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Immunology, Inflammation and Diseases of the Eye - 1st Edition - ISBN: 9780123819741, 9780123819758

Immunology, Inflammation and Diseases of the Eye

1st Edition

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Editors: Darlene A. Dartt Reza Dana Patricia D’Amore Jerry Niederkorn
Paperback ISBN: 9780081016596
eBook ISBN: 9780123819758
Imprint: Academic Press
Published Date: 31st March 2011
Page Count: 448
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This selection of articles from the Encyclopedia of the Eye provides a comprehensive overview of immunological features, diseases and inflammation of the eye and its support structures and organs. Rather than taking an immunological focus that is strictly suitable for clinicians, the volume offers a considerable basic science background and addresses a broad range of topics - the immune system of the eye, its various disorders, mechanisms of inflammation of the eye and visual system, treatment, wound healing mechanisms, stem cells, and more.

Key Features

  • The first single volume to integrate comparative studies into a comprehensive resource on the neuroscience of ocular immunology
  • Chapters are carefully selected from the Encyclopedia of the Eye by the world's leading vision researchers
  • The best researchers in the field provide their conclusions in the context of the latest experimental results


Students, researchers and practitioners in ophthalmology and optometry, neuroscience, immunology, physiology, cell biology, pharmacology, and related disciplines

Table of Contents

I. Regulation of the Immune Response of the Eye and Its Dysregulation in Inflammation and Infection
Adaptive Immune System and the Eye: Mucosal Immunity
Adaptive immune system and the eye: T-cell mediated immunity
Innate immune system and the eye
Defense mechanisms of tears and ocular surface
Role of complement in the ocular immune response
Immunoregulatory processes that sustain immune privilege in the eye
Immunosupressive and anti-inflammatory molecules that maintain immune previlege of the eye
Antigen-presenting cells in the eye and ocular surface
Regenfus and Cursiefen- Angiogenesis in the eye
Dry eye: An immune-based inflammation
Penetrating keratoplasty
Corneal epithelium- response to infection
Immunopathogenesis of HSV Keratitis
Immunopathogenesis of Onchocerciasis (River Blindness)
Immunopathogenesis of pseudomonas keratitis
Immunobiology of acanthomeba karatitis
Pathogenesis of fungal keratitis
Molecular and cellular mechanisms in allergic conjunctivitis
Conjunctiva Immune surveillance
Inflammation of the Conjunctiva
Immunopathogenesis of experimental uveitic diseases
Pathogenesis of Uveitis in humans
Immunobiology of uveal melanoma
Immunobiology of age-related macular degeneration
Pathogenesis and Immunology of Bacterial endophthalmitis

II. Angiogenesis in the Eye and Its Dysfunction in the Retina, Cornea and Vitreous
Orbiatl vascular anatomy
Developmental anatomy of retinal and choroidal vasculature
Development of the retinal vasculature
Physiological Anatomy of the retinal vasculature
Physiological anatomy of the choroidal vasculature
Properties and functions of the vessels of the ciliary body
Anatomy and regulation of the optic nerve blood flow
Angiogenesis in response to hypoxia
Angiogenesis and inflammation
Angiogenesis in wound healing
Hemangiogenesis versus lymphangiogenesis
Innate immunity and angiogenesis
Mechanisms of Angiostasis
Stability and functional integrity of new blood vessels
Vessel regression
Blood-retinal barrier
Breakdown of the blood-retinal barrier
Retinal pigment epithelium barrier
Breakdown of the retinal pigement epithelium blood-retinal barrier
Retinal pigment epithelial-choroid interactions
Macular edema
Central vein occlusion
Pathological retinal angiogenesis
Proliferative vitreoretinopathy
Choroidal neovascularization
The vascular stem cell
Concept of Angiogenic Privilege
Corneal angiogenesis
Avascularity of the cornea
Anti-angiogenic properties of vitreous


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© Academic Press 2011
31st March 2011
Academic Press
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About the Editors

Darlene A. Dartt

Affiliations and Expertise

Senior Scientist, Schepens Eye Research Institute, Harvard Medical School

Reza Dana

Reza Dana

In addition to his role as Senior Scientist and Co-Director at the Schepens Eye Research Institute, Dr. Reza Dana holds the Claes H. Dohlman Chair in Ophthalmology at Harvard Medical School. He is Director of the Cornea & Refractive Surgery Service at the Massachusetts Eye & Ear, and serves as the Vice Chairman of the Harvard Department of Ophthalmology and Associate Chief of Ophthalmology for Academic Programs at Massachusetts Eye and Ear. After graduating Summa Cum Laude from St. Paul’s School in New Hampshire, he completed his bachelor’s (Phi Beta Kappa), graduate, and medical education at Johns Hopkins University. He performed his residency in Ophthalmology at the Illinois Eye and Ear Infirmary in Chicago, followed by a clinical fellowship in Cornea and External Diseases at the Wills Eye Hospital in Philadelphia. Reza then completed additional fellowship training in Immunology and Uveitis at the Massachusetts Eye and Ear Infirmary, and in Ocular and Transplantation Immunology at the Schepens Eye Research Institute. Dr. Dana also holds a Master of Science degree in Management from Harvard University. Reza has been a member of the full-time Harvard faculty since 1995. As a clinician-scientist, he has a particular interest in the molecular and cellular mechanisms of inflammation as they pertain to the ocular surface and anterior segment pathologies, including dry eye, allergy, wound healing responses, and transplant rejection.

Affiliations and Expertise

Schepens Eye Research Institute, Boston, MA, USA

Patricia D’Amore

Jerry Niederkorn

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