Immunology and Allergy Clinics, An Issue of Immunology and Allergy Clinics of North America

1st Edition, Volume 40-3 - July 18, 2020
Editors: Mark Ballow, Elena Ronda Pérez
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 7 6 0 0 3 - 4
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 7 6 0 0 4 - 1

This issue of Immunology and Allergy Clinics, guest edited by Dr. Mark Ballow and Dr. Elena Perez, will provide up-to-date clinical concepts regarding Immunodeficiencies. Articles… Read more

Immunology and Allergy Clinics, An Issue of Immunology and Allergy Clinics of North America

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This issue of Immunology and Allergy Clinics, guest edited by Dr. Mark Ballow and Dr. Elena Perez, will provide up-to-date clinical concepts regarding Immunodeficiencies. Articles in this outstanding issue include: Precision Medicine for Patients with Primary Immune Dysregulation, Immune Disorders Associated with Abnormalities in Treg Cells, Defining Common Variable Immunodeficiency, The Importance of Primary Immune Deficiency Registries, Chronic Lung Disease in Primary Antibody Deficiency: Diagnosis and Management, Immune Deficiencies Associated with Th17 Immunity, Truths and Myths of Vaccines in Patients with Primary Immune Deficiency, The Nuts and Bolts of Subcutaneous Immunoglobulin Replacement Therapy, Newly Discovered Primary Immune Deficiencies, and Specific Antibody Deficiency.

Cover image
Title page
Table of Contents
Copyright
Contributors
Immunology and Allergy Clinics of North America
Preface
The Importance of Primary Immune Deficiency Registries: The United States Immunodeficiency Network Registry
Key points
Introduction
Insights from the registry
Answering questions
Summary
Defining Common Variable Immunodeficiency Disorders in 2020
Key points
Introduction
Separation of common variable immunodeficiency disorders and common variable immunodeficiency disorders-like disorders is based on genetics
Common variable immunodeficiency disorders diagnostic criteria
Studies that have compared these criteria
Application of these common variable immunodeficiency disorders diagnostic criteria to specific clinical scenarios
Summary
Vaccines in Patients with Primary Immune Deficiency
Key points
Introduction
Diagnosis of immune deficiency
Therapy of immune deficiency
Adverse effects of vaccines in patients with immune deficiency
Chronic Lung Disease in Primary Antibody Deficiency: Diagnosis and Management
Key points
Introduction
Asthma and chronic obstructive pulmonary disease
Bronchiectasis
Interstitial lung disease
Summary
IKAROS Family Zinc Finger 1–Associated Diseases in Primary Immunodeficiency Patients
Key points
Introduction
Haploinsufficiency allelic variants in Ikaros Family zinc finger 1
Dominant negative allelic variants in Ikaros Family zinc finger 1
Summary
Asplenia and Hyposplenism: An Underrecognized Immune Deficiency
Key points
Introduction
Causes Of Asplenia And Hyposplenism
Function and anatomy of the spleen
Assessing splenic function
Complications of splenic dysfunction
Prevention of infection
Splenic conservation
Discussion
Hemophagocytic Lymphohistiocytosis: Lessons Learned from the Dark Side
Key points
Introduction
Pathophysiology
Clinical presentation
“Genetic” hemophagocytic lymphohistiocytosis
Secondary hemophagocytic lymphohistiocytosis
Consideration of hemophagocytic lymphohistiocytosis in primary immune deficiency disorders and metabolic disorders
Diagnostic work-up
Treatment
Summary
Diagnosis and management of Specific Antibody Deficiency
Key points
Introduction
Diagnosis
Treatment of specific antibody deficiency
Summary
Precision Therapy for the Treatment of Primary Immunodysregulatory Diseases
Key points
Introduction
Cytotoxic T lymphocyte antigen-4 haploinsufficiency
Lipopolysaccharide-responsive beige-like anchor deficiency
Activated PI3K deficiency syndrome
Signal transduction and activator of transcription 1 and 3 – gain of function
STAT 1 – gain of function
STAT3 – gain of function
Inflammasome disorders
Summary
Nuts and Bolts of Subcutaneous Therapy
Key points
Introduction
Subcutaneous intravenous immunoglobulin versus intravenous immunoglobulin
Subcutaneous intravenous immunoglobulin dosing and infusion
Initiating subcutaneous intravenous immunoglobulin therapy
Summary

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Mark Ballow

Elena Ronda Pérez