Immunology, Inflammation and Diseases of the Eye

1st Edition


  • Darlene A. Dartt
  • Reza Dana
  • Patricia D’Amore
  • Jerry Niederkorn
  • Immunology, Inflammation and Diseases of the Eye

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    This selection of articles from the Encyclopedia of the Eye provides a comprehensive overview of immunological features, diseases and inflammation of the eye and its support structures and organs. Rather than taking an immunological focus that is strictly suitable for clinicians, the volume offers a considerable basic science background and addresses a broad range of topics - the immune system of the eye, its various disorders, mechanisms of inflammation of the eye and visual system, treatment, wound healing mechanisms, stem cells, and more.

    Key Features

    • The first single volume to integrate comparative studies into a comprehensive resource on the neuroscience of ocular immunology
    • Chapters are carefully selected from the Encyclopedia of the Eye by the world's leading vision researchers
    • The best researchers in the field provide their conclusions in the context of the latest experimental results


    Students, researchers and practitioners in ophthalmology and optometry, neuroscience, immunology, physiology, cell biology, pharmacology, and related disciplines

    Table of Contents

    I. Regulation of the Immune Response of the Eye and Its Dysregulation in Inflammation and Infection
    Adaptive Immune System and the Eye: Mucosal Immunity
    Adaptive immune system and the eye: T-cell mediated immunity
    Innate immune system and the eye
    Defense mechanisms of tears and ocular surface
    Role of complement in the ocular immune response
    Immunoregulatory processes that sustain immune privilege in the eye
    Immunosupressive and anti-inflammatory molecules that maintain immune previlege of the eye
    Antigen-presenting cells in the eye and ocular surface
    Regenfus and Cursiefen- Angiogenesis in the eye
    Dry eye: An immune-based inflammation
    Penetrating keratoplasty
    Corneal epithelium- response to infection
    Immunopathogenesis of HSV Keratitis
    Immunopathogenesis of Onchocerciasis (River Blindness)
    Immunopathogenesis of pseudomonas keratitis
    Immunobiology of acanthomeba karatitis
    Pathogenesis of fungal keratitis
    Molecular and cellular mechanisms in allergic conjunctivitis
    Conjunctiva Immune surveillance
    Inflammation of the Conjunctiva
    Immunopathogenesis of experimental uveitic diseases
    Pathogenesis of Uveitis in humans
    Immunobiology of uveal melanoma
    Immunobiology of age-related macular degeneration
    Pathogenesis and Immunology of Bacterial endophthalmitis

    II. Angiogenesis in the Eye and Its Dysfunction in the Retina, Cornea and Vitreous
    Orbiatl vascular anatomy
    Developmental anatomy of retinal and choroidal vasculature
    Development of the retinal vasculature
    Physiological Anatomy of the retinal vasculature
    Physiological anatomy of the choroidal vasculature
    Properties and functions of the vessels of the ciliary body
    Anatomy and regulation of the optic nerve blood flow
    Angiogenesis in response to hypoxia
    Angiogenesis and inflammation
    Angiogenesis in wound healing
    Hemangiogenesis versus lymphangiogenesis
    Innate immunity and


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    © 2011
    Academic Press
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    About the authors

    Reza Dana

    In addition to his role as Senior Scientist and Co-Director at the Schepens Eye Research Institute, Dr. Reza Dana holds the Claes H. Dohlman Chair in Ophthalmology at Harvard Medical School. He is Director of the Cornea & Refractive Surgery Service at the Massachusetts Eye & Ear, and serves as the Vice Chairman of the Harvard Department of Ophthalmology and Associate Chief of Ophthalmology for Academic Programs at Massachusetts Eye and Ear. After graduating Summa Cum Laude from St. Paul’s School in New Hampshire, he completed his bachelor’s (Phi Beta Kappa), graduate, and medical education at Johns Hopkins University. He performed his residency in Ophthalmology at the Illinois Eye and Ear Infirmary in Chicago, followed by a clinical fellowship in Cornea and External Diseases at the Wills Eye Hospital in Philadelphia. Reza then completed additional fellowship training in Immunology and Uveitis at the Massachusetts Eye and Ear Infirmary, and in Ocular and Transplantation Immunology at the Schepens Eye Research Institute. Dr. Dana also holds a Master of Science degree in Management from Harvard University. Reza has been a member of the full-time Harvard faculty since 1995. As a clinician-scientist, he has a particular interest in the molecular and cellular mechanisms of inflammation as they pertain to the ocular surface and anterior segment pathologies, including dry eye, allergy, wound healing responses, and transplant rejection.