Immunointervention in Autoimmune Diseases

Immunointervention in Autoimmune Diseases

Papers Based on an International Meeting in Paris, France, in June 1988

1st Edition - January 28, 1989

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  • Editor: J. F. Bach
  • eBook ISBN: 9781483282268

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Immunointervention in Autoimmune Diseases is a collection of papers presented at the 1988 International Meeting by the same title, held in Paris, France. This text contains 21 chapters and begins with surveys of the role of antigen in autoimmune responses and the moving boundaries between physiology and pathology of immunity. The succeeding chapters deal with the regulation, immunosuppressive therapy, infections, and immunointervention of autoimmune disorders. These topics are followed by discussions of specific immunosuppressive therapy for a particular disease, including type I diabetes, T-cell leukemia, and systemic lupus erythomatosus. This work also explores the principles of allograft, the use of monoclonal antibody, and OKT3. The remaining chapters consider the maintenance of autoimmunity and the risk/benefit in immunointervention for autoimmune diseases. This book will prove useful to immunologists, pathologists, physiologists, and researchers.

Table of Contents

  • Introduction

    The Role of Antigen in Autoimmune Responses with Special References to Changes in Carbohydrate Structure of IgG in Rheumatoid Arthritis

    Autoimmunity: The Moving Boundaries Between Physiology and Pathology

    Cyclosporine A and the Regulation of Autoimmune Disease

    Hazards of Cyclosporine A Therapy and Recommendations for its Use

    Cancer is a Long-Term Hazard of Immunosuppressive Therapy

    Some Viral Infections and Related Disorders Associated with Long-Term Immunosuppressive Treatments

    Approach to the Use of Antigen Non-Specific Immunosuppression in Systemic Lupus Erythematosus and Other Rheumatic Autoimmune Diseases

    Immunointervention in Skin Disorders

    Therapeutic Immunosuppression in Type I (Insulin-Dependent) Diabetes

    The Clinical Use of Immunosuppressants in the Treatment of Putative Autoimmune Intra-Ocular Diseases

    A Theoretical Framework for Self-Tolerance and its Relevance to Therapy of Autoimmune Disease

    Clinical Use of OKT3: The Role of Cytokine Release and Xenosensitization

    The Multichain Interleukin-2-Receptor: A Target for Immunotherapy of Patients with Adult T-cell Leukemia, Autoimmune Disorders and Individuals Receiving Allografts

    Anti-IL-2-R Monoclonal Antibody in Allograft Recipients

    Therapy of Autoimmune Diseases with Monoclonal Antibodies to Class II Major Histocompatibility Complex Antigens: The Role of T Lymphocytes

    Idiotype Selection is an Immunoregulatory Mechanism which Contributes to the Pathogenesis of Systemic Lupus Erythematosus

    Induction of SLE-Like Disease in Naive Mice with a Monoclonal Anti-DNA Antibody Derived from a Patient with Polymyositis Carrying the 16/6 ID

    Cellular Mechanisms in Immune Tolerance and Treatment of Autoimmune Disease: Studies Using Total Lymphoid Irradiation (TLI)

    Maintenance of Autoimmunity

    The Risk/Benefit Ratio in Immunointervention for Autoimmune Diseases

Product details

  • No. of pages: 230
  • Language: English
  • Copyright: © Academic Press 1989
  • Published: January 28, 1989
  • Imprint: Academic Press
  • eBook ISBN: 9781483282268

About the Editor

J. F. Bach

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