Immunology of Recurrent Pregnancy Loss and Implantation Failure

Immunology of Recurrent Pregnancy Loss and Implantation Failure

1st Edition - July 15, 2022

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  • Editor: Joanna Kwak-Kim
  • Paperback ISBN: 9780323908054

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Description

Immunology of Recurrent Pregnancy Loss provides doctors and immunologists with the information they need to help couples who experience recurrent pregnancy losses. Sections cover unexplained infertility, repeated in vitro fertilization, embryo transfer failures, history of second or third trimester pregnancy losses of unknown cause, or pregnancy with a history of or active autoimmune and/or alloimmune disease.  Reproductive failure (RF), including recurrent pregnancy losses (RPL) and repeated implantation failures (RIF) is rather a syndrome than a disease caused by multiple etiologies, such as anatomical, endocrine, genetic, infectious, immunological, thrombotic and unexplained etiologies, hence this book strives to present the latest information. In 27 chapters, divided in 5 sections, the book introduces the current update of reproductive immunology topics in RF and provides systematic diagnostic guidelines, systemic and immune etiologies and therapeutic approaches.

Key Features

  • Provides detailed immunological background for understanding the etiology and management of reproduction failure
  • Evaluates various immunological factors involved in the pathogenesis and management of reproduction failure
  • Gives insights into various immunological and therapeutic approaches for reproduction failure

Readership

Physicians working in the field of reproduction, immunologists, and basic and laboratory scientists interested on translational science. MDs (obstetricians and gynecologists) well as PhDs (who are interested in the area of Reproductive Immunology). Graduate and medical school students, nurses and other health professionals

Table of Contents

  • Section 1. Introduction

    Section 2. RPL of immune etiologies
    1. Autoimmune etiologies focusing antiphospholipid antibody
    2. ANA related conditions
    3. Celiac disease and RPL/RIF
    4. NK cell pathology and RF; NK cell level, NK cell cytotoxicity and KIR/HLA-C
    5. Th cell pathology and RPL; TH1/Th2, Treg/Th17, and others
    6. B cell pathology and RPL; B cell
    7. Mast cell pathology and RPL
    8. Endometrial pathology and RPL
    9. Infectious diseases that can flare immune responses; Lyme’s disease, COVID-19, etc.
    10. Thrombophilic pathology and RPL
    11. Alloimmune conditions (NAIT, Rh sensitization)

    Section 3. Repeated implantation failures of immune etiologies
    12. Autoimmune etiologies focusing antiphospholipid antibody
    13. NK cell pathology and RIF
    14. Th cell pathology and RIF
    15. B cell pathology and RIF; Allergy, Asthma and infertility
    16. Endometrial pathology and RIF
    17. Thrombophilic condition and RIF

    Section 4. Systemic immune etiologies for RIF/RPL
    18. Ovarian pathology and RIF/RPL
    19. Endometriosis and RIF/RPL
    20. ART and RIF/RPL
    21. Hormonal/metabolic diseases that can cause proinflammatory condition: autoimmune thyroiditis, PCOS, DM, vitamin D deficiency, and homocysteinemia
    22. Stress induced immune flare in women with RF

    Section 5. Treatment modalities
    23. Immunotherapy
    24. Anti-coagulant
    25. Hormonal/metabolic
    26. Reproductive supplements
    27. Vitamins: Vitamin C, D, E, Folic acid, vitamin B12, selenium, zinc
    28. Ovulation boost; DHEA, CoQ10, myoinositol, acaiberry, MACA, ALA, NAC, melatonin
    29. Anti-inflammatory- LDN (low dose naltrexone), curcumin
    30. Chinese medicine: Zishen Yutai pill, Shoutai pill

Product details

  • No. of pages: 287
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: July 15, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323908054

About the Editor

Joanna Kwak-Kim

Joanne Kwak-Kim Reproductive Medicine, Department of Obstetrics and Gynecology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, USA Department of Microbiology and Immunology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA Corresponding author at: Reproductive Medicine, Department of Obstetrics and Gynecology, Department of Microbiology and Immunology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, 830 West End Court, Suite 400, Vernon Hills, IL, 60061, USA. Fax: + 1 847 327 6129 Dr. Kwak has the highest scholarly output on this subject. A pioneer in the field of Reproductive Immunology, Dr. Kwak-Kim has devoted more than 25 years of her career to Reproductive Immunology research and continues to do so. She is focusing her research on unravelling the role of the immune system in pregnancy and pregnancy loss and developing treatment plans that help women maintain successful pregnancies. While attempting pregnancy, Dr Kwak-Kim and her staff co-manage patients along with their reproductive endocrinologist or primary gynaecologist. Once pregnancy occurs, co-management continues with their obstetricians or high-risk obstetricians.

Affiliations and Expertise

Reproductive Medicine, Department of Obstetrics and Gynecology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, USA

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