynecology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, USA

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