Immunological Tolerance

Immunological Tolerance

Mechanisms and Potential Therapeutic Applications

1st Edition - January 1, 1974

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  • Editors: David H. Katz, Baruj Benacerraf
  • eBook ISBN: 9781483273433

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Immunological Tolerance: Mechanisms and Potential Therapeutic Applications documents the proceedings of a conference held at Brook Lodge, Michigan, April 27-May 1, 1974. The conference brought together many of the investigators who have actively contributed to furthering knowledge and understanding of immunological tolerance. It will be immediately clear to the reader that the conference was structured in a way to consider phenomena of tolerance and immune suppression as interrelated entities with a certain degree of emphasis on the possible common cellular mechanisms involved. The volume contains 36 contributions presented during the seven sessions of the conference. The papers presented in Session I examined T-cell tolerance. The presentations in Session II focused on B cell tolerance. The papers in Sessions III and IV focused on the mechanisms of B cell and T cell tolerance, respectively. Session V dealt with the activity of suppressor cells as a mechanism of tolerance. The papers in Session VI investigated the suppressive activity of antibody and antigen-antibody complexes. In Session VII a final General Discussion was held in order to identify what has been established concerning the phenomenology and mechanisms of specific immunological tolerance, what are the major unresolved issues, and what approaches appear most promising to answer these questions.

Table of Contents

  • Participants


    Photographs of Participants

    Session I: T Cell Tolerance

    Factors Influencing the Rate of Induction of Tolerance by Bovine Gamma Globulin

    Discussion following David Dresser

    Interactions of T and B Lymphocytes in Self-Tolerance and Autoimmunity

    Discussion following Anthony Allison

    The Cellular Basis for Establishing Tolerance or Immunity to Bovine γ-Globulin in Mice

    The Role of Accessory and Thymus-Derived Cells in Resistance to Tolerance Induction

    Suppressor Activity in Mice Tolerant of Hemocyanin

    Specific Suppression of the Immune Response by T Cells

    Tolerance to Contact Sensitivity—a Role for Suppressor T Cells?

    General Discussion—Session I

    Session II: B Cell Tolerance

    Activation of and Tolerance Induction in DNP-Specific B Cells: Analysis with Three Distinct DNP-Carrier Conjugates

    Discussion following William E. Paul

    Three Catergories of B Cell Tolerance Induced by Polysaccharides: Characteristics, Interrelationships and General Implications

    Discussion following James Howard

    Effect of Tolerance on Antibody-Binding Affinity

    Hapten-Specific Tolerance Induced by the DNP Derivative of D-Glutamic Acid and D-Lysine (D-GL) Copolymer

    Tolerance in Isolated B-Cell Populations Identified by an Allotype Marker: Role of T Cells in Induction

    B Cell Tolerance Induced by Non-Metabolized or Toxic Antigens

    Effect of Epitope Density on the Induction of Tolerance In Vitro

    General Discussion—Session II

    Session III: Mechanisms of B Cell Tolerance

    Reversible and Irreversible B Cell Tolerance: Distinguishing Properties and Mechanisms

    Discussion following David H. Katz

    High-Dose Tolerance in Mice Deficient in Reactive T Cells

    Discussion following Graham F. Mitchell

    Functional Relationships in Antigen-Receptor Interactions in B Lymphocytes

    B Cell Tolerance In Vitro—the Fate of the Tolerant Cell and Its Control by Hormones

    Graft-versus-Host Reactions, Tumor-Specific Immunity and Self-Tolerance

    Receptor Blockade by Tolerogen: One Explanation of Tolerance

    General Discussion—Session III

    Session IV: Mechanisms of T Cell Tolerance

    Unifying Concepts in Tolerance Induction for Various T and B Cell Sub-Populations

    Discussion following G.J.V. Nossal

    Cellular Parameters of the Tolerant State Induced to Human γ Globulin in

    Mice and of Its Modulation by Bacterial Lipopolysaccharides

    Discussion following Jacques M. Chiller

    Effect of Antigen Structure on the Induction of Tolerance in T Cells

    Indications of Active Suppression in Mouse Carriers of Lymphocytic Choriomeningitis Virus

    Interactions between T Cells Which Result in Suppression of T Cell Functions

    General Discussion—Session IV

    Session V: Activity of Suppressor Cells as a Mechanism of Tolerance


    Lack of Activity of Contra-Suppressor T Cells as a Mechanism of Tolerance

    Discussion following Richard K. Gershon

    The Mode and Sites of Action of Suppressor T Cells in the Antigen-Induced Differentiation of B Cells

    Discussion following Tomio Tada

    The Role of Suppressor T Cells in the Development of Low-Dose Paralysis to Type III Pneumococcal Polysaccharide

    Are Suppressor T Cells Responsible for Tolerance to a Soluble Antigen?

    Stimulation of Specific Suppressor T Cells by the Terpolymer L-Glutamic Acid60—L-Alanine30—L-Tyrosine10 in Genetic Non-Responder Mice

    Mechanism of Allotype Suppression in Mice

    Remarks on Allotype Suppression in Rabbits

    General Discussion—Session

    Session VI: Suppressive Activity of Antibody and Antigen-Antibody Complexes

    Is There a Unifying Concept for Diverse Models of Tolerance Induction?

    Discussion following Erwin Diener

    Blocking Factors in Tumor Immunity and Allograft Tolerance

    Discussion following Karl-Erik Hellstrom

    Antibody-Mediated Tolerance

    IgE Antibody-Specific Abrogation of an Established Immune Response in Mice by Modified Antigens

    General Discussion—Session

    Session VII: Summary and Potential Therapeutic Applications

    General Discussion—Session VII

    Closing Comments

Product details

  • No. of pages: 660
  • Language: English
  • Copyright: © Academic Press 1974
  • Published: January 1, 1974
  • Imprint: Academic Press
  • eBook ISBN: 9781483273433

About the Editors

David H. Katz

Baruj Benacerraf

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